KEGG   ENZYME: 1.1.1.300Help
Entry
EC 1.1.1.300                Enzyme                                 

Name
NADP-retinol dehydrogenase;
all-trans retinal reductase (ambiguous);
all-trans-retinol dehydrogenase;
NADP(H)-dependent retinol dehydrogenase/reductase;
RDH11;
RDH12;
RDH13;
RDH14;
retinol dehydrogenase 12;
retinol dehydrogenase 14;
retinol dehydrogenase [NADP+];
RalR1;
PSDR1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
retinol:NADP+ oxidoreductase
Reaction(IUBMB)
retinol + NADP+ = retinal + NADPH + H+ [RN:R08379]
Reaction(KEGG)
Substrate
retinol [CPD:C00473];
NADP+ [CPD:C00006]
Product
retinal [CPD:C00376];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.
History
EC 1.1.1.300 created 2009
Orthology
K11146  short-chain dehydrogenase/reductase 3
K11152  retinol dehydrogenase 11
K11153  retinol dehydrogenase 12
K11161  retinol dehydrogenase 13
Genes
HSA: 112724(RDH13) 145226(RDH12) 51109(RDH11) 9249(DHRS3)
PTR: 100615509(RDH12) 452986(RDH11) 456293(RDH13) 737006(DHRS3)
PPS: 100971367(DHRS3) 100975938(RDH11) 100976717(RDH12) 100995016(RDH13)
GGO: 101133959(RDH12) 101134301(RDH11) 101136764(DHRS3)
PON: 100173396(RDH11) 100443109(RDH13) 100444779(RDH12) 100446028(DHRS3)
NLE: 100590397(RDH11) 100592081(RDH12) 100595824(RDH13) 100599507(DHRS3) 115833951
MCC: 711195(RDH11) 711438(RDH12) 715548(DHRS3) 722798
MCF: 101865597(RDH12) 101866088(RDH11) 102118061(RDH13) 102142015(DHRS3)
CSAB: 103225584(DHRS3) 103229214(RDH11) 103229215(RDH12) 103235287(RDH13)
RRO: 104664937(RDH12) 104664944(RDH11) 104668927(DHRS3) 104674753(RDH13)
RBB: 108533721(RDH11) 108533722(RDH12) 108539385(DHRS3) 108542524(RDH13) 108542526
CJC: 100386416(DHRS3) 100403102(RDH12) 100406713(RDH13) 103787305(RDH11)
SBQ: 101033448(RDH12) 101039627(DHRS3) 101045253(RDH13) 104649866(RDH11)
MMU: 108841(Rdh13) 17252(Rdh11) 20148(Dhrs3) 77974(Rdh12)
MCAL: 110292172(Dhrs3) 110297351(Rdh13) 110307013(Rdh11) 110307230(Rdh12)
MPAH: 110323041(Dhrs3) 110324273(Rdh11) 110324761(Rdh12) 110336860(Rdh13)
RNO: 313689(Dhrs3) 314264(Rdh12) 361504(Rdh13) 362757(Rdh11)
MUN: 110539426(Dhrs3) 110540988(Rdh13) 110557055(Rdh11) 110563447 110563448
CGE: 100756186(Dhrs3) 100759393(Rdh13) 100759583(Rdh12) 100759877(Rdh11)
NGI: 103744827(Rdh13) 103747479(Dhrs3) 103749297(Rdh11) 103749298(Rdh12)
HGL: 101707915(Dhrs3) 101715642(Rdh12) 101716026(Rdh13) 101716314(Rdh11)
CCAN: 109683963(Dhrs3) 109694521(Rdh11) 109694522(Rdh12) 109696274(Rdh13)
OCU: 100337836(RDH12) 100344639(RDH13) 100348969 100353716(RDH11) 103352513(DHRS3)
TUP: 102494216(RDH13) 102498009(RDH11) 102498963(RDH12) 102502620(DHRS3) 106735058
CFA: 480366(RDH11) 487436(DHRS3) 490744(RDH12) 611373(RDH13)
VVP: 112909346(RDH13) 112927128(RDH12) 112927195(RDH11) 112929696(DHRS3)
AML: 100468936(RDH12) 100469186(RDH11) 100470711(RDH13) 100481198(DHRS3)
UMR: 103666638(DHRS3) 103671847(RDH12) 103671858(RDH11) 103680271(RDH13)
ORO: 101365883(RDH11) 101366366(RDH12) 101370738(DHRS3) 101383491(RDH13)
FCA: 101080307(DHRS3) 101093062(RDH13) 101093193(RDH11) 101093615(RDH12)
PTG: 102958225(RDH12) 102958792(RDH11) 102961855(RDH13) 102970609(DHRS3)
PPAD: 109259903(RDH13) 109268278(RDH12) 109268280(RDH11) 109274137(DHRS3)
AJU: 106971557(RDH11) 106971559(RDH12) 106980937(RDH13) 106988168(DHRS3)
BTA: 281482(DHRS3) 369021(RDH12) 505995(RDH11) 508082(RDH13)
BOM: 102265772(DHRS3) 102270792(RDH13) 102270801(RDH11) 102271090(RDH12)
BIU: 109564569(RDH12) 109565274(RDH11) 109570447(DHRS3) 109572930(RDH13)
BBUB: 102404826(DHRS3) 102405382(RDH12) 102405721(RDH11) 102411635(RDH13)
CHX: 102171883(RDH11) 102173010(RDH12) 102179583(DHRS3) 102181531(RDH13)
OAS: 101109288(DHRS3) 101115127(RDH11) 101115797(RDH12) 101122882 114108681(RDH13)
SSC: 100153020(RDH12) 100154684(RDH11) 100514967(DHRS3) 110261049(RDH13)
CFR: 102511414(RDH13) 102516964(RDH12) 102517215(RDH11) 102524578(DHRS3)
CDK: 105086164(RDH12) 105086165(RDH11) 105098733(RDH13) 105107044(DHRS3)
BACU: 103008561(RDH11) 103009435(RDH12) 103011644(RDH13) 103018059(DHRS3)
LVE: 103082238(DHRS3) 103085939(RDH13) 103090972(RDH12) 103091250(RDH11)
OOR: 101277554(RDH13) 101283025(RDH11) 101283442(RDH12) 101290385(DHRS3)
DLE: 111173039(RDH11) 111173259(RDH12) 111181006(RDH13) 111187101(DHRS3)
PCAD: 102978048(RDH12) 102978320(RDH11) 102982136(DHRS3) 102987556 114484116
ECB: 100055280(RDH13) 100055537(DHRS3) 100063295(RDH11) 100063369(RDH12)
EPZ: 103541138(RDH11) 103541139(RDH12) 103552172(DHRS3) 103554723(RDH13)
EAI: 106836659(DHRS3) 106840917(RDH13) 106844772(RDH12) 106844775
MYB: 102246028(RDH13) 102248154(DHRS3) 102260151(RDH11) 102260844(RDH12)
MYD: 102756510(RDH13) 102762827(DHRS3) 102764631(RDH12) 102765110(RDH11)
MNA: 107531562(DHRS3) 107541313(RDH13) 107545709(RDH11) 107545710(RDH12)
HAI: 109373731(RDH13) 109381266(DHRS3) 109382035(RDH11) 109382038(RDH12)
DRO: 112299121(DHRS3) 112311390(RDH12) 112311797(RDH11) 112314049(RDH13)
PALE: 102880345(DHRS3) 102886009(RDH11) 102886424(RDH12) 102890503(RDH13)
RAY: 107503265(RDH11) 107503281(RDH12) 107513138(DHRS3) 107515444(RDH13)
MJV: 108396332(RDH13) 108402930(DHRS3) 108410077(RDH11) 108410078(RDH12)
LAV: 100656973(DHRS3) 100659620(RDH12) 100664643(RDH11) 100668990(RDH13)
MDO: 100010099(DHRS3) 100028370(RDH11) 100028379(RDH12)
SHR: 100913855(DHRS3) 100923639(RDH11) 100923904 100931844(RDH13)
PCW: 110198918(DHRS3) 110220123(RDH13) 110220578(RDH12) 110220629(RDH11)
GGA: 419480(DHRS3) 423274(RDH12)
MGP: 100540846 100541886(DHRS3)
CJO: 107314931(RDH12) 107323359(DHRS3)
NMEL: 110401302 110408680(DHRS3)
APLA: 101792259(DHRS3) 101793409
ACYG: 106031772 106040190(DHRS3)
TGU: 100221618(DHRS3) 100226769
LSR: 110473996 110476789(DHRS3)
SCAN: 103820840(DHRS3) 103826955
GFR: 102032402(DHRS3) 102032925(RDH12)
FAB: 101814379(DHRS3) 101816060(RDH12)
PHI: 102106104(RDH12) 102110985(DHRS3)
PMAJ: 107205238 107213682(DHRS3)
CCAE: 111930091 111938724(DHRS3)
CCW: 104688342 104693251(DHRS3)
ETL: 114062535 114065123(DHRS3)
FPG: 101916630(RDH12) 101921484(DHRS3)
FCH: 102055890 102058887(DHRS3)
EGZ: 104122065 104133092(DHRS3)
NNI: 104009010(DHRS3) 104020414
ACUN: 113480412 113487888(DHRS3)
PADL: 103914367 103917993(DHRS3)
AAM: 106482457(DHRS3) 106483104(RDH12)
ASN: 102370531(DHRS3) 102373718
AMJ: 102567292(RDH12) 102574201(DHRS3)
PSS: 102445977(DHRS3) 102446647
CMY: 102934533(RDH12) 102944040(DHRS3)
CPIC: 101941293(DHRS3) 101950060(RDH12)
PMUR: 107284674(DHRS3) 107285841
GJA: 107112214(RDH12) 107124081(DHRS3)
XLA: 108697667 444106(rdh13.L) 444269(dhrs3.L)
XTR: 493258(dhrs3) 496409(rdh13)
NPR: 108783931(DHRS3) 108788946(RDH13) 108793980
DRE: 436597(rdh12) 450050(dhrs3b)
MALB: 109962304 109963510(rdh13) 109963732 109972345(dhrs3) 109973374(rdh12)
LCM: 102347732(RDH13) 102349654 102353614(RDH12) 102354914 102361459(DHRS3)
DPE: 6600030
DMN: 108162143
DAZ: 108619501
DNV: 115564143
DHE: 111602060
LCQ: 111679271
AALB: 109423352
BIM: 100745829
BTER: 100650146
CCAL: 108629140
DQU: 106748801
PRAP: 110999155
HAW: 110371776
CSCU: 111627401
EGL: EGR_02372
AMIL: 114969073
CPAP: 110820086
CIT: 102619498
CAM: 101509179
LJA: Lj1g3v0342000.1(Lj1g3v0342000.1) Lj2g3v1016620.1(Lj2g3v1016620.1) Lj4g3v3014530.1(Lj4g3v3014530.1) Lj5g3v0614340.2(Lj5g3v0614340.2)
FVE: 101295243
RCN: 112193888
CMO: 103486400
JCU: 105636270
HBR: 110664761
OEU: 111407652
BVG: 104892580
SOE: 110796518
DOSA: Os09t0570300-01(Os09g0570300) Os10t0547900-01(Os10g0547900)
ATS: 109772785(LOC109772785)
APRO: F751_1025
DFA: DFA_01654
SALN: SALB1_1281
FLM: MY04_4115
 » show all
Taxonomy
Reference
1  [PMID:15865448]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY
  Title
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.
  Journal
Biochemistry 44:7035-47 (2005)
DOI:10.1021/bi050226k
  Sequence
[hsa:145226]
Reference
2  [PMID:18039331]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY
  Title
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.
  Journal
FEBS J 275:138-47 (2008)
DOI:10.1111/j.1742-4658.2007.06184.x
  Sequence
[hsa:112724]
Reference
3  [PMID:9705317]
  Authors
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K
  Title
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.
  Journal
J Biol Chem 273:21790-9 (1998)
DOI:10.1074/jbc.273.34.21790
  Sequence
[hsa:9249] [mmu:20148] [bta:281482]
Reference
4  [PMID:12036956]
  Authors
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS
  Title
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).
  Journal
J Biol Chem 277:28909-15 (2002)
DOI:10.1074/jbc.M202588200
  Sequence
[hsa:51109]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.300
IUBMB Enzyme Nomenclature: 1.1.1.300
ExPASy - ENZYME nomenclature database: 1.1.1.300
BRENDA, the Enzyme Database: 1.1.1.300

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