KEGG   ENZYME: 1.1.1.300Help
Entry
EC 1.1.1.300                Enzyme                                 

Name
NADP-retinol dehydrogenase;
all-trans retinal reductase (ambiguous);
all-trans-retinol dehydrogenase;
NADP(H)-dependent retinol dehydrogenase/reductase;
RDH11;
RDH12;
RDH13;
RDH14;
retinol dehydrogenase 12;
retinol dehydrogenase 14;
retinol dehydrogenase [NADP+];
RalR1;
PSDR1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
retinol:NADP+ oxidoreductase
Reaction(IUBMB)
retinol + NADP+ = retinal + NADPH + H+ [RN:R08379]
Reaction(KEGG)
Substrate
retinol [CPD:C00473];
NADP+ [CPD:C00006]
Product
retinal [CPD:C00376];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.
History
EC 1.1.1.300 created 2009
Orthology
K11146  short-chain dehydrogenase/reductase 3
K11152  retinol dehydrogenase 11
K11153  retinol dehydrogenase 12
K11161  retinol dehydrogenase 13
Genes
HSA: 112724(RDH13) 145226(RDH12) 51109(RDH11) 9249(DHRS3)
PTR: 100615509(RDH12) 452986(RDH11) 456293(RDH13) 737006(DHRS3)
PPS: 100971367(DHRS3) 100975938(RDH11) 100976717(RDH12) 100995016(RDH13)
GGO: 101132424(RDH13) 101133959(RDH12) 101134301(RDH11) 101136764(DHRS3)
PON: 100173396(RDH11) 100443109(RDH13) 100444779(RDH12) 100446028(DHRS3)
NLE: 100590397(RDH11) 100592081(RDH12) 100595824(RDH13) 100599507(DHRS3)
MCC: 711195(RDH11) 711438(RDH12) 715548(DHRS3) 722798(RDH13)
MCF: 101865597(RDH12) 101866088(RDH11) 102118061(RDH13) 102142015(DHRS3)
CSAB: 103225584(DHRS3) 103229214(RDH11) 103229215(RDH12) 103235287(RDH13)
RRO: 104664937(RDH12) 104664944(RDH11) 104668927(DHRS3) 104674753(RDH13)
RBB: 108533721(RDH11) 108533722(RDH12) 108539385(DHRS3) 108542524(RDH13) 108542526
CJC: 100386416(DHRS3) 100403102(RDH12) 100406713(RDH13) 103787305(RDH11)
SBQ: 101033448(RDH12) 101039627(DHRS3) 101045253(RDH13) 104649866(RDH11)
MMU: 108841(Rdh13) 17252(Rdh11) 20148(Dhrs3) 77974(Rdh12)
RNO: 313689(Dhrs3) 314264(Rdh12) 361504(Rdh13) 362757(Rdh11)
CGE: 100756186(Dhrs3) 100759393(Rdh13) 100759583(Rdh12) 100759877(Rdh11)
NGI: 103744827(Rdh13) 103747479(Dhrs3) 103749297(Rdh11) 103749298(Rdh12)
HGL: 101707915(Dhrs3) 101715642(Rdh12) 101716026(Rdh13) 101716314(Rdh11)
CCAN: 109683963(Dhrs3) 109694521(Rdh11) 109694522(Rdh12) 109696274(Rdh13)
OCU: 100337836(RDH12) 100344639(RDH13) 100348969 100353716(RDH11) 103352513(DHRS3)
TUP: 102494216(RDH13) 102498009(RDH11) 102498963(RDH12) 102502620(DHRS3) 106735058
CFA: 480366(RDH11) 487436(DHRS3) 490744(RDH12) 611373(RDH13)
AML: 100468936(RDH12) 100469186(RDH11) 100470711(RDH13) 100481198(DHRS3)
UMR: 103666638(DHRS3) 103671847(RDH12) 103671858(RDH11) 103680271(RDH13)
ORO: 101365883(RDH11) 101366366(RDH12) 101370738(DHRS3) 101383491(RDH13)
FCA: 101080307(DHRS3) 101093062(RDH13) 101093193(RDH11) 101093615(RDH12)
PTG: 102958225(RDH12) 102958792(RDH11) 102961855(RDH13) 102970609(DHRS3)
AJU: 106971557(RDH11) 106971559(RDH12) 106980937(RDH13) 106988168(DHRS3)
BTA: 281482(DHRS3) 369021(RDH12) 505995(RDH11) 508082(RDH13)
BOM: 102265772(DHRS3) 102270792(RDH13) 102270801(RDH11) 102271090(RDH12)
BIU: 109564569(RDH12) 109565274(RDH11) 109570447(DHRS3) 109572930(RDH13)
PHD: 102321429(RDH12) 102322389(RDH11) 102323197(DHRS3) 102329922(RDH13)
CHX: 102171883(RDH11) 102173010(RDH12) 102179583(DHRS3) 102181531(RDH13)
OAS: 101109288(DHRS3) 101115127(RDH11) 101115797(RDH12) 101122882(RDH13)
SSC: 100153020(RDH12) 100154684(RDH11) 100514967(DHRS3) 110261049(RDH13)
CFR: 102511414(RDH13) 102516964(RDH12) 102517215(RDH11) 102524578(DHRS3)
CDK: 105086164(RDH12) 105086165(RDH11) 105098733(RDH13) 105107044(DHRS3)
BACU: 103008561(RDH11) 103009435(RDH12) 103011644(RDH13) 103018059(DHRS3)
LVE: 103082238(DHRS3) 103085939(RDH13) 103090972(RDH12) 103091250(RDH11)
OOR: 101277554(RDH13) 101283025(RDH11) 101283442(RDH12) 101290385(DHRS3)
ECB: 100055280(RDH13) 100055537(DHRS3) 100063295(RDH11) 100063369(RDH12)
EPZ: 103541138(RDH11) 103541139(RDH12) 103552172(DHRS3) 103554723(RDH13)
EAI: 106836659(DHRS3) 106840917(RDH13) 106844772(RDH12) 106844775
MYB: 102246028(RDH13) 102248154(DHRS3) 102260151(RDH11) 102260844(RDH12)
MYD: 102756510(RDH13) 102762827(DHRS3) 102764631(RDH12) 102765110(RDH11)
HAI: 109373731(RDH13) 109381266(DHRS3) 109382035(RDH11) 109382038(RDH12)
RSS: 109434208(RDH13) 109448201(RDH12) 109448378(RDH11) 109460692(DHRS3)
PALE: 102880345(DHRS3) 102886009(RDH11) 102886424(RDH12) 102890503(RDH13)
LAV: 100656973(DHRS3) 100659620(RDH12) 100664643(RDH11) 100668990(RDH13)
MDO: 100010099(DHRS3) 100028370(RDH11) 100028379(RDH12)
SHR: 100913855(DHRS3) 100923639(RDH11) 100923904 100931844(RDH13)
GGA: 419480(DHRS3) 423274(RDH12)
MGP: 100540846 100541886(DHRS3)
CJO: 107314931(RDH12) 107323359(DHRS3)
APLA: 101792259(DHRS3) 101793409
ACYG: 106031772 106040190(DHRS3)
TGU: 100221618(DHRS3) 100226769(RDH12)
GFR: 102032402(DHRS3) 102032925(RDH12)
FAB: 101814379(DHRS3) 101816060(RDH12)
PHI: 102106104(RDH12) 102110985(DHRS3)
PMAJ: 107205238 107213682(DHRS3)
CCAE: 111930091 111938724(DHRS3)
CCW: 104688342 104693251(DHRS3)
FPG: 101916630(RDH12) 101921484(DHRS3)
FCH: 102055890(RDH12) 102058887(DHRS3)
EGZ: 104122065 104133092(DHRS3)
AAM: 106482457(DHRS3) 106483104(RDH12)
ASN: 102370531(DHRS3) 102373718
AMJ: 102567292(RDH12) 102574201(DHRS3)
PSS: 102445977(DHRS3) 102446647
CMY: 102934533(RDH12) 102944040(DHRS3)
CPIC: 101941293(DHRS3) 101950060(RDH12)
GJA: 107112214(RDH12) 107124081(DHRS3)
XLA: 108697667 444106(rdh13.L) 444269(dhrs3.L)
XTR: 493258(dhrs3) 496409(rdh13)
NPR: 108783931(DHRS3) 108788946(RDH13) 108793980
DRE: 436597(rdh12) 450050(dhrs3b)
LCM: 102347732(RDH13) 102349654 102353614(RDH12) 102354914 102361459(DHRS3)
DPE: 6600030
BIM: 100745829
BTER: 100650146
DQU: 106748801
PMAC: 106719654
PRAP: 110999155
HAW: 110371776
TSP: Tsp_04022
EGL: EGR_02372
TCC: 18597799
CAM: 101509179
LJA: Lj1g3v0342000.1(Lj1g3v0342000.1) Lj2g3v1016620.1(Lj2g3v1016620.1) Lj4g3v3014530.1(Lj4g3v3014530.1) Lj5g3v0614340.2(Lj5g3v0614340.2)
FVE: 101295243
PPER: 18772531
JCU: 105636270
HBR: 110664761
JRE: 109006782
OEU: 111405301
BVG: 104892580
DOSA: Os10t0547900-01(Os10g0547900)
ATS: 109754769(LOC109754769) 109772785(LOC109772785)
ZMA: 100285880
DCT: 110110576
APRO: F751_1025
DFA: DFA_01654
SALN: SALB1_1281
HSW: Hsw_2466
FLM: MY04_4115
 » show all
Taxonomy
Reference
1  [PMID:15865448]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY
  Title
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.
  Journal
Biochemistry 44:7035-47 (2005)
DOI:10.1021/bi050226k
  Sequence
[hsa:145226]
Reference
2  [PMID:18039331]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY
  Title
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.
  Journal
FEBS J 275:138-47 (2008)
DOI:10.1111/j.1742-4658.2007.06184.x
  Sequence
[hsa:112724]
Reference
3  [PMID:9705317]
  Authors
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K
  Title
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.
  Journal
J Biol Chem 273:21790-9 (1998)
DOI:10.1074/jbc.273.34.21790
  Sequence
[hsa:9249] [mmu:20148] [bta:281482]
Reference
4  [PMID:12036956]
  Authors
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS
  Title
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).
  Journal
J Biol Chem 277:28909-15 (2002)
DOI:10.1074/jbc.M202588200
  Sequence
[hsa:51109]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.300
IUBMB Enzyme Nomenclature: 1.1.1.300
ExPASy - ENZYME nomenclature database: 1.1.1.300
BRENDA, the Enzyme Database: 1.1.1.300

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