KEGG   ENZYME: 1.1.1.300Help
Entry
EC 1.1.1.300                Enzyme                                 

Name
NADP-retinol dehydrogenase;
all-trans retinal reductase (ambiguous);
all-trans-retinol dehydrogenase;
NADP(H)-dependent retinol dehydrogenase/reductase;
RDH11;
RDH12;
RDH13;
RDH14;
retinol dehydrogenase 12;
retinol dehydrogenase 14;
retinol dehydrogenase [NADP+];
RalR1;
PSDR1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
retinol:NADP+ oxidoreductase
Reaction(IUBMB)
retinol + NADP+ = retinal + NADPH + H+ [RN:R08379]
Reaction(KEGG)
Substrate
retinol [CPD:C00473];
NADP+ [CPD:C00006]
Product
retinal [CPD:C00376];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.
History
EC 1.1.1.300 created 2009
Orthology
K11146  short-chain dehydrogenase/reductase 3
K11152  retinol dehydrogenase 11
K11153  retinol dehydrogenase 12
K11161  retinol dehydrogenase 13
Genes
HSA: 112724(RDH13) 145226(RDH12) 51109(RDH11) 9249(DHRS3)
PTR: 100615509(RDH12) 452986(RDH11) 456293(RDH13) 737006(DHRS3)
PPS: 100971367(DHRS3) 100975938(RDH11) 100976717(RDH12) 100995016(RDH13)
GGO: 101132424(RDH13) 101133959(RDH12) 101134301(RDH11) 101136764(DHRS3)
PON: 100173396(RDH11) 100443109(RDH13) 100444779(RDH12) 100446028(DHRS3)
NLE: 100590397(RDH11) 100592081(RDH12) 100595824(RDH13) 100599507(DHRS3)
MCC: 711195(RDH11) 711438(RDH12) 715548(DHRS3) 722798(RDH13)
MCF: 101865597(RDH12) 101866088(RDH11) 102118061(RDH13) 102142015(DHRS3)
CSAB: 103225584(DHRS3) 103229214(RDH11) 103229215(RDH12) 103235287(RDH13)
RRO: 104664937(RDH12) 104664944(RDH11) 104668927(DHRS3) 104674753(RDH13)
RBB: 108533721(RDH11) 108533722(RDH12) 108539385(DHRS3) 108542524(RDH13) 108542526
CJC: 100386416(DHRS3) 100403102(RDH12) 100406713(RDH13) 103787305(RDH11)
SBQ: 101033448(RDH12) 101039627(DHRS3) 101045253(RDH13) 104649866(RDH11)
MMU: 108841(Rdh13) 17252(Rdh11) 20148(Dhrs3) 77974(Rdh12)
RNO: 313689(Dhrs3) 314264(Rdh12) 361504(Rdh13) 362757(Rdh11)
CGE: 100756186(Dhrs3) 100759393(Rdh13) 100759583(Rdh12) 100759877(Rdh11)
NGI: 103744827(Rdh13) 103747479(Dhrs3) 103749297(Rdh11) 103749298(Rdh12)
HGL: 101707915(Dhrs3) 101715642(Rdh12) 101716026(Rdh13) 101716314(Rdh11)
CCAN: 109683963(Dhrs3) 109694521(Rdh11) 109694522(Rdh12) 109696274(Rdh13)
OCU: 100337836(RDH12) 100344639(RDH13) 100348969 100353716(RDH11) 103352513(DHRS3)
TUP: 102494216(RDH13) 102498009(RDH11) 102498963(RDH12) 102502620(DHRS3) 106735058
CFA: 480366(RDH11) 487436(DHRS3) 490744(RDH12) 611373(RDH13)
AML: 100468936(RDH12) 100469186(RDH11) 100470711(RDH13) 100481198(DHRS3)
UMR: 103666638(DHRS3) 103671847(RDH12) 103671858(RDH11) 103680271(RDH13)
ORO: 101365883(RDH11) 101366366(RDH12) 101370738(DHRS3) 101383491(RDH13)
FCA: 101080307(DHRS3) 101093062(RDH13) 101093193(RDH11) 101093615(RDH12)
PTG: 102958225(RDH12) 102958792(RDH11) 102961855(RDH13) 102970609(DHRS3)
AJU: 106971557(RDH11) 106971559(RDH12) 106980937(RDH13) 106988168(DHRS3)
BTA: 281482(DHRS3) 369021(RDH12) 505995(RDH11) 508082(RDH13)
BOM: 102265772(DHRS3) 102270792(RDH13) 102270801(RDH11) 102271090(RDH12)
BIU: 109564569(RDH12) 109565274(RDH11) 109570447(DHRS3) 109572930(RDH13)
PHD: 102321429(RDH12) 102322389(RDH11) 102323197(DHRS3) 102329922(RDH13)
CHX: 102171883(RDH11) 102173010(RDH12) 102179583(DHRS3) 102181531(RDH13)
OAS: 101109288(DHRS3) 101115127(RDH11) 101115797(RDH12) 101122882(RDH13)
SSC: 100153020(RDH12) 100154684(RDH11) 100514967(DHRS3) 110261049(RDH13)
CFR: 102511414(RDH13) 102516964(RDH12) 102517215(RDH11) 102524578(DHRS3)
CDK: 105086164(RDH12) 105086165(RDH11) 105098733(RDH13) 105107044(DHRS3)
BACU: 103008561(RDH11) 103009435(RDH12) 103011644(RDH13) 103018059(DHRS3)
LVE: 103082238(DHRS3) 103085939(RDH13) 103090972(RDH12) 103091250(RDH11)
OOR: 101277554(RDH13) 101283025(RDH11) 101283442(RDH12) 101290385(DHRS3)
ECB: 100055280(RDH13) 100055537(DHRS3) 100063295(RDH11) 100063369(RDH12)
EPZ: 103541138(RDH11) 103541139(RDH12) 103552172(DHRS3) 103554723(RDH13)
EAI: 106836659(DHRS3) 106840917(RDH13) 106844772(RDH12) 106844775
MYB: 102246028(RDH13) 102248154(DHRS3) 102260151(RDH11) 102260844(RDH12)
MYD: 102756510(RDH13) 102762827(DHRS3) 102764631(RDH12) 102765110(RDH11)
HAI: 109373731(RDH13) 109381266(DHRS3) 109382035(RDH11) 109382038(RDH12)
RSS: 109434208(RDH13) 109448201(RDH12) 109448378(RDH11) 109460692(DHRS3)
PALE: 102880345(DHRS3) 102886009(RDH11) 102886424(RDH12) 102890503(RDH13)
LAV: 100656973(DHRS3) 100659620(RDH12) 100664643(RDH11) 100668990(RDH13)
TMU: 101355027 101357938 101358377 101360145
MDO: 100010099(DHRS3) 100028370(RDH11) 100028379(RDH12)
SHR: 100913855(DHRS3) 100923639(RDH11) 100923904 100931844(RDH13)
OAA: 100078920(RDH13) 100090663(DHRS3) 100092853 100092857
GGA: 419480(DHRS3) 423274(RDH12)
MGP: 100540846 100541886(DHRS3)
CJO: 107314931(RDH12) 107323359(DHRS3)
APLA: 101792259(DHRS3) 101793409(RDH12)
ACYG: 106031772 106040190(DHRS3)
TGU: 100221618(DHRS3) 100226769(RDH12)
GFR: 102032402(DHRS3) 102032925(RDH12)
FAB: 101814379(DHRS3) 101816060(RDH12)
PHI: 102106104(RDH12) 102110985(DHRS3)
PMAJ: 107205238 107213682(DHRS3)
CCAE: 111930091 111938724(DHRS3)
CCW: 104688342 104693251(DHRS3)
FPG: 101916630(RDH12) 101921484(DHRS3)
FCH: 102055890(RDH12) 102058887(DHRS3)
CLV: 102087489(DHRS3) 102088180 102088364
EGZ: 104122065 104133092(DHRS3)
AAM: 106482457(DHRS3) 106483104(RDH12)
ASN: 102370531(DHRS3) 102373718
AMJ: 102567292(RDH12) 102574201(DHRS3)
PSS: 102445977(DHRS3) 102446647
CMY: 102934533(RDH12) 102944040(DHRS3)
CPIC: 101941293(DHRS3) 101950060(RDH12)
ACS: 100556987 100557137(dhrs3) 100557184 100557378 100557577
PVT: 110082355 110082458(DHRS3) 110082559
PBI: 103052660 103054360(DHRS3) 103055029 103056373
GJA: 107112214(RDH12) 107124081(DHRS3)
XLA: 108697667 444106(rdh13.L) 444269(dhrs3.L)
XTR: 493258(dhrs3) 496409(rdh13)
NPR: 108783931(DHRS3) 108788946(RDH13)
DRE: 436597(rdh12) 450050(dhrs3b)
SRX: 107705384 107706178 107712670 107712786 107724212 107727205 107727210 107727813 107732076 107732574 107736172 107737702 107746919 107749419 107756193 107758290
SANH: 107655021 107657757 107675518 107677205 107685629 107686084 107686693 107686694 107687474 107691330 107695397 107697223 107703071
SGH: 107555693 107556114 107566779 107568630(dhrs3) 107585486 107586344 107588523 107588583 107591109 107591613 107593436 107595137 107595155 107599658 107599744
CCAR: 109044936 109050290 109050291 109055081 109072076 109072700 109077249 109077257 109093510 109099714
IPU: 100528113(rdh13) 108255144(dhrs3) 108255501 108257080 108263330(rdh11) 108268141 108270740(RDH12) 108275517(DHRS3) 108280225
AMEX: 103027802 103033641 103035184 103038275 103038897 103041043 103042050(dhrs3) 103043116 103044420 103044922 111193417
TRU: 101064046(dhrs3) 101069118(rdh13) 101071170(rdh12) 101073746 101073971 101078532 101079748
TNG: GSTEN00005665G001 GSTEN00015467G001 GSTEN00022954G001 GSTEN00024054G001 GSTEN00025514G001 GSTEN00034558G001
LCO: 104917935(dhrs3) 104919686(rdh13) 104922588 104922589 104935572(rdh12) 104937074 104937271 109142445
NCC: 104940843 104942382 104946353(rdh13) 104955652(dhrs3) 104955729 104957158 104957588 104957590 104964031
MZE: 101467449 101467758 101470050(rdh13) 101473687 101474963 101480615(rdh12) 101486960(dhrs3) 112435597
OLA: 101159580(dhrs3) 101164264 101164512(rdh13) 101164605 101167436 101168330 111946613
XMA: 102218522 102221571(rdh13) 102224795 102225111 102227890(rdh12) 102229237 102234622 102237356(dhrs3)
PRET: 103456531 103456533 103456786 103458238 103464767(dhrs3) 103466624 103477479 103481086(rdh13)
NFU: 107379016 107383151 107383153 107384894(dhrs3) 107388056(rdh13) 107391941
KMR: 108228975 108230029 108230278 108231475(dhrs3) 108232585 108237226(rdh13) 108243166 108243167
CSEM: 103376897 103376898 103377359 103381277(rdh12) 103381690(rdh13) 103386641(dhrs3)
LCF: 108876948 108884722 108885195(dhrs3) 108886670(rdh12) 108886781(rdh13) 108900014 108900796 108900797
SDU: 111218329 111219785(rdh13) 111224335 111233594(dhrs3) 111234073 111237149 111237232 111237248
HCQ: 109513475 109513950 109515570 109515571 109517403(rdh12) 109521619(dhrs3) 109524726 109526512(rdh13)
BPEC: 110157358 110157895 110159576(rdh13) 110160976 110161020 110165520 110174741(dhrs3) 110175465
MALB: 109962304 109963510(rdh13) 109963732 109972345(dhrs3) 109973374(rdh12)
SASA: 100196075(rdh12) 100380445(dhrs3) 106561176 106566814 106569221 106570158 106572239 106578408 106578413 106579211(rdh13) 106579697 106582983 106584900 106588337 106593045 106598856(RDH12) 106606092 106611488
OTW: 112215488 112215489 112215877 112218506 112218596 112222076 112223708(rdh13) 112227853 112229755 112232393 112233073 112236125 112254479 112261120 112264737
ELS: 105012697 105013897(dhrs3) 105015937 105018873 105019615 105019635 105021270(rdh13) 105022046 105022047 105024242
SFM: 108918261 108919363 108919684 108931697 108933492 108933771(rdh13) 108935518 108935520 108938884 108941899
LCM: 102347732(RDH13) 102353614(RDH12) 102354914 102361459(DHRS3)
CMK: 103175207(rdh12) 103179224(rdh13) 103187903
BFO: BRAFLDRAFT_118764 BRAFLDRAFT_139278 BRAFLDRAFT_150455 BRAFLDRAFT_221193 BRAFLDRAFT_239950 BRAFLDRAFT_239978 BRAFLDRAFT_247684 BRAFLDRAFT_68368 BRAFLDRAFT_68398
SPU: 589814 593999
APLC: 110976160 110983988 110984991 110988383 110989984
SKO: 100368032 100370050 100375139 102804882
DSE: Dsec_GM18707
DWI: 6641201 6642626 6642799 6646241
DVI: Dvir_GJ17066 Dvir_GJ17067
BIM: 100745829
BTER: 100650146
SOC: 105195606 105195607
AEC: 105144537
ACEP: 105618447
PBAR: 105428632 105431710
HST: 105188653
DQU: 106748801
LHU: 105669716 105671265
PGC: 109857489
MDL: 103574520 103574614
TCA: 664039 664326
NVL: 108556542 108563997 108564002
DPL: KGM_205840 KGM_208720 KGM_213154
PRAP: 110999155
PXY: 105381830 105382636 105397274 105397883
API: 100166388
DNX: 107171055 107171967
CLEC: 106662430
PHU: Phum_PHUM452480 Phum_PHUM490670
ZNE: 110834190 110834193 110835668 110836709 110836719 110839626
FCD: 110842196 110854601 110854972 110856461 110857496 110863209 110863210
DPX: DAPPUDRAFT_307583 DAPPUDRAFT_41849
ISC: IscW_ISCW007540 IscW_ISCW008433 IscW_ISCW010995 IscW_ISCW011012 IscW_ISCW013705 IscW_ISCW014854 IscW_ISCW016461 IscW_ISCW016462 IscW_ISCW018859 IscW_ISCW020262 IscW_ISCW020263
NAI: NECAME_11316
HRO: HELRODRAFT_109820
LGI: LOTGIDRAFT_208859
CRG: 105320167 105323007 105341249 105342208
MYI: 110449186 110450669 110462738
OBI: 106870606 106874866 106878107 106879995
LAK: 106156832 106157569 106164481 106170305 106181051 112041252
SMM: Smp_076580 Smp_139680 Smp_203950
SHX: MS3_08851 MS3_08853 MS3_10550 MS3_11246
OVI: T265_11059 T265_15439
EPA: 110235696
ADF: 107332470
AQU: 100631596 100631723 100637836 100641757
CRB: 17895493
CSAT: 104714827 104731057 104773949
EUS: EUTSA_v10023562mg EUTSA_v10025670mg
BRP: 103838175 103838194 103861459
BNA: 106356581 106364223 106364224 106374450 106440563 111207462 111211861
BOE: 106292972 106303521 106316697 106316796
THJ: 104823251
CPAP: 110820086
CIT: 102619498
CIC: CICLE_v10021041mg
TCC: 18597799
GRA: 105799868 105801884
GHI: 107889705 107891036 107904516
DZI: 111287346
EGR: 104442518
GMX: 100794347 102670316
PVU: PHAVU_001G169500g PHAVU_002G301600g PHAVU_009G175600g
VRA: 106757059
VAR: 108322902 108322985 108330236
CCAJ: 109797500 109809382 109818471
CAM: 101509179
LJA: Lj5g3v0614340.2(Lj5g3v0614340.2)
ADU: 107472504 107494885
AIP: 107632047
LANG: 109334978 109348420 109357067
PAVI: 110762504
MDM: 103427570
PXB: 103931084
ZJU: 107431100
CMAX: 111482112
CMOS: 111442120
CPEP: 111791471
RCU: 8269384
JCU: 105636270
POP: 7457761 7487251
JRE: 109006782
VVI: 100261623
SOT: 102583799
CANN: 107842976
NTA: 107768761 107788371
NTO: 104115366
INI: 109157983 109160460
HAN: 110883127 110898239 110904384
LSV: 111911734
CCAV: 112510513 112521483 112528642
DCR: 108215406
BVG: 104892580
NNU: 104594289 104594591 104604735 104610245 104610803
BDI: 100836169
SITA: 101770964
PDA: 103695766 103707701 103714170
EGU: 105054114 105054614
MUS: 103991720
PEQ: 110026519 110027746
AOF: 109826635
ATR: 110006661
SMO: SELMODRAFT_114160 SELMODRAFT_114437 SELMODRAFT_114488 SELMODRAFT_116561 SELMODRAFT_136252 SELMODRAFT_139089 SELMODRAFT_17042 SELMODRAFT_420551
PPP: 112275358 112295066
CRE: CHLREDRAFT_191453
VCN: VOLCADRAFT_79467
MNG: MNEG_12120 MNEG_12271
OTA: OT_ostta01g05890 OT_ostta13g02190
BPG: Bathy04g02560
APRO: F751_1025
GSL: Gasu_17830 Gasu_34300
CCP: CHC_T00010090001
MRR: Moror_10748
ACAN: ACA1_381490
TET: TTHERM_00152010 TTHERM_00152020 TTHERM_00216130
PTM: GSPATT00000448001 GSPATT00003749001 GSPATT00039126001 PTMB.94
FCY: FRACYDRAFT_185817 FRACYDRAFT_244068 FRACYDRAFT_255573
SPAR: SPRG_06996 SPRG_07905 SPRG_13964
NGR: NAEGRDRAFT_30072 NAEGRDRAFT_32453 NAEGRDRAFT_33289 NAEGRDRAFT_44570 NAEGRDRAFT_44843 NAEGRDRAFT_58626 NAEGRDRAFT_76802
KAK: Kalk_16770
OME: OLMES_2705
FLM: MY04_4115
 » show all
Taxonomy
Reference
1  [PMID:15865448]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY
  Title
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.
  Journal
Biochemistry 44:7035-47 (2005)
DOI:10.1021/bi050226k
  Sequence
[hsa:145226]
Reference
2  [PMID:18039331]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY
  Title
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.
  Journal
FEBS J 275:138-47 (2008)
DOI:10.1111/j.1742-4658.2007.06184.x
  Sequence
[hsa:112724]
Reference
3  [PMID:9705317]
  Authors
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K
  Title
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.
  Journal
J Biol Chem 273:21790-9 (1998)
DOI:10.1074/jbc.273.34.21790
  Sequence
[hsa:9249] [mmu:20148] [bta:281482]
Reference
4  [PMID:12036956]
  Authors
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS
  Title
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).
  Journal
J Biol Chem 277:28909-15 (2002)
DOI:10.1074/jbc.M202588200
  Sequence
[hsa:51109]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.300
IUBMB Enzyme Nomenclature: 1.1.1.300
ExPASy - ENZYME nomenclature database: 1.1.1.300
BRENDA, the Enzyme Database: 1.1.1.300

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Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (4149)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (801)   
   KEGG MGENES (522)   
   RefGene (2772)   
   EGENES (50)   
Protein sequence (105)   
   UniProt (47)   
   SWISS-PROT (16)   
   RefSeq(pep) (42)   
DNA sequence (56)   
   RefSeq(nuc) (45)   
   GenBank (8)   
   EMBL (3)   
Protein domain (2)   
   InterPro (2)   
All databases (4319)   

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