KEGG   ENZYME: 1.1.1.307Help
Entry
EC 1.1.1.307                Enzyme                                 

Name
D-xylose reductase;
XylR;
XyrA;
msXR;
dsXR;
monospecific xylose reductase;
dual specific xylose reductase;
NAD(P)H-dependent xylose reductase;
xylose reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
xylitol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+ [RN:R01431 R09477]
Reaction(KEGG)
Substrate
xylitol [CPD:C00379];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
D-xylose [CPD:C00181];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.
History
EC 1.1.1.307 created 2010
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K17743  D-xylose reductase
Genes
SASA: 100196319(xyl1)
MIS: MICPUN_98293
SCE: YHR104W(GRE3)
AGO: AGOS_ACL107C
ERC: Ecym_5508
KLA: KLLA0_E21627g
KMX: KLMA_10683(XYL1)
LTH: KLTH0F16610g
ZRO: ZYRO0A06336g
CGR: CAGL0I01122g
NCS: NCAS_0A06660(NCAS0A06660)
NDI: NDAI_0D01600(NDAI0D01600)
TPF: TPHA_0E01860(TPHA0E01860)
TBL: TBLA_0A00630(TBLA0A00630) TBLA_0F01720(TBLA0F01720)
TDL: TDEL_0E02150(TDEL0E02150)
KAF: KAFR_0C05320(KAFR0C05320)
PIC: PICST_89614(XYL1)
SPAA: SPAPADRAFT_61339(XYL1.2) SPAPADRAFT_61341(XYL1.1)
CAL: CAALFM_C502930CA(GRE3)
CDU: CD36_52690(XYRA)
CAUR: QG37_02715
SLB: AWJ20_3140(GRE3)
NCR: NCU08384(xr)
NTE: NEUTE1DRAFT133088(NEUTE1DRAFT_133088)
SSCK: SPSK_06315
TRE: TRIREDRAFT_107776(xyl1)
MAJ: MAA_00542
ANI: AN0423.2
ANG: ANI_1_2444014(An01g03740)
ABE: ARB_06141
TVE: TRV_03808
PTE: PTT_08729
AMAC: MASE_18010
AAUS: EP12_18925
GPS: C427_1732
PIR: VN12_20240(ytbE)
PLS: VT03_22870(ytbE)
FMR: Fuma_05200(dkgA)
SACI: Sinac_2429
 » show all
Taxonomy
Reference
1  [PMID:9307017]
  Authors
Neuhauser W, Haltrich D, Kulbe KD, Nidetzky B
  Title
NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme.
  Journal
Biochem J 326 ( Pt 3):683-92 (1997)
Reference
2  [PMID:14690376]
  Authors
Nidetzky B, Bruggler K, Kratzer R, Mayr P
  Title
Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies.
  Journal
J Agric Food Chem 51:7930-5 (2003)
DOI:10.1021/jf034426j
Reference
3  [PMID:14526534]
  Authors
Iablochkova EN, Bolotnikova OI, Mikhailova NP, Nemova NN, Ginak AI
  Title
[The activity of xylose reductase and xylitol dehydrogenase in yeasts]
  Journal
Mikrobiologiia 72:466-9 (2003)
Reference
4  [PMID:19342796]
  Authors
Chen LC, Huang SC, Chuankhayan P, Chen CD, Huang YC, Jeyakanthan J, Pang HF, Men LC, Chen YC, Wang YK, Liu MY, Wu TK, Chen CJ
  Title
Purification, crystallization and preliminary X-ray crystallographic analysis of  xylose reductase from Candida tropicalis.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 65:419-21 (2009)
DOI:10.1107/S1744309109008719
  Sequence
Reference
5  [PMID:3921014]
  Authors
Verduyn C, Van Kleef R, Frank J, Schreuder H, Van Dijken JP, Scheffers WA
  Title
Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis.
  Journal
Biochem J 226:669-77 (1985)
  Sequence
Reference
6  [PMID:20093741]
  Authors
Fernandes S, Tuohy MG, Murray PG
  Title
Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and  heterologous expression of the native gene (Texr) and a double mutant (TexrK271R  + N273D) with altered coenzyme specificity.
  Journal
J Biosci 34:881-90 (2009)
Reference
7  [PMID:14532079]
  Authors
Lee JK, Koo BS, Kim SY
  Title
Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis.
  Journal
Appl Environ Microbiol 69:6179-88 (2003)
DOI:10.1128/AEM.69.10.6179-6188.2003
  Sequence
Reference
8  [PMID:15746370]
  Authors
Woodyer R, Simurdiak M, van der Donk WA, Zhao H
  Title
Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa.
  Journal
Appl Environ Microbiol 71:1642-7 (2005)
DOI:10.1128/AEM.71.3.1642-1647.2005
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.307
IUBMB Enzyme Nomenclature: 1.1.1.307
ExPASy - ENZYME nomenclature database: 1.1.1.307
BRENDA, the Enzyme Database: 1.1.1.307

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