KEGG   ENZYME: 1.5.3.19Help
Entry
EC 1.5.3.19                 Enzyme                                 

Name
4-methylaminobutanoate oxidase (formaldehyde-forming);
mabO (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2 [RN:R10102]
Reaction(KEGG)
Substrate
4-methylaminobutanoate;
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
4-aminobutanoate [CPD:C00334];
formaldehyde [CPD:C00067];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). In the enzyme from the soil bacterium Arthrobacter nicotinovorans the cofactor is covalently bound. Participates in the nicotine degradation pathway of this organism.
History
EC 1.5.3.19 created 2012
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K19191  4-methylaminobutanoate oxidase (formaldehyde-forming)
Genes
ARX: ARZXY2_4583
Taxonomy
Reference
1  [PMID:15606755]
  Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
  Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism  of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
  Journal
Eur J Biochem 271:4677-84 (2004)
DOI:10.1111/j.1432-1033.2004.04432.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.19
IUBMB Enzyme Nomenclature: 1.5.3.19
ExPASy - ENZYME nomenclature database: 1.5.3.19
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.3.19
BRENDA, the Enzyme Database: 1.5.3.19

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