KEGG   ENZYME: 1.8.1.14Help
Entry
EC 1.8.1.14                 Enzyme                                 

Name
CoA-disulfide reductase;
CoA-disulfide reductase (NADH2);
NADH2:CoA-disulfide oxidoreductase;
CoA:NAD+ oxidoreductase (misleading);
CoADR;
coenzyme A disulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
CoA:NADP+ oxidoreductase
Reaction(IUBMB)
2 CoA + NADP+ = CoA-disulfide + NADPH + H+ [RN:R07175]
Reaction(KEGG)
Substrate
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
CoA-disulfide [CPD:C02015];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein. Not identical with EC 1.8.1.6 (cystine reductase), EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.13 (bis-gamma-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1].
History
EC 1.8.1.14 created 1992 as EC 1.6.4.10, transferred 2002 to EC 1.8.1.14, modified 2005, modified 2013
Orthology
K08255  CoA-disulfide reductase
Genes
SAU: SA0831(cdr)
SAV: SAV0970(cdr)
SAW: SAHV_0965(cdr)
SAH: SaurJH1_0989
SAJ: SaurJH9_0970
SAM: MW0852(cdr)
SAS: SAS0840
SAR: SAR0933
SAC: SACOL0975
SAX: USA300HOU_0929(cdr)
SAA: SAUSA300_0873(cdr)
SAE: NWMN_0841(cdr)
SAD: SAAV_0931
SUC: ECTR2_826(cdr)
SUQ: HMPREF0772_12275(cdr)
SUZ: MS7_0926(cdr)
SUG: SAPIG0970(cdr)
SAUA: SAAG_01324
SAUS: SA40_0837
SAUU: SA957_0852
SAUG: SA268_0852
SAUT: SAI1T1_2006800(cdr)
SAUJ: SAI2T2_1006820(cdr)
SAUK: SAI3T3_1006810(cdr)
SAUQ: SAI4T8_1006800(cdr)
SAUV: SAI7S6_1006810(cdr)
SAUW: SAI5S5_1006770(cdr)
SAUX: SAI6T6_1006780(cdr)
SAUY: SAI8T7_1006810(cdr)
SAUF: X998_0969
SAB: SAB0839c
SUY: SA2981_0925(cdr)
SAUB: C248_0996
SAUM: BN843_8750
SAUC: CA347_891(cdr)
SAUR: SABB_00939(cdr)
SAUI: AZ30_04610
SAUD: CH52_01025
SAMS: NI36_04595
SEP: SE0669
SER: SERP0560
SEPP: SEB_00649
SEPS: DP17_1962(cdr)
SHA: SH1979(cdr)
SSP: SSP1804
SCA: SCA_0578(cdr)
SDT: SPSE_1865(cdr)
SPAS: STP1_2052
SXO: SXYL_01950(cdr)
SHU: SHYC_09425(cdr)
SCAP: AYP1020_0240(cdr)
SSCH: LH95_08910
SSCZ: RN70_09390
SAGQ: EP23_00565
MCL: MCCL_0597(cdr)
MCAK: MCCS_08170(cdr_2)
 » show all
Taxonomy
Reference
1  [PMID:410791]
  Authors
Setlow B, Setlow P.
  Title
Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium.
  Journal
J Bacteriol 132:444-52 (1977)
Reference
2  [PMID:9488707]
  Authors
delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE.
  Title
Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme.
  Journal
J Biol Chem 273:5744-51 (1998)
DOI:10.1074/jbc.273.10.5744
  Sequence
Reference
3  [PMID:10052943]
  Authors
Luba J, Charrier V, Claiborne A.
  Title
Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides.
  Journal
Biochemistry 38:2725-37 (1999)
DOI:10.1021/bi9825899
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.14
IUBMB Enzyme Nomenclature: 1.8.1.14
ExPASy - ENZYME nomenclature database: 1.8.1.14
BRENDA, the Enzyme Database: 1.8.1.14
CAS: 206770-55-0

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