KEGG   ENZYME: 2.1.1.68Help
Entry
EC 2.1.1.68                 Enzyme                                 

Name
caffeate O-methyltransferase;
caffeate methyltransferase;
caffeate 3-O-methyltransferase;
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate [RN:R03366]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3,4-dihydroxy-trans-cinnamate [CPD:C01197]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-4-hydroxy-trans-cinnamate [CPD:C01494]
Comment
3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.
History
EC 2.1.1.68 created 1984
Pathway
ec00940  Phenylpropanoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13066  caffeic acid 3-O-methyltransferase
Genes
ATH: AT5G54160(OMT1)
ALY: ARALYDRAFT_495497(ATOMT1)
CRB: 17876808
EUS: EUTSA_v10013897mg
CIT: 102629858
CIC: CICLE_v10001661mg CICLE_v10024037mg CICLE_v10031951mg
DZI: 111279932 111289581
GMX: 100780100 100805999(GMIMT1) 100806525
PVU: PHAVU_009G044400g
MTR: MTR_3g092900
CAM: 101489645
FVE: 101308514
PMUM: 103333559
MDM: 103439955
CSV: 101204109
CMO: 103501180
CMOS: 111450048
RCU: 8282965
JRE: 109007527
SLY: 101251452
SOT: 102601955
OEU: 111367736
SMO: SELMODRAFT_450944(COMT1-1) SELMODRAFT_450945(COMT1-2)
 » show all
Taxonomy
Reference
1  [PMID:4472044]
  Authors
Ebel J, Schaller-Hekeler B, Knobloch KH, Wellman E, Grisebach H, Hahlbrock K.
  Title
Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures.
  Journal
Biochim Biophys Acta 362:417-24 (1974)
DOI:10.1016/0304-4165(74)90137-8
Reference
2  [PMID:241400]
  Authors
Poulton JE, Butt VS.
  Title
Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L).
  Journal
Biochim Biophys Acta 403:301-14 (1975)
DOI:10.1016/0005-2744(75)90060-1
Reference
3
  Authors
Shimada, M., Kuroda, H. and Higuchi, T.
  Title
Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase.
  Journal
Phytochemistry 12:2873-2875 (1973)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.68
IUBMB Enzyme Nomenclature: 2.1.1.68
ExPASy - ENZYME nomenclature database: 2.1.1.68
BRENDA, the Enzyme Database: 2.1.1.68
CAS: 50936-45-3

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