KEGG   ENZYME: 2.3.1.176Help
Entry
EC 2.3.1.176                Enzyme                                 

Name
propanoyl-CoA C-acyltransferase;
SCP2 (gene name);
peroxisomal thiolase 2;
sterol carrier protein-chi;
SCPchi;
PTE-2 (ambiguous);
propionyl-CoA C2-trimethyltridecanoyltransferase;
3-oxopristanoyl-CoA hydrolase;
3-oxopristanoyl-CoA thiolase;
peroxisome sterol carrier protein thiolase;
sterol carrier protein;
oxopristanoyl-CoA thiolase;
peroxisomal 3-oxoacyl coenzyme A thiolase;
SCPx;
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
Reaction(IUBMB)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [RN:R03719]
Reaction(KEGG)
Substrate
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA [CPD:C01794];
propanoyl-CoA [CPD:C00100]
Product
CoA [CPD:C00010];
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [CPD:C05467]
Comment
Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [3].
History
EC 2.3.1.176 created 2005 (EC 2.3.1.154 created 2000, incorporated 2015)
Pathway
ec00120  Primary bile acid biosynthesis
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
Orthology
K08764  sterol carrier protein 2
Genes
HSA: 6342(SCP2)
PTR: 456862(SCP2)
PPS: 100986541(SCP2)
GGO: 101143883(SCP2)
PON: 100173072(SCP2)
NLE: 100597097(SCP2)
MCC: 715765(SCP2)
MCF: 102140312(SCP2)
CSAB: 103224800(SCP2)
RRO: 104669256(SCP2)
RBB: 108531191(SCP2)
CJC: 100388218(SCP2)
SBQ: 101036680(SCP2)
MMU: 20280(Scp2)
RNO: 25541(Scp2)
CGE: 100757558(Scp2)
NGI: 103730241(Scp2)
HGL: 101705283(Scp2)
CCAN: 109693360(Scp2)
OCU: 100008683(SCP2)
TUP: 102487249(SCP2)
CFA: 479564(SCP2)
AML: 100469567(SCP2)
UMR: 103670702(SCP2)
ORO: 101367151(SCP2)
FCA: 101093036(SCP2)
PTG: 102951550(SCP2)
AJU: 106987886(SCP2)
BTA: 508918(SCP2)
BIU: 109556283(SCP2)
PHD: 102322180
CHX: 102182369(SCP2)
OAS: 101117285(SCP2)
SSC: 397439(SCP2)
CDK: 105090773(SCP2)
BACU: 103008562(SCP2)
OOR: 101279314(SCP2)
ECB: 100061338(SCP2)
EPZ: 103558615(SCP2) 103566497
EAI: 106833182(SCP2)
MYB: 102242920(SCP2)
MYD: 102765227(SCP2)
HAI: 109395424(SCP2)
RSS: 109453228(SCP2)
PALE: 102884769(SCP2)
TMU: 101347488
MDO: 100017946(SCP2)
SHR: 100922562(SCP2)
GGA: 396550(SCP2)
MGP: 100541979(SCP2)
CJO: 107317654(SCP2)
APLA: 101803933(SCP2)
ACYG: 106032940(SCP2)
TGU: 100218387(SCP2)
GFR: 102042799(SCP2)
FAB: 101820874(SCP2)
PHI: 102105546(SCP2)
PMAJ: 107208151(SCP2)
CCAE: 111933041(SCP2)
CCW: 104695523(SCP2)
FPG: 101913645(SCP2)
FCH: 102053527(SCP2)
CLV: 102087499(SCP2)
EGZ: 104131500(SCP2)
AAM: 106491062(SCP2)
ASN: 102377979(SCP2)
AMJ: 102570791(SCP2)
PSS: 102461487(SCP2)
CPIC: 101937963(SCP2)
ACS: 100559527(scp2)
PVT: 110082239(SCP2)
PBI: 103053379(SCP2)
GJA: 107120559(SCP2)
XLA: 108715604 494715(scp2.L)
XTR: 548512(scp2)
NPR: 108783818(SCP2)
DRE: 393839(scp2a)
SGH: 107577646 107593851(scp2)
IPU: 108267621(scp2) 108275753
AMEX: 103022159(scp2) 103033749
TRU: 101069006(scp2)
LCO: 104921750 104936979(scp2)
NCC: 104949681(scp2) 104953196
MZE: 101474585 101481799(scp2)
OLA: 101172485 101175107(scp2)
XMA: 102226285 102237220(scp2)
PRET: 103464006 103479011(scp2)
NFU: 107384403 107387357(scp2)
KMR: 108238206(scp2) 108246649
CSEM: 103395834(scp2) 103398772
SDU: 111228861(scp2) 111231890
HCQ: 109509280 109521343(scp2)
BPEC: 110173449(scp2) 110173461
MALB: 109965786 109970643(scp2)
ELS: 105005901 105022798(scp2)
SFM: 108935159(scp2)
CMK: 103185291(scp2)
SPU: 576367
APLC: 110986063
SKO: 100368127(SCP2) 100368276
DME: Dmel_CG17320(ScpX) Dmel_CG17597(CG17597)
DSI: Dsimw501_GD21807(Dsim_GD21807)
MDE: 101899830
AAG: 5575668
AME: 408904
BIM: 100748275
BTER: 100647066
SOC: 105201416
AEC: 105153563
ACEP: 105618569
PBAR: 105432859
HST: 105189995
DQU: 106742407
CFO: 105251216
LHU: 105675589
PGC: 109861339
PCF: 106788866
NVI: 100123951
MDL: 103571215
TCA: 657233(Scpx)
DPA: 109539789
NVL: 108556749
BMOR: 692782(Scpx)
PRAP: 110993930
HAW: 110373174
PXY: 105382506
DNX: 107161308
CLEC: 106670708
ZNE: 110831910
FCD: 110850871
TUT: 107367461
CEL: CELE_Y57A10C.6(daf-22)
CBR: CBG20965
BMY: Bm1_53275
MYI: 110461537
OBI: 106877352
AQU: 100638133
NCR: NCU03372
NTE: NEUTE1DRAFT84532(NEUTE1DRAFT_84532)
MGR: MGG_02409
SSCK: SPSK_02507
MAW: MAC_03561
MAJ: MAA_02626
MBE: MBM_04974
ANG: ANI_1_216184(An04g00740)
PBL: PAAG_11860(PAAG_04374)
ABE: ARB_01676
TVE: TRV_00032
ABP: AGABI1DRAFT110046(AGABI1DRAFT_110046)
ABV: AGABI2DRAFT190063(AGABI2DRAFT_190063)
 » show all
Taxonomy
Reference
1  [PMID:7461136]
  Authors
Pedersen JI, Gustafsson J.
  Title
Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes.
  Journal
FEBS Lett 121:345-8 (1980)
DOI:10.1016/0014-5793(80)80377-2
Reference
2  [PMID:6668450]
  Authors
Kase F, Bjorkhem I, Pedersen JI.
  Title
Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.
  Journal
J Lipid Res 24:1560-7 (1983)
Reference
3  [PMID:8034703]
  Authors
Falany CN, Johnson MR, Barnes S, Diasio RB.
  Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
  Journal
J Biol Chem 269:19375-9 (1994)
Reference
4  [PMID:8063752]
  Authors
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G.
  Title
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.
  Journal
J Biol Chem 269:21277-83 (1994)
Reference
5  [PMID:9245689]
  Authors
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U.
  Title
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.
  Journal
Biochem Biophys Res Commun 236:565-9 (1997)
DOI:10.1006/bbrc.1997.7007
Reference
6  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.176
IUBMB Enzyme Nomenclature: 2.3.1.176
ExPASy - ENZYME nomenclature database: 2.3.1.176
BRENDA, the Enzyme Database: 2.3.1.176

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