KEGG   ENZYME: 2.3.1.176Help
Entry
EC 2.3.1.176                Enzyme                                 

Name
propanoyl-CoA C-acyltransferase;
SCP2 (gene name);
peroxisomal thiolase 2;
sterol carrier protein-chi;
SCPchi;
PTE-2 (ambiguous);
propionyl-CoA C2-trimethyltridecanoyltransferase;
3-oxopristanoyl-CoA hydrolase;
3-oxopristanoyl-CoA thiolase;
peroxisome sterol carrier protein thiolase;
sterol carrier protein;
oxopristanoyl-CoA thiolase;
peroxisomal 3-oxoacyl coenzyme A thiolase;
SCPx;
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
Reaction(IUBMB)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [RN:R03719]
Reaction(KEGG)
R03719 > R04811;
(other) R05330
Show
Substrate
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA [CPD:C01794];
propanoyl-CoA [CPD:C00100]
Product
CoA [CPD:C00010];
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [CPD:C05467]
Comment
Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [3].
History
EC 2.3.1.176 created 2005 (EC 2.3.1.154 created 2000, incorporated 2015)
Pathway
ec00120  Primary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K08764  sterol carrier protein 2
Genes
HSA: 6342(SCP2)
PTR: 456862(SCP2)
PPS: 100986541(SCP2)
GGO: 101143883(SCP2)
PON: 100173072(SCP2)
NLE: 100597097(SCP2)
MCC: 715765(SCP2)
MCF: 102140312(SCP2)
CSAB: 103224800(SCP2)
RRO: 104669256(SCP2)
RBB: 108531191(SCP2)
CJC: 100388218(SCP2)
SBQ: 101036680(SCP2)
MMU: 20280(Scp2)
RNO: 25541(Scp2)
CGE: 100757558(Scp2)
NGI: 103730241(Scp2)
HGL: 101705283(Scp2)
CCAN: 109693360(Scp2)
OCU: 100008683(SCP2)
TUP: 102487249(SCP2)
CFA: 479564(SCP2)
AML: 100469567(SCP2)
UMR: 103670702(SCP2)
ORO: 101367151(SCP2)
FCA: 101093036(SCP2)
PTG: 102951550(SCP2)
AJU: 106987886(SCP2)
BTA: 508918(SCP2)
BIU: 109556283(SCP2)
PHD: 102322180
CHX: 102182369(SCP2)
OAS: 101117285(SCP2)
SSC: 397439(SCP2)
CDK: 105090773(SCP2)
BACU: 103008562(SCP2)
OOR: 101279314(SCP2)
ECB: 100061338(SCP2)
EPZ: 103558615(SCP2) 103566497
EAI: 106833182(SCP2)
MYB: 102242920(SCP2)
MYD: 102765227(SCP2)
HAI: 109395424(SCP2)
RSS: 109453228(SCP2)
PALE: 102884769(SCP2)
TMU: 101347488
MDO: 100017946(SCP2)
SHR: 100922562(SCP2)
GGA: 396550(SCP2)
MGP: 100541979(SCP2)
CJO: 107317654(SCP2)
APLA: 101803933(SCP2)
ACYG: 106032940(SCP2)
TGU: 100218387(SCP2)
GFR: 102042799(SCP2)
FAB: 101820874(SCP2)
PHI: 102105546(SCP2)
PMAJ: 107208151(SCP2)
CCW: 104695523(SCP2)
FPG: 101913645(SCP2)
FCH: 102053527(SCP2)
CLV: 102087499(SCP2)
EGZ: 104131500(SCP2)
AAM: 106491062(SCP2)
ASN: 102377979(SCP2)
AMJ: 102570791(SCP2)
PSS: 102461487(SCP2)
CPIC: 101937963(SCP2)
ACS: 100559527(scp2)
PVT: 110082239(SCP2)
PBI: 103053379(SCP2)
GJA: 107120559(SCP2)
XLA: 108715604 494715(scp2.L)
XTR: 548512(scp2)
NPR: 108783818(SCP2)
DRE: 393839(scp2a)
SGH: 107577646 107593851(scp2)
IPU: 108267621(scp2) 108275753
AMEX: 103022159(scp2) 103033749
TRU: 101069006(scp2)
LCO: 104921750 104936979(scp2)
NCC: 104949681(scp2) 104953196
MZE: 101474585 101481799(scp2)
OLA: 101172485 101175107(scp2)
XMA: 102226285 102237220(scp2)
PRET: 103464006 103479011(scp2)
NFU: 107384403 107387357(scp2)
CSEM: 103395834(scp2) 103398772
HCQ: 109509280 109521343(scp2)
BPEC: 110173449(scp2) 110173461
ELS: 105005901 105022798(scp2)
SFM: 108935159(scp2)
CMK: 103185291(scp2)
SPU: 576367
APLC: 110986063
SKO: 100368127(SCP2) 100368276
DME: Dmel_CG17320(ScpX) Dmel_CG17597(CG17597)
DSI: Dsimw501_GD21807(Dsim_GD21807)
MDE: 101899830
AAG: 5575668
AME: 408904
BIM: 100748275
BTER: 100647066
SOC: 105201416
AEC: 105153563
ACEP: 105618569
PBAR: 105432859
HST: 105189995
CFO: 105251216
LHU: 105675589
PGC: 109861339
NVI: 100123951
TCA: 657233(Scpx)
DPA: 109539789
NVL: 108556749
BMOR: 692782(Scpx)
PRAP: 110993930
PXY: 105382506
DNX: 107161308
ZNE: 110831910
FCD: 110850871
TUT: 107367461
CEL: CELE_Y57A10C.6(daf-22)
CBR: CBG20965
BMY: Bm1_53275
MYI: 110461537
OBI: 106877352
AQU: 100638133
NCR: NCU03372
NTE: NEUTE1DRAFT84532(NEUTE1DRAFT_84532)
MGR: MGG_02409
SSCK: SPSK_02507
MAW: MAC_03561
MAJ: MAA_02626
MBE: MBM_04974
ANG: ANI_1_216184(An04g00740)
PBL: PAAG_11860(PAAG_04374)
ABE: ARB_01676
TVE: TRV_00032
ABP: AGABI1DRAFT110046(AGABI1DRAFT_110046)
ABV: AGABI2DRAFT190063(AGABI2DRAFT_190063)
 » show all
Taxonomy
Reference
1  [PMID:7461136]
  Authors
Pedersen JI, Gustafsson J.
  Title
Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes.
  Journal
FEBS Lett 121:345-8 (1980)
DOI:10.1016/0014-5793(80)80377-2
Reference
2  [PMID:6668450]
  Authors
Kase F, Bjorkhem I, Pedersen JI.
  Title
Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.
  Journal
J Lipid Res 24:1560-7 (1983)
Reference
3  [PMID:8034703]
  Authors
Falany CN, Johnson MR, Barnes S, Diasio RB.
  Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
  Journal
J Biol Chem 269:19375-9 (1994)
Reference
4  [PMID:8063752]
  Authors
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G.
  Title
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.
  Journal
J Biol Chem 269:21277-83 (1994)
Reference
5  [PMID:9245689]
  Authors
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U.
  Title
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.
  Journal
Biochem Biophys Res Commun 236:565-9 (1997)
DOI:10.1006/bbrc.1997.7007
Reference
6  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.176
IUBMB Enzyme Nomenclature: 2.3.1.176
ExPASy - ENZYME nomenclature database: 2.3.1.176
BRENDA, the Enzyme Database: 2.3.1.176

DBGET integrated database retrieval system