KEGG   ENZYME: 2.3.1.23Help
Entry
EC 2.3.1.23                 Enzyme                                 

Name
1-acylglycerophosphocholine O-acyltransferase;
lysolecithin acyltransferase;
1-acyl-sn-glycero-3-phosphocholine acyltransferase;
acyl coenzyme A-monoacylphosphatidylcholine acyltransferase;
acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase;
lysophosphatide acyltransferase;
lysophosphatidylcholine acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine [RN:R01318]
Reaction(KEGG)
R01318;
(other) R03438 R04480
Show
Substrate
acyl-CoA [CPD:C00040];
1-acyl-sn-glycero-3-phosphocholine [CPD:C04230]
Product
CoA [CPD:C00010];
1,2-diacyl-sn-glycero-3-phosphocholine [CPD:C00157]
Comment
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
History
EC 2.3.1.23 created 1972
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K13510  lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase
K13512  lysophospholipid acyltransferase
K13515  lysophospholipid acyltransferase 5
K13519  lysophospholipid acyltransferase
Genes
HSA: 10162(LPCAT3) 254531(LPCAT4) 54947(LPCAT2) 79888(LPCAT1)
PTR: 451807(LPCAT3) 453302(LPCAT4) 454095(LPCAT2) 461698(LPCAT1)
PPS: 100970278(LPCAT2) 100991640(LPCAT3) 100991866(LPCAT1) 100994535(LPCAT4)
GGO: 101125811(LPCAT1) 101138654(LPCAT3) 101146143(LPCAT4) 101148534(LPCAT2)
PON: 100435855(LPCAT1) 100438914(LPCAT4) 100449193(LPCAT3) 100449928(LPCAT2)
NLE: 100587878(LPCAT4) 100597870(CAPNS2) 100598156(LPCAT3) 100600471(LPCAT1)
MCC: 696388(LPCAT4) 698605(LPCAT2) 710144(LPCAT1) 714639(LPCAT3)
MCF: 102125601(LPCAT2) 102134967(LPCAT4) 102135286(LPCAT3) 102143549(LPCAT1)
CSAB: 103214933(LPCAT1) 103218496(LPCAT3) 103225898 103233009(LPCAT2) 103245902(LPCAT4)
RRO: 104668709(LPCAT1) 104671480(LPCAT2) 104680083(LPCAT3) 104680372(LPCAT4)
RBB: 108513712(LPCAT1) 108517697 108518804(LPCAT4) 108531262(LPCAT2) 108542026(LPCAT3)
CJC: 100389756(LPCAT2) 100393606(LPCAT1) 100407109(LPCAT4) 100411203(LPCAT3)
SBQ: 101032098(LPCAT1) 101034415(LPCAT3) 101038984(LPCAT4) 101042520(LPCAT2)
MMU: 14792(Lpcat3) 210992(Lpcat1) 270084(Lpcat2) 70902(Lpcat2b) 99010(Lpcat4)
RNO: 100359680(Lpcat2) 289439(Lpcat2b) 296048(Lpcat4) 361467(Lpcat1) 362434(Lpcat3)
NGI: 103727490(Lpcat3) 103731684(Lpcat2) 103740499(Lpcat4) 103749677(Lpcat1)
HGL: 101696607(Lpcat2) 101696621(Lpcat3) 101703809(Lpcat4) 101709594(Lpcat1)
CCAN: 109678676(Lpcat1) 109682815(Lpcat3) 109689425(Lpcat4) 109690724(Lpcat2) 109698670
OCU: 100341001(LPCAT2) 100342288(LPCAT3) 103346634(LPCAT1) 108178277(LPCAT4)
TUP: 102469903(LPCAT1) 102483475(LPCAT2) 102490658 102497710(LPCAT3) 102501722(LPCAT4)
CFA: 478238(LPCAT4) 486715(LPCAT3) 488066(LPCAT1) 611330(LPCAT2)
AML: 100464874(LPCAT2) 100471481(LPCAT4) 100472770(LPCAT3) 100480167(LPCAT1)
UMR: 103656177(LPCAT3) 103673562(LPCAT4) 103673788(LPCAT2) 103679260(LPCAT1)
ORO: 101362482(LPCAT1) 101375900(LPCAT3) 101377840(LPCAT2) 101385159(LPCAT4)
FCA: 101088419(LPCAT3) 101090943(LPCAT4) 101095078(LPCAT1) 101099093(LPCAT2)
PTG: 102949323(LPCAT4) 102949335(LPCAT3) 102959706(LPCAT2) 102971071(LPCAT1)
AJU: 106965339(LPCAT3) 106969897(LPCAT4) 106973282(LPCAT2) 106985126(LPCAT1)
BTA: 510842(LPCAT4) 514646(LPCAT2) 515361(LPCAT3) 788450(LPCAT1)
BOM: 102265598(LPCAT1) 102268140 102269060(LPCAT2) 102284746(LPCAT3) 102287873(LPCAT4)
BIU: 109556810 109558904(LPCAT3) 109564889(LPCAT4) 109572861(LPCAT2) 109574742(LPCAT1)
PHD: 102315143(LPCAT2) 102325886(LPCAT3) 102334493(LPCAT4) 102336330(LPCAT1)
CHX: 102178967 102184933(LPCAT2) 102186907(LPCAT1) 102190030(LPCAT3) 102190522(LPCAT4)
OAS: 101108119(LPCAT3) 101110515(LPCAT4) 101111661(LPCAT1) 101115816(LPCAT2) 101116368 101120465
SSC: 100152542(LPCAT4) 100217397(LPCAT1) 100517894(LPCAT2) 100627653(LPCAT3)
CFR: 102507320(LPCAT4) 102509280(LPCAT1) 102510009(LPCAT2) 102516118(LPCAT3) 102522183
CDK: 105085760 105089972(LPCAT4) 105097505(LPCAT2) 105098189(LPCAT3) 105102173(LPCAT1)
BACU: 103001888(LPCAT1) 103004749(LPCAT3) 103009997(LPCAT4) 103016463(LPCAT2)
LVE: 103071483(LPCAT2) 103079269 103081151(LPCAT4) 103085861(LPCAT3) 103087358(LPCAT1)
OOR: 101271933(LPCAT4) 101275731(LPCAT2) 101288915(LPCAT1) 101289522 101290229(LPCAT3)
ECB: 100053035(LPCAT3) 100060157 100061308(LPCAT2) 100071891(LPCAT4) 100071898(LPCAT1)
EPZ: 103547035(LPCAT3) 103548521(LPCAT4) 103553196(LPCAT2) 103553726 103567497(LPCAT1)
EAI: 106822468(LPCAT2) 106835136(LPCAT4) 106835899(LPCAT1) 106846498 106847310(LPCAT3)
MYB: 102244268(LPCAT1) 102244920(LPCAT4) 102245573 102256221(LPCAT3) 102259694(LPCAT2)
MYD: 102755432(LPCAT3) 102766895(LPCAT4) 102767459(LPCAT2) 102771533(LPCAT1) 102774257
HAI: 109371697(LPCAT1) 109373253 109373439(LPCAT4) 109373659(LPCAT3) 109395625(LPCAT2)
RSS: 109441105 109442046 109454189(LPCAT1) 109457117(LPCAT2) 109458550 109458886(LPCAT4) 109459684(LPCAT3)
PALE: 102884144(LPCAT2) 102884265(LPCAT4) 102894173 102894763(LPCAT1) 102896872(LPCAT3)
LAV: 100653557(LPCAT3) 100654157(LPCAT4) 100659656 100675219(LPCAT2) 100675458(LPCAT1)
MDO: 100014768(LPCAT2) 100015539(LPCAT1) 100016730(LPCAT3) 100031531(LPCAT4)
SHR: 100915216(LPCAT1) 100919196(LPCAT4) 100924769(LPCAT3) 100935270(LPCAT2)
OAA: 100074850(LPCAT1) 100077162(LPCAT2) 100083365(LPCAT4) 100084970(LPCAT3)
GGA: 415716(LPCAT2) 418293(LPCAT3) 420974(LPCAT1)
MGP: 100541281(LPCAT3) 100546916(LPCAT2) 100547104(LPCAT1)
CJO: 107309445(LPCAT1) 107318603(LPCAT3) 107319184(LPCAT2)
APLA: 101791589(LPCAT3) 101791762(LPCAT1) 101802263(LPCAT2)
ACYG: 106043072 106045027(LPCAT1) 106047840(LPCAT3)
TGU: 100218938(LPCAT2) 100224379(LPCAT1) 100225934 100231699
GFR: 102037826(LPCAT2) 102041216(LPCAT3) 102044114(LPCAT1)
FAB: 101811593(LPCAT2) 101812408(LPCAT3) 101820727(LPCAT1)
PHI: 102106876(LPCAT2) 102107582(LPCAT1) 102112295(LPCAT3)
PMAJ: 107200159(LPCAT1) 107207104(LPCAT3) 107209745(LPCAT2)
CCAE: 111925329(LPCAT1) 111934581(LPCAT2) 111938172(LPCAT3)
CCW: 104685842(LPCAT1) 104687134(LPCAT3) 104687552(LPCAT2)
FPG: 101911522(LPCAT2) 101912706(LPCAT1) 101919880(LPCAT3)
FCH: 102050532(LPCAT2) 102054777(LPCAT3) 102059927(LPCAT1)
CLV: 102085502(LPCAT3) 102092846(LPCAT2) 102093144(LPCAT1)
EGZ: 104125183(LPCAT2) 104126543(LPCAT3) 104128509(LPCAT1)
AAM: 106483282(LPCAT2) 106492898(LPCAT1) 106497265(LPCAT3)
ASN: 102373866(LPCAT3) 102376020(LPCAT2) 102379638(LPCAT1) 102382492(LPCAT4)
AMJ: 102561877(LPCAT1) 102563556(LPCAT4) 102571041(LPCAT3) 102574060(LPCAT2)
PSS: 102450224(LPCAT1) 102458699 102460515(LPCAT3) 102462907(LPCAT2)
CMY: 102930396(LPCAT1) 102931433(LPCAT2) 102933144(LPCAT3) 102933145(LPCAT4)
CPIC: 101940623(LPCAT2) 101940719(LPCAT4) 101944358(LPCAT3) 101948289(LPCAT1)
ACS: 100557762(lpcat2) 100560524(lpcat3) 100563014(lpcat1) 100564138(lpcat4)
PVT: 110080886(LPCAT1) 110084653(LPCAT3) 110090095(LPCAT2) 110091387(LPCAT4)
PBI: 103055075(LPCAT4) 103056089 103057915 103062877(LPCAT1) 103065282(LPCAT3)
GJA: 107108346(LPCAT2) 107111733(LPCAT4) 107116802(LPCAT3) 107123976(LPCAT1)
XLA: 108715133(lpcat4.L) 108715344(lpcat2.S) 108720037(lpcat1.S) 446240(lpcat4.S) 447297(lpcat3.S) 496208(lpcat3.L)
XTR: 100124943(lpcat2) 100487143(lpcat1) 100498491(lpcat3) 548367(lpcat4)
NPR: 108784381(LPCAT3) 108788452(LPCAT4) 108795131(LPCAT1) 108797887(LPCAT2) 108802237
DRE: 327566(lpcat4) 553683(lpcat2) 555566(lpcat3) 555969(lpcat1)
IPU: 108259642(lpcat2) 108261003(lpcat4) 108266630(lpcat3) 108272334(lpcat1) 108272386
AMEX: 103025479(lpcat1) 103025629 103027610(lpcat3) 103030572(lpcat4)
TRU: 101067621(lpcat2) 101069240(lpcat4) 101073378 101074488(lpcat3) 101078533
LCO: 104922776 104926947(lpcat2) 104932537(lpcat3) 104933549(lpcat4) 104940425(lpcat1) 109141540
OLA: 101154975(lpcat3) 101159130(lpcat1) 101161012 101172965(lpcat2)
XMA: 102224007 102224962(lpcat4) 102226601(lpcat2) 102233875 102235292(lpcat3)
PRET: 103462669(lpcat2) 103472058 103477986(lpcat3) 103478378 103480372(lpcat4)
NFU: 107373645 107376986(lpcat4) 107378745 107379474(lpcat3) 107381257(lpcat2)
KMR: 108232307 108235414(lpcat3) 108238716 108240272(lpcat2) 108248608(lpcat4)
CSEM: 103378987(lpcat2) 103384605(lpcat4) 103387963(lpcat3) 103388333 103394104
LCF: 108877047(lpcat2) 108880739(lpcat3) 108889071 108890748(lpcat4) 108900423
SDU: 111219107(lpcat2) 111227743 111230069(lpcat3) 111233198 111238596(lpcat4)
BPEC: 110158302(lpcat4) 110163017(lpcat3) 110167472 110171644 110175236(lpcat2)
MALB: 109952022(lpcat4) 109955890(lpcat2) 109958224 109966229(lpcat3) 109971720
ELS: 105012400(lpcat1) 105016610 105023459(lpcat2) 105028246(lpcat3) 105030102(lpcat4)
SFM: 108919238 108922088(lpcat3) 108928303(lpcat2) 108930628(lpcat4) 108940486(lpcat1)
LCM: 102350271(LPCAT2) 102355729(LPCAT3) 102364428(LPCAT1) 102365705(LPCAT4) 106705844
CMK: 103176103(lpcat2) 103184820(lpcat1)
DME: Dmel_CG32699(LPCAT) Dmel_CG9655(nes)
DPE: 6602379
DSI: Dsimw501_GD12294(Dsim_GD12294) Dsimw501_GD16057(Dsim_GD16057)
PCF: 106784843
NVI: 100120270 100121021(nes)
API: 100169605
TUT: 107371126
CEL: CELE_R155.1(mboa-6)
CBR: CBG11740
BMY: Bm1_43565
TSP: Tsp_09580
EGL: EGR_10138
AQU: 105312343
ATH: AT1G12640(LPLAT1) AT1G63050(LPLAT2) AT1G80950 AT2G45670
LJA: Lj0g3v0057259.1(Lj0g3v0057259.1) Lj0g3v0333919.1(Lj0g3v0333919.1) Lj4g3v1335330.1(Lj4g3v1335330.1) Lj5g3v0090530.1(Lj5g3v0090530.1) Lj5g3v2297830.1(Lj5g3v2297830.1) Lj5g3v2297830.2(Lj5g3v2297830.2)
DOSA: Os02t0676000-01(Os02g0676000) Os05t0357800-01(Os05g0357800) Os06t0712300-01(Os06g0712300)
ATS: 109735877(LOC109735877) 109745146(LOC109745146) 109756914(LOC109756914) 109769853(LOC109769853)
ZMA: 100191712(TIDP3349) 100193648(cl15598_1c) 103627540 103637104
SCE: YOR175C(ALE1)
ERC: Ecym_3123
KMX: KLMA_40179(ALE1)
NCS: NCAS_0F00340(NCAS0F00340)
NDI: NDAI_0K02680(NDAI0K02680)
TPF: TPHA_0F02600(TPHA0F02600)
TBL: TBLA_0A09670(TBLA0A09670)
TDL: TDEL_0G04050(TDEL0G04050)
KAF: KAFR_0G02490(KAFR0G02490)
CAL: CAALFM_C207480WA(LPT1)
CAUR: QG37_00667
SLB: AWJ20_2560(ALE1)
NCR: NCU06194
NTE: NEUTE1DRAFT100500(NEUTE1DRAFT_100500)
MGR: MGG_08856
SSCK: SPSK_02327
MAW: MAC_01885
MAJ: MAA_00584
CMT: CCM_05827
BFU: BCIN_03g04280(Bcale1)
MBE: MBM_08219
ANI: AN6530.2
ANG: ANI_1_82134(An15g00450)
ABE: ARB_04117
TVE: TRV_03899
PTE: PTT_16886
CNE: CNA03380
CNB: CNBA3250
ABP: AGABI1DRAFT112247(AGABI1DRAFT_112247)
ABV: AGABI2DRAFT203434(AGABI2DRAFT_203434)
MGL: MGL_1418
DFA: DFA_08541
EHI: EHI_086180(94.t00024)
SMIN: v1.2.001286.t1(symbB.v1.2.001286.t1) v1.2.020999.t1(symbB.v1.2.020999.t1) v1.2.020999.t2(symbB.v1.2.020999.t2)
 » show all
Taxonomy
Reference
1  [PMID:6250446]
  Authors
Bell RM, Coleman RA.
  Title
Enzymes of glycerolipid synthesis in eukaryotes.
  Journal
Annu Rev Biochem 49:459-87 (1980)
DOI:10.1146/annurev.bi.49.070180.002331
Reference
2  [PMID:5661029]
  Authors
Hill EE, Lands WE.
  Title
Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine.
  Journal
Biochim Biophys Acta 152:645-8 (1968)
DOI:10.1016/0005-2760(68)90109-4
Reference
3  [PMID:598375]
  Authors
Miki Y, Hosaka K, Yamashita S, Handa H, Numa S.
  Title
Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes.
  Journal
Eur J Biochem 81:433-41 (1977)
DOI:10.1111/j.1432-1033.1977.tb11968.x
Reference
4  [PMID:6078124]
  Authors
van den Bosch H, van Golde LM, Eibl H, van Deenen LL.
  Title
The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes.
  Journal
Biochim Biophys Acta 144:613-23 (1967)
DOI:10.1016/0005-2760(67)90050-1
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.23
IUBMB Enzyme Nomenclature: 2.3.1.23
ExPASy - ENZYME nomenclature database: 2.3.1.23
BRENDA, the Enzyme Database: 2.3.1.23
CAS: 9027-64-9

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