KEGG   ENZYME: 2.3.1.67Help
Entry
EC 2.3.1.67                 Enzyme                                 

Name
1-alkylglycerophosphocholine O-acetyltransferase;
acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase;
acetyl-CoA:lyso-PAF acetyltransferase;
1-alkyl-2-lysolecithin acetyltransferase;
acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase;
blood platelet-activating factor acetyltransferase;
lyso-GPC:acetyl CoA acetyltransferase;
lyso-platelet activating factor:acetyl-CoA acetyltransferase;
lysoPAF:acetyl CoA acetyltransferase;
PAF acetyltransferase;
platelet-activating factor acylhydrolase;
platelet-activating factor-synthesizing enzyme;
1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase;
lyso-platelet-activating factor:acetyl-CoA acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine [RN:R03437]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
1-alkyl-sn-glycero-3-phosphocholine [CPD:C04317]
Product
CoA [CPD:C00010];
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine [CPD:C04598]
History
EC 2.3.1.67 created 1984
Pathway
ec00565  Ether lipid metabolism
ec01100  Metabolic pathways
Orthology
K13510  lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase
Genes
HSA: 54947(LPCAT2) 79888(LPCAT1)
PTR: 454095(LPCAT2) 461698(LPCAT1)
PPS: 100970278(LPCAT2) 100991866(LPCAT1)
GGO: 101125811(LPCAT1) 101148534(LPCAT2)
PON: 100435855(LPCAT1) 100449928(LPCAT2)
NLE: 100597870(CAPNS2) 100600471(LPCAT1)
MCC: 698605(LPCAT2) 710144(LPCAT1)
MCF: 102125601(LPCAT2) 102143549(LPCAT1)
CSAB: 103214933(LPCAT1) 103225898 103233009(LPCAT2)
RRO: 104668709(LPCAT1) 104671480(LPCAT2)
RBB: 108513712(LPCAT1) 108517697 108531262(LPCAT2)
CJC: 100389756(LPCAT2) 100393606(LPCAT1)
SBQ: 101032098(LPCAT1) 101042520(LPCAT2)
MMU: 210992(Lpcat1) 270084(Lpcat2) 70902(Lpcat2b)
RNO: 100359680(Lpcat2) 289439(Lpcat2b) 361467(Lpcat1)
NGI: 103731684(Lpcat2) 103749677(Lpcat1)
HGL: 101696607(Lpcat2) 101709594(Lpcat1)
CCAN: 109678676(Lpcat1) 109690724(Lpcat2) 109698670
OCU: 100341001(LPCAT2) 103346634(LPCAT1)
TUP: 102469903(LPCAT1) 102483475(LPCAT2) 102490658
CFA: 488066(LPCAT1) 611330(LPCAT2)
AML: 100464874(LPCAT2) 100480167(LPCAT1)
UMR: 103673788(LPCAT2) 103679260(LPCAT1)
ORO: 101362482(LPCAT1) 101377840(LPCAT2)
FCA: 101095078(LPCAT1) 101099093(LPCAT2)
PTG: 102959706(LPCAT2) 102971071(LPCAT1)
AJU: 106973282(LPCAT2) 106985126(LPCAT1)
BTA: 514646(LPCAT2) 788450(LPCAT1)
BOM: 102265598(LPCAT1) 102268140 102269060(LPCAT2)
BIU: 109556810 109572861(LPCAT2) 109574742(LPCAT1)
PHD: 102315143(LPCAT2) 102336330(LPCAT1)
CHX: 102178967 102184933(LPCAT2) 102186907(LPCAT1)
OAS: 101111661(LPCAT1) 101115816(LPCAT2) 101116368 101120465
SSC: 100217397(LPCAT1) 100517894(LPCAT2)
CFR: 102509280(LPCAT1) 102510009(LPCAT2) 102522183
CDK: 105085760 105097505(LPCAT2) 105102173(LPCAT1)
BACU: 103001888(LPCAT1) 103016463(LPCAT2)
LVE: 103071483(LPCAT2) 103079269 103087358(LPCAT1)
OOR: 101275731(LPCAT2) 101288915(LPCAT1) 101289522
ECB: 100060157 100061308(LPCAT2) 100071898(LPCAT1)
EPZ: 103553196(LPCAT2) 103553726 103567497(LPCAT1)
EAI: 106822468(LPCAT2) 106835899(LPCAT1) 106846498
MYB: 102244268(LPCAT1) 102245573 102259694(LPCAT2)
MYD: 102767459(LPCAT2) 102771533(LPCAT1) 102774257
HAI: 109371697(LPCAT1) 109373253 109395625(LPCAT2)
RSS: 109442046 109454189(LPCAT1) 109457117(LPCAT2) 109458550
PALE: 102884144(LPCAT2) 102894173 102894763(LPCAT1)
LAV: 100659656 100675219(LPCAT2) 100675458(LPCAT1)
MDO: 100014768(LPCAT2) 100015539(LPCAT1)
SHR: 100915216(LPCAT1) 100935270(LPCAT2)
OAA: 100074850(LPCAT1) 100077162(LPCAT2)
GGA: 415716(LPCAT2) 420974(LPCAT1)
MGP: 100546916(LPCAT2) 100547104(LPCAT1)
CJO: 107309445(LPCAT1) 107319184(LPCAT2)
APLA: 101791762(LPCAT1) 101802263(LPCAT2)
ACYG: 106043072 106045027(LPCAT1)
TGU: 100218938(LPCAT2) 100224379(LPCAT1)
GFR: 102037826(LPCAT2) 102044114(LPCAT1)
FAB: 101811593(LPCAT2) 101820727(LPCAT1)
PHI: 102106876(LPCAT2) 102107582(LPCAT1)
PMAJ: 107200159(LPCAT1) 107209745(LPCAT2)
CCAE: 111925329(LPCAT1) 111934581(LPCAT2)
CCW: 104685842(LPCAT1) 104687552(LPCAT2)
FPG: 101911522(LPCAT2) 101912706(LPCAT1)
FCH: 102050532(LPCAT2) 102059927(LPCAT1)
CLV: 102092846(LPCAT2) 102093144(LPCAT1)
EGZ: 104125183(LPCAT2) 104128509(LPCAT1)
AAM: 106483282(LPCAT2) 106492898(LPCAT1)
ASN: 102376020(LPCAT2) 102379638(LPCAT1)
AMJ: 102561877(LPCAT1) 102574060(LPCAT2)
PSS: 102450224(LPCAT1) 102462907(LPCAT2)
CMY: 102930396(LPCAT1) 102931433(LPCAT2)
CPIC: 101940623(LPCAT2) 101948289(LPCAT1)
ACS: 100557762(lpcat2) 100563014(lpcat1)
PVT: 110080886(LPCAT1) 110090095(LPCAT2)
GJA: 107108346(LPCAT2) 107123976(LPCAT1)
XLA: 108715344(lpcat2.S) 108720037(lpcat1.S)
XTR: 100124943(lpcat2) 100487143(lpcat1)
NPR: 108795131(LPCAT1) 108797887(LPCAT2) 108802237
DRE: 553683(lpcat2) 555969(lpcat1)
IPU: 108259642(lpcat2) 108272334(lpcat1) 108272386
AMEX: 103025479(lpcat1) 103025629
LCO: 104922776 104926947(lpcat2) 104940425(lpcat1) 109141540
OLA: 101159130(lpcat1) 101172965(lpcat2)
ELS: 105012400(lpcat1) 105016610 105023459(lpcat2)
SFM: 108919238 108928303(lpcat2) 108940486(lpcat1)
LCM: 102350271(LPCAT2) 102364428(LPCAT1) 106705844
CMK: 103176103(lpcat2) 103184820(lpcat1)
CIN: 100181981
SPU: 579107
APLC: 110980052
SKO: 102809674
DME: Dmel_CG32699(LPCAT)
DER: 6549790
DSI: Dsimw501_GD16057(Dsim_GD16057)
DWI: 6649046
MDE: 101890953
AAG: 5570702
AME: 550970
BIM: 100741953
BTER: 100652042
SOC: 105208206
AEC: 105145868
ACEP: 105619137
PBAR: 105432762
HST: 105189494
DQU: 106748929
CFO: 105249392
LHU: 105679165
PGC: 109855182
PCF: 106784843
NVI: 100120270
MDL: 103573992
TCA: 657636
DPA: 109534524
NVL: 108565066
BMOR: 101742486
PMAC: 106716089
PRAP: 111003489
HAW: 110375504
API: 100169605
CLEC: 106665896
ZNE: 110838403
FCD: 110855863
TSP: Tsp_09580
CRG: 105349224
MYI: 110443813
OBI: 106881720
SHX: MS3_09291
EGL: EGR_10138
HMG: 101239736
AQU: 105312343
CPAP: 110819447
LJA: Lj0g3v0057259.1(Lj0g3v0057259.1) Lj0g3v0333919.1(Lj0g3v0333919.1) Lj5g3v0090530.1(Lj5g3v0090530.1) Lj5g3v2297830.1(Lj5g3v2297830.1) Lj5g3v2297830.2(Lj5g3v2297830.2)
DOSA: Os05t0357800-01(Os05g0357800) Os06t0712300-01(Os06g0712300)
ATS: 109735877(LOC109735877) 109756914(LOC109756914) 109769853(LOC109769853)
ZMA: 100191712(TIDP3349) 100193648(cl15598_1c) 103637104
APRO: F751_2508
SMIN: v1.2.001286.t1(symbB.v1.2.001286.t1) v1.2.020999.t1(symbB.v1.2.020999.t1) v1.2.020999.t2(symbB.v1.2.020999.t2)
SPAR: SPRG_02060
 » show all
Taxonomy
Reference
1  [PMID:7430122]
  Authors
Wykle RL, Malone B, Snyder F.
  Title
Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid.
  Journal
J Biol Chem 255:10256-60 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.67
IUBMB Enzyme Nomenclature: 2.3.1.67
ExPASy - ENZYME nomenclature database: 2.3.1.67
BRENDA, the Enzyme Database: 2.3.1.67
CAS: 76773-96-1

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