KEGG   ENZYME: 2.7.1.159Help
Entry
EC 2.7.1.159                Enzyme                                 

Name
inositol-1,3,4-trisphosphate 5/6-kinase;
Ins(1,3,4)P3 5/6-kinase;
inositol trisphosphate 5/6-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
Reaction(IUBMB)
(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate [RN:R03428];
(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate [RN:R03429]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272];
1D-myo-inositol 1,3,4,6-tetrakisphosphate [CPD:C04477]
Comment
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2].
History
EC 2.7.1.159 created 2006
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
K01765  inositol-1,3,4-trisphosphate 5/6-kinase
Genes
HSA: 3705(ITPK1)
PTR: 453121(ITPK1)
PPS: 100980755(ITPK1)
GGO: 101134664(ITPK1)
PON: 100448118(ITPK1)
NLE: 100590495(ITPK1)
MCC: 698756(ITPK1)
MCF: 102119398(ITPK1)
CSAB: 103229579(ITPK1)
RRO: 104679048(ITPK1)
RBB: 108519106(ITPK1)
CJC: 100396941(ITPK1)
SBQ: 101039869(ITPK1)
MMU: 217837(Itpk1)
RNO: 500709(Itpk1)
CGE: 100768438(Itpk1)
NGI: 103724593(Itpk1)
HGL: 101700462(Itpk1)
CCAN: 109693572(Itpk1)
OCU: 100345790(ITPK1)
TUP: 102479480(ITPK1)
CFA: 490591(ITPK1)
AML: 100484787(ITPK1)
UMR: 103673773(ITPK1)
ORO: 101385854(ITPK1)
FCA: 101087672(ITPK1)
PTG: 102951160(ITPK1)
AJU: 106980827(ITPK1)
BTA: 518488(ITPK1)
BOM: 102279411(ITPK1)
BIU: 109575578(ITPK1)
PHD: 102333268(ITPK1)
CHX: 102183460(ITPK1)
OAS: 101115161(ITPK1)
SSC: 100152339(ITPK1)
CFR: 102508931(ITPK1)
CDK: 105095826(ITPK1)
BACU: 103011955(ITPK1)
LVE: 103084508(ITPK1)
OOR: 101270326(ITPK1)
ECB: 100063828(ITPK1)
EPZ: 103556533(ITPK1)
EAI: 106825383(ITPK1)
MYB: 102246792(ITPK1)
MYD: 102764458(ITPK1) 102773325
HAI: 109376793(ITPK1)
RSS: 109442311 109454623(ITPK1)
PALE: 102877958(ITPK1)
LAV: 100668527(ITPK1)
TMU: 101341573
MDO: 100014342(ITPK1)
SHR: 100924957(ITPK1) 111719345
OAA: 100079832(ITPK1)
GGA: 423421(ITPK1)
MGP: 100541150(ITPK1)
CJO: 107315185(ITPK1)
APLA: 101801656(ITPK1)
ACYG: 106033487(ITPK1)
TGU: 100222999(ITPK1)
GFR: 102034047(ITPK1)
FAB: 101819235(ITPK1)
PHI: 102106037(ITPK1)
PMAJ: 107205493(ITPK1)
CCAE: 111929864(ITPK1)
CCW: 104688688(ITPK1)
FPG: 101920131(ITPK1)
FCH: 102048369(ITPK1)
CLV: 102088692(ITPK1)
EGZ: 104135355(ITPK1)
AAM: 106483074(ITPK1)
ASN: 102373418(ITPK1) 112548809
AMJ: 102575334(ITPK1) 109280689
PSS: 102452019(ITPK1) 112546611
CMY: 102932685 102933310(ITPK1)
CPIC: 101948262(ITPK1) 101949054
ACS: 100566274(itpk1)
PVT: 110083634(ITPK1)
PBI: 103054635(ITPK1)
GJA: 107123858(ITPK1)
XLA: 108698651 108700483(itpk1.S) 379828(itpk1.L)
XTR: 100144987 549890(itpk1)
NPR: 108788675(ITPK1) 108804962
DRE: 100148744(itpk1b) 406290(itpk1a)
TRU: 101069194(itpk1) 101072928
NCC: 104941855(itpk1) 104945354
MZE: 101469029(itpk1) 101485309
OLA: 101157334(itpk1)
XMA: 102220593(itpk1)
PRET: 103458928(itpk1)
NFU: 107392041(itpk1)
KMR: 108237618(itpk1)
CSEM: 103377198(itpk1) 103378259
SDU: 111225701(itpk1) 111232797
HCQ: 109510866 109516026(itpk1)
BPEC: 110153603 110155270(itpk1)
MALB: 109955064(itpk1)
ELS: 105015588(itpk1) 105017670
SFM: 108919611(itpk1)
LCM: 102351625(ITPK1) 102366649
CMK: 103174155 103185398(itpk1)
CIN: 100181853
SPU: 580408
APLC: 110977634
SKO: 102806915
AME: 551726
BIM: 100740014
BTER: 100647743
SOC: 105195554
AEC: 105150186
ACEP: 105618310
PBAR: 105426206
HST: 105181094
DQU: 106743443
CFO: 105250081
LHU: 105673912
PGC: 109863770
PCF: 106784291
NVI: 100117094
MDL: 103578390
TCA: 660348
NVL: 108567762
BMOR: 101744563
PMAC: 106719950
PRAP: 110991381
HAW: 110378751
API: 100159102
DNX: 107163234
CLEC: 106662859
ZNE: 110837839
FCD: 110844108
CRG: 105337850
MYI: 110440574
OBI: 106874910
EPA: 110247170
LJA: Lj1g3v2095610.1(Lj1g3v2095610.1) Lj2g3v1495070.1(Lj2g3v1495070.1) Lj4g3v1107900.1(Lj4g3v1107900.1) Lj4g3v1477230.1(Lj4g3v1477230.1) Lj4g3v1882000.1(Lj4g3v1882000.1) Lj4g3v1882000.2(Lj4g3v1882000.2) Lj4g3v1882010.1(Lj4g3v1882010.1) Lj5g3v2063140.1(Lj5g3v2063140.1) Lj5g3v2063140.2(Lj5g3v2063140.2)
DOSA: Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os09t0518700-01(Os09g0518700) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
ATS: 109732807(LOC109732807) 109748791(LOC109748791) 109751093(LOC109751093) 109759444(LOC109759444) 109764293(LOC109764293) 109773428(LOC109773428)
DDI: DDB_G0269746(ITPK1)
DFA: DFA_02662(ITPK1)
EHI: EHI_042120(11.t00022) EHI_100310(151.t00008)
SPAR: SPRG_04523
 » show all
Taxonomy
Reference
1  [PMID:8662638]
  Authors
Wilson MP, Majerus PW.
  Title
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.
  Journal
J Biol Chem 271:11904-10 (1996)
DOI:10.1074/jbc.271.20.11904
  Sequence
[bta:518488]
Reference
2  [PMID:15531582]
  Authors
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW.
  Title
The pathway for the production of inositol hexakisphosphate in human cells.
  Journal
J Biol Chem 280:1911-20 (2005)
DOI:10.1074/jbc.M411528200
Reference
3  [PMID:15837423]
  Authors
Miller GJ, Wilson MP, Majerus PW, Hurley JH.
  Title
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
  Journal
Mol Cell 18:201-12 (2005)
DOI:10.1016/j.molcel.2005.03.016
  Sequence
[ehi:EHI_100310] [hsa:3705]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.159
IUBMB Enzyme Nomenclature: 2.7.1.159
ExPASy - ENZYME nomenclature database: 2.7.1.159
BRENDA, the Enzyme Database: 2.7.1.159
CAS: 288307-53-9

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