KEGG   ENZYME: 2.7.7.74Help
Entry
EC 2.7.7.74                 Enzyme                                 

Name
1L-myo-inositol 1-phosphate cytidylyltransferase;
CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
L-myo-inositol-1-phosphate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:1L-myo-inositol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol [RN:R09669]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
1L-myo-inositol 1-phosphate [CPD:C04006]
Product
diphosphate [CPD:C00013];
CDP-1L-myo-inositol [CPD:C19794]
Comment
In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
History
EC 2.7.7.74 created 2011
Pathway
ec00562  Inositol phosphate metabolism
Orthology
K07281  1L-myo-inositol 1-phosphate cytidylyltransferase
Genes
MTHD: A3224_07290
ENM: EBS_0412
NAR: Saro_0102
STAX: MC45_17790
GBE: GbCGDNIH1_0237
GDI: GDI0629(hasC)
GDJ: Gdia_1377
NTR: B0W44_00905
TMR: Tmar_0126
TPZ: Tph_c20790
RXY: Rxyl_1212
TTR: Tter_0472
RMR: Rmar_1196
AAE: aq_1367(spsI)
TTK: TST_0884
AFU: AF_0263
FPL: Ferp_0148
GAC: GACE_2065
GAH: GAH_01161
PHO: PH1219(PH1219)
PAB: PAB2433
PFU: PF1058
PFI: PFC_04525
PYN: PNA2_1704
PYS: Py04_1010
TKO: TK2279
TON: TON_1248
TGA: TGAM_1853
TSI: TSIB_1010
THE: GQS_09430
THA: TAM4_5
THM: CL1_1475
TLT: OCC_08385
THS: TES1_1181
TNU: BD01_1626
TEU: TEU_00190
PPAC: PAP_05835
ACJ: ACAM_0951
IAG: Igag_0487
HBU: Hbut_0150
TPE: Tpen_1250
KCR: Kcr_0184
BARC: AOA65_0707
 » show all
Taxonomy
Reference
1  [PMID:17526717]
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07
  Sequence
[aae:aq_1367] [afu:AF_0263] [pfu:PF1058][rxy:Rxyl_1212] [tko:TK2279]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.74
IUBMB Enzyme Nomenclature: 2.7.7.74
ExPASy - ENZYME nomenclature database: 2.7.7.74
BRENDA, the Enzyme Database: 2.7.7.74

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