KEGG   ENZYME: 3.1.3.78Help
Entry
EC 3.1.3.78                 Enzyme                                 

Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II;
type I PtdIns-4,5-P2 4-Ptase;
type II PtdIns-4,5-P2 4-Ptase;
IpgD;
PtdIns-4,5-P2 4-phosphatase type I;
PtdIns-4,5-P2 4-phosphatase type II;
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
type 1 4-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate [RN:R08981]
Reaction(KEGG)
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557];
phosphate [CPD:C00009]
Comment
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].
History
EC 3.1.3.78 created 2008
Orthology
K13084  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
K13085  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Genes
HSA: 55529(PIP4P2) 90809(PIP4P1)
PTR: 464281(PIP4P2) 465201(PIP4P1)
PPS: 100968374(TMEM55A) 100988983(TMEM55B)
GGO: 101129459(TMEM55A) 101132752(TMEM55B)
PON: 100451858(PIP4P2) 100454477(PIP4P1)
NLE: 100587627(TMEM55A) 100593745(TMEM55B)
MCC: 100428001(TMEM55B) 696779(TMEM55A)
MCF: 101866619(TMEM55B) 102115056(TMEM55A)
CSAB: 103231342 103231344 103237111(TMEM55A)
RRO: 104654642(TMEM55A) 104673120(TMEM55B)
RBB: 108527311(TMEM55B) 108528503(TMEM55A)
CJC: 100402264(TMEM55B) 100407390(TMEM55A)
SBQ: 101027468(TMEM55B) 101033445(TMEM55A)
MMU: 219024(Pip4p1) 72519(Pip4p2)
RNO: 362490(Tmem55a) 364298(Tmem55b)
CGE: 100757444(Tmem55b) 100767770(Tmem55a)
NGI: 103729539(Tmem55a) 103733665(Tmem55b)
HGL: 101709122(Tmem55b) 101718072(Tmem55a)
CCAN: 109690515(Tmem55a) 109692126(Tmem55b)
OCU: 100349176(TMEM55B) 100353159(TMEM55A)
TUP: 102475472(TMEM55B) 102487160 102499548(TMEM55A)
CFA: 477939(PIP4P2) 482559(PIP4P1)
AML: 100479476(TMEM55A) 100484149(TMEM55B)
UMR: 103656314(TMEM55B) 103661475(TMEM55A)
ORO: 101372920(TMEM55B) 101382006(TMEM55A)
FCA: 101080798(PIP4P1) 101088301(PIP4P2)
PTG: 102952164(TMEM55A) 102956222(TMEM55B)
AJU: 106971402(TMEM55B) 106984681(TMEM55A)
BTA: 615077(PIP4P1) 616641(PIP4P2)
BOM: 102268358(TMEM55B) 102277826(TMEM55A)
BIU: 109564878(TMEM55B) 109568638(TMEM55A)
PHD: 102333254(TMEM55A) 102337300(TMEM55B)
CHX: 102172557(TMEM55A) 102177240(TMEM55B)
OAS: 101111559(TMEM55A) 101117510(TMEM55B)
SSC: 100155939(TMEM55B) 100156639(TMEM55A)
CFR: 102505095(TMEM55A) 102507379(TMEM55B)
CDK: 105085724(TMEM55A) 105097644(TMEM55B)
BACU: 103007264(TMEM55A) 103012880(TMEM55B)
LVE: 103084248(TMEM55B) 103085248(TMEM55A)
OOR: 101273070(TMEM55A) 101273871(TMEM55B)
ECB: 100050790(PIP4P2) 100058648(PIP4P1)
EPZ: 103559551(TMEM55B) 103564881(TMEM55A)
EAI: 106833288(TMEM55B) 106838979(TMEM55A)
MYB: 102241548(TMEM55A) 102252193(TMEM55B)
MYD: 102754867(TMEM55B) 102773968(TMEM55A)
HAI: 109376449(TMEM55B)
RSS: 109438552(TMEM55B) 109444683(TMEM55A)
PALE: 102898229(PIP4P2) 102898278(PIP4P1)
LAV: 100660816(PIP4P1) 100664641(PIP4P2)
MDO: 100022045(TMEM55A) 100022893(TMEM55B)
SHR: 100916303(PIP4P2) 100924788(PIP4P1)
OAA: 100086066(TMEM55B) 100092908(TMEM55A)
GGA: 420221(TMEM55A)
MGP: 100542892(TMEM55A)
CJO: 107307004(TMEM55B) 107310378(TMEM55A)
APLA: 101802244(TMEM55A)
ACYG: 106030630(TMEM55A)
TGU: 100226950(TMEM55A)
GFR: 102040381(TMEM55A)
FAB: 101810791(TMEM55A)
PHI: 102099741(TMEM55A) 102101128(TMEM55B)
PMAJ: 107199089(TMEM55B) 107200089(TMEM55A)
CCW: 104692756(TMEM55A)
FPG: 101922579(TMEM55A)
FCH: 102055459(TMEM55A)
CLV: 102090519(TMEM55A)
EGZ: 104125810(TMEM55A)
AAM: 106496195(TMEM55A)
ASN: 102373932(PIP4P2) 102374449(PIP4P1)
AMJ: 102562249(TMEM55B) 102570595(TMEM55A)
PSS: 102452442 102457479(PIP4P2)
CMY: 102938814 102941676(TMEM55B)
CPIC: 101937348(TMEM55A) 101946066(TMEM55B)
ACS: 100556773(tmem55a) 100567084(tmem55b)
PVT: 110089558(TMEM55B) 110090207(TMEM55A)
PBI: 103047975(PIP4P1) 103054248(PIP4P2)
GJA: 107105993(TMEM55A) 107116165(TMEM55B)
XLA: 108695381(tmem55a.S) 108707045(tmem55b.S) 494834(tmem55b.L) 734343(tmem55a.L)
XTR: 100170610(tmem55b) 448483(tmem55a)
NPR: 108788678(TMEM55B) 108800143(TMEM55A)
DRE: 556136(pip4p1a) 566642(pip4p2)
IPU: 108273350(tmem55a) 108274853 108280404(tmem55b)
AMEX: 103033991(pip4p1) 103040016(pip4p2) 103040625
TRU: 101062738 101068075(tmem55a) 101075194(tmem55b)
LCO: 104924562(tmem55a) 104926554(tmem55b) 104936244 109140913
NCC: 104947052(tmem55a) 104948613(tmem55b)
MZE: 101466447 101468284(pip4p2) 101479252(pip4p1)
XMA: 102224770 102227240(pip4p2) 102234414(pip4p1)
PRET: 103472397(tmem55a) 103479490(tmem55b) 103480619
NFU: 107376897 107383456(tmem55b) 107394745(tmem55a)
CSEM: 103388924 103394417(tmem55a) 103396783(tmem55b)
HCQ: 109506970 109517989(tmem55a) 109529491(tmem55b)
BPEC: 110167447(tmem55a) 110170780 110175124(tmem55b)
ELS: 105006704(tmem55a) 105024555(tmem55b) 105030639
LCM: 102348811(TMEM55A) 102357306(TMEM55B)
CMK: 103191060(tmem55a)
CIN: 104266484
SPU: 588430
APLC: 110980124
SKO: 100368816
DME: Dmel_CG6707(CG6707)
DSI: Dsimw501_GD12881(Dsim_GD12881)
MDE: 101893850
AAG: 5574542
AME: 408301
BIM: 100749086
BTER: 100646549
SOC: 105200883
AEC: 105143615
ACEP: 105620209
PBAR: 105430510
HST: 105186717
CFO: 105255380
LHU: 105674095
PGC: 109854987
NVI: 100120829
TCA: 655804
DPA: 109534456
NVL: 108563960
BMOR: 101741980
PMAC: 106719144
PRAP: 110992215
PXY: 105393931
API: 100164628
DNX: 107167499
ZNE: 110834071
FCD: 110849352
TUT: 107359622
CEL: CELE_Y71H2AM.2(Y71H2AM.2)
CBR: CBG00490
BMY: Bm1_18965
CRG: 105338362
MYI: 110464767
OBI: 106874795
LAK: 106178509
SHX: MS3_09652
EPA: 110248578
ADF: 107342237
HMG: 100208471
AQU: 100632025
STY: STY1121(sigD)
STT: t1828(sigD)
STM: STM1091(sopB)
SEO: STM14_1237(sopB)
SEY: SL1344_1030(sopB)
SEJ: STMUK_1060(sopB)
SEB: STM474_1083(sopB)
SEF: UMN798_1133(sigD)
SETC: CFSAN001921_11720(sopB)
SENR: STMDT2_10271(sigD)
SEND: DT104_10731(sopB)
SENI: CY43_05575(sopB)
SEEN: SE451236_11305(sopB)
SPT: SPA1759(sigD)
SEK: SSPA1634
SEI: SPC_2659(sigD)
SEC: SCH_1043(sopB)
SHB: SU5_01724
SENH: CFSAN002069_03565(sopB)
SENS: Q786_04870(sopB)
SED: SeD_A1167
SEG: SG0980(sopB)
SEL: SPUL_1966(sopB)
SEGA: SPUCDC_1952(sopB)
SET: SEN0955(sopB)
SENA: AU38_04930(sopB)
SENO: AU37_04920(sopB)
SENV: AU39_04920(sopB)
SENQ: AU40_05535(sopB)
SENL: IY59_05020(sopB)
SEEC: CFSAN002050_11850(sopB)
SEEB: SEEB0189_014115(sopB)
SEEP: I137_08940(sopB)
SENE: IA1_05370(sopB)
SENC: SEET0819_12115(sopB)
SBG: SBG_0939(sopB)
SBZ: A464_1030
SBV: N643_04465(sopB)
SFL: CP0133(ipgD)
SFE: SFxv_4976(ipgD)
SSN: SSON_P095(ipgD)
SBC: SbBS512_A0166(ipgD)
SDY: SDY_P171(ipgD)
YAL: AT01_2850(sopB)
SGL: SG0550
SOD: Sant_3206(sigD) Sant_3209(sigD2)
PAY: PAU_01919
PSI: S70_12925
PSX: DR96_586(sopB)
VAN: VAA_02157
PPNO: DA70_11385
PPNM: LV28_19660
PSF: PSE_2750(ipgD)
PCU: pc1256(ipgD)
PNL: PNK_0614(ipgD)
 » show all
Taxonomy
Reference
1  [PMID:12356723]
  Authors
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
  Title
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
  Journal
EMBO J 21:5069-78 (2002)
  Sequence
[sfl:CP0133]
Reference
2  [PMID:16365287]
  Authors
Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
  Title
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
  Journal
Proc Natl Acad Sci U S A 102:18854-9 (2005)
DOI:10.1073/pnas.0509740102
  Sequence
[hsa:55529 90809]
Reference
3  [PMID:17940011]
  Authors
Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
  Title
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
  Journal
Proc Natl Acad Sci U S A 104:16834-9 (2007)
DOI:10.1073/pnas.0708189104
Reference
4  [PMID:17389247]
  Authors
Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S
  Title
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
  Journal
J Gen Physiol 129:267-83 (2007)
DOI:10.1085/jgp.200609656
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.78
IUBMB Enzyme Nomenclature: 3.1.3.78
ExPASy - ENZYME nomenclature database: 3.1.3.78
BRENDA, the Enzyme Database: 3.1.3.78

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