KEGG   ENZYME: 3.2.2.6Help
Entry
EC 3.2.2.6                  Enzyme                                 

Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;
NAD+ nucleosidase;
NADase (ambiguous);
DPNase (ambiguous);
DPN hydrolase (ambiguous);
NAD hydrolase (ambiguous);
nicotinamide adenine dinucleotide nucleosidase (ambiguous);
NAD glycohydrolase (misleading);
NAD nucleosidase (ambiguous);
nicotinamide adenine dinucleotide glycohydrolase (misleading);
CD38 (gene name);
BST1 (gene name)
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
NAD+ glycohydrolase (cyclic ADP-ribose-forming)
Reaction(IUBMB)
NAD+ + H2O = ADP-D-ribose + nicotinamide (overall reaction) [RN:R00102];
(1a) NAD+ = cyclic ADP-ribose + nicotinamide [RN:R10629];
(1b) cyclic ADP-ribose + H2O = ADP-D-ribose [RN:R10630]
Reaction(KEGG)
Substrate
NAD+ [CPD:C00003];
H2O [CPD:C00001];
cyclic ADP-ribose [CPD:C13050]
Product
ADP-D-ribose [CPD:C00301];
nicotinamide [CPD:C00153];
cyclic ADP-ribose [CPD:C13050]
Comment
This multiunctional enzyme acts on NAD+, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD+ glycohydrolase.
History
EC 3.2.2.6 created 1961, modified 2004, modified 2014, modified 2018
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K01242  ADP-ribosyl cyclase 1
K18152  ADP-ribosyl cyclase 2
Genes
HSA: 683(BST1) 952(CD38)
PTR: 461126(BST1) 745433(CD38)
PPS: 100972434(BST1) 100974952(CD38)
GGO: 101145401(BST1) 101149825(CD38)
PON: 100174150(BST1) 100457558(CD38)
NLE: 100606064(BST1) 100606960(CD38)
MCC: 714399(CD38) 722848(BST1)
MCF: 101926698(BST1) 102126394(CD38)
CSAB: 103246326(CD38) 103246328(BST1)
RRO: 104658167(BST1) 104658170(CD38)
RBB: 108531741(CD38) 108531746(BST1)
CJC: 100387937(CD38) 100402445(BST1)
SBQ: 101035567(BST1) 101036203(CD38)
MMU: 12182(Bst1) 12494(Cd38)
RNO: 25668(Cd38) 81506(Bst1)
CGE: 100773187(Cd38) 100773468(Bst1)
NGI: 103728882(Cd38) 103728884(Bst1)
HGL: 101713685(Bst1) 101720283(Cd38)
CCAN: 109691561(Cd38) 109691564(Bst1)
OCU: 100009409(CD38) 100351817(BST1)
TUP: 102468679(BST1) 102480083(CD38)
CFA: 403756(CD38) 488820(BST1)
AML: 100463977(BST1) 100481326(CD38)
UMR: 103658313(BST1) 103658362(CD38)
ORO: 101364829(CD38) 101365133(BST1)
FCA: 101101052(BST1) 101101308(CD38)
PTG: 102955186(CD38) 102962771(BST1)
AJU: 106975627(BST1) 106975653(CD38)
BTA: 327677(CD38) 616757(BST1)
BOM: 102271683(BST1) 102273331(CD38)
BIU: 109560088(BST1) 109560687(CD38)
PHD: 102322294(CD38) 102322993(BST1)
CHX: 102169848(BST1) 102172881(CD38)
OAS: 101116575(BST1) 105614340(CD38) 114115250 114115251 114115349
SSC: 100511702(CD38) 100625942(BST1)
CFR: 102508026(CD38) 102508256(BST1)
CDK: 105098338(BST1) 105098339(CD38)
BACU: 103000954(BST1) 103020545(CD38)
LVE: 103087769(CD38) 103088314(BST1)
OOR: 101284537(CD38) 101284786(BST1)
ECB: 100068959(CD38) 100068968(BST1)
EPZ: 103565758(BST1) 103565759(CD38)
EAI: 106827091(CD38) 106827092(BST1)
MYB: 102252244(CD38) 102252530(BST1)
MYD: 102759158(CD38) 102770056(BST1)
HAI: 109372167(CD38) 109372831(BST1)
RSS: 109435264(CD38) 109452142(BST1)
PALE: 102884937(BST1) 102889755(CD38)
LAV: 100659997(BST1) 100660287(CD38)
TMU: 101346112 101346368
MDO: 100015733(BST1) 103094598(CD38)
SHR: 100915627(BST1) 105751033(CD38)
PCW: 110212831(BST1) 110212844(CD38)
OAA: 100074315(CD38) 100079912(BST1)
GGA: 422827(CD38) 422828(BST1)
MGP: 100546297(BST1) 100548136(CD38)
CJO: 107313950(BST1) 107313951(CD38)
APLA: 101799363(BST1)
ACYG: 106033418(CD38) 106035386(BST1)
TGU: 100224783(BST1) 101232999(CD38)
SCAN: 103824309(BST1) 103824319
GFR: 102032481(BST1) 102032646(CD38)
FAB: 101808664(BST1) 101813225(CD38)
PHI: 102100836(CD38) 102101014(BST1)
PMAJ: 107203272 107203546
CCAE: 111928170 111928172
CCW: 104690721 104690901(CD38)
FPG: 101912278(CD38) 101917967(BST1)
FCH: 102048375 102048871
CLV: 102089855(BST1)
EGZ: 104134476(BST1) 104134477(CD38)
NNI: 104010763(CD38) 104010764(BST1)
ACUN: 113479380 113479383(BST1)
AAM: 106498697 106498751
ASN: 102376962(BST1)
AMJ: 102559494(BST1)
PSS: 102444728(BST1) 102444963(CD38)
CMY: 102933631(BST1) 102933862(CD38)
CPIC: 101935271(BST1) 101935553(CD38)
ACS: 100566030(cd38)
PVT: 110085956(CD38)
PBI: 103059310
PMUR: 107292463
GJA: 107120012(CD38)
XLA: 100036901(cd38.L) 100873156(cd38b) 101027297(bst1.L)
XTR: 101733556(bst1) 496666(cd38)
NPR: 108799310(BST1) 108799313
DRE: 101886891
SRX: 107750973(cd38)
SANH: 107693813
SGH: 107568972
CCAR: 109104929(cd38)
IPU: 108256685 108259605
PHYP: 113532851 113546708
AMEX: 103029242
EEE: 113582404 113582405
TRU: 101065178 101069493 101074837 101075059 105418446 105418447
TNG: GSTEN00025533G001 GSTEN00025534G001
LCO: 104933795 104933796 104933803
NCC: 104942392 104946571 104946574
MZE: 101478770 101479062 101479335
OLA: 101168159 101168658 101168676
XMA: 102227962 102228215 106699822
PRET: 103456798 103456800 103456801
NFU: 107382594 107382595
KMR: 108230245 108230355 108230372
CSEM: 103377367 103377368
LCF: 108900033 108900035
SDU: 111224346 111224354
HCQ: 109517521
BPEC: 110165536 110165581
SASA: 106590199 106590200
OTW: 112227553 112227908 112245217 112245218 112245308 112245312
SALP: 111953730
ELS: 105031580
SFM: 108922735 108922775
PKI: 111850018 111850115
LCM: 102348898 102364780 106706579 106707079
CMK: 103175800
SPU: 100126187(arc3) 100859964(arc4) 576085(arc2) 580868(arc1)
APLC: 110977913 110981710
SKO: 100370260
HRO: HELRODRAFT_179637 HELRODRAFT_193621
LGI: LOTGIDRAFT_150043 LOTGIDRAFT_218611
PCAN: 112555169 112555726 112555871
CRG: 105319809
MYI: 110451407 110458378
LAK: 106153853 106155009 106155798 106159481 106159482 106169313 106180219 106180220
SMM: Smp_025830
OVI: T265_08021 T265_08022
NVE: NEMVE_v1g217601
EPA: 110246357 110251379
ADF: 107339424 107340996
PDAM: 113669069 113675387
SPIS: 111329655
HMG: 100199121 100199929 100211840
TAD: TRIADDRAFT_19184 TRIADDRAFT_36890 TRIADDRAFT_51409
AQU: 105312071 105312710
 » show all
Taxonomy
Reference
1  [PMID:2613697]
  Authors
Imai T
  Title
Purification and characterization of a pyridine nucleotide glycohydrolase from rabbit spleen.
  Journal
J Biochem 106:928-37 (1989)
Reference
2  [PMID:8235624]
  Authors
Howard M, Grimaldi JC, Bazan JF, Lund FE, Santos-Argumedo L, Parkhouse RM, Walseth TF, Lee HC
  Title
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.
  Journal
Science 262:1056-9 (1993)
DOI:10.1126/science.8235624
Reference
3  [PMID:8253715]
  Authors
Takasawa S, Tohgo A, Noguchi N, Koguma T, Nata K, Sugimoto T, Yonekura H, Okamoto H
  Title
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.
  Journal
J Biol Chem 268:26052-4 (1993)
  Sequence
[hsa:952]
Reference
4  [PMID:7961800]
  Authors
Tohgo A, Takasawa S, Noguchi N, Koguma T, Nata K, Sugimoto T, Furuya Y, Yonekura H, Okamoto H
  Title
Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.
  Journal
J Biol Chem 269:28555-7 (1994)
Reference
5  [PMID:7663169]
  Authors
Fryxell KB, O'Donoghue K, Graeff RM, Lee HC, Branton WD
  Title
Functional expression of soluble forms of human CD38 in Escherichia coli and Pichia pastoris.
  Journal
Protein Expr Purif 6:329-36 (1995)
DOI:10.1006/prep.1995.1043
Reference
6  [PMID:11866528]
  Authors
Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K.
  Title
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.
  Journal
J Mol Biol 316:711-23 (2002)
DOI:10.1006/jmbi.2001.5386
  Sequence
[hsa:683]
Reference
7  [PMID:16154090]
  Authors
Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q
  Title
Crystal structure of human CD38 extracellular domain.
  Journal
Structure 13:1331-9 (2005)
DOI:10.1016/j.str.2005.05.012
  Sequence
[hsa:952]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.6
IUBMB Enzyme Nomenclature: 3.2.2.6
ExPASy - ENZYME nomenclature database: 3.2.2.6
BRENDA, the Enzyme Database: 3.2.2.6
CAS: 9032-65-9

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (7)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (340)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (279)   
   KEGG MGENES (1)   
   RefGene (58)   
Protein sequence (37)   
   UniProt (10)   
   SWISS-PROT (10)   
   RefSeq(pep) (9)   
   PDBSTR (8)   
DNA sequence (9)   
   RefSeq(nuc) (9)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   InterPro (2)   
All databases (408)   

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