Entry |
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Name |
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;
NAD+ nucleosidase;
NADase (ambiguous);
DPNase (ambiguous);
DPN hydrolase (ambiguous);
NAD hydrolase (ambiguous);
nicotinamide adenine dinucleotide nucleosidase (ambiguous);
NAD glycohydrolase (misleading);
NAD nucleosidase (ambiguous);
nicotinamide adenine dinucleotide glycohydrolase (misleading);
CD38 (gene name);
BST1 (gene name)
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Class |
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
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Sysname |
NAD+ glycohydrolase (cyclic ADP-ribose-forming)
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Reaction(IUBMB) |
NAD+ + H2O = ADP-D-ribose + nicotinamide (overall reaction) [RN: R00102];
(1a) NAD+ = cyclic ADP-ribose + nicotinamide [RN: R10629];
(1b) cyclic ADP-ribose + H2O = ADP-D-ribose [RN: R10630]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
This multiunctional enzyme acts on NAD+, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD+ glycohydrolase.
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History |
EC 3.2.2.6 created 1961, modified 2004, modified 2014, modified 2018
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Pathway |
ec00760 | Nicotinate and nicotinamide metabolism |
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Imai T |
Title |
Purification and characterization of a pyridine nucleotide glycohydrolase from rabbit spleen. |
Journal |
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Reference |
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Authors |
Howard M, Grimaldi JC, Bazan JF, Lund FE, Santos-Argumedo L, Parkhouse RM, Walseth TF, Lee HC |
Title |
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. |
Journal |
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Reference |
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Authors |
Takasawa S, Tohgo A, Noguchi N, Koguma T, Nata K, Sugimoto T, Yonekura H, Okamoto H |
Title |
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. |
Journal |
J Biol Chem 268:26052-4 (1993) |
Sequence |
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Reference |
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Authors |
Tohgo A, Takasawa S, Noguchi N, Koguma T, Nata K, Sugimoto T, Furuya Y, Yonekura H, Okamoto H |
Title |
Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38. |
Journal |
J Biol Chem 269:28555-7 (1994) |
Reference |
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Authors |
Fryxell KB, O'Donoghue K, Graeff RM, Lee HC, Branton WD |
Title |
Functional expression of soluble forms of human CD38 in Escherichia coli and Pichia pastoris. |
Journal |
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Reference |
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Authors |
Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K. |
Title |
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. |
Journal |
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Sequence |
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Reference |
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Authors |
Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q |
Title |
Crystal structure of human CD38 extracellular domain. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 3.2.2.6 |
ExPASy - ENZYME nomenclature database: | 3.2.2.6 |
BRENDA, the Enzyme Database: | 3.2.2.6 |
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