KEGG   ENZYME: 4.2.3.74Help
Entry
EC 4.2.3.74                 Enzyme                                 

Name
presilphiperfolanol synthase;
BcBOT2, CND15
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphohydrolase (presilphiperfolan-8beta-ol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = presilphiperfolan-8beta-ol + diphosphate [RN:R09630]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
presilphiperfolan-8beta-ol [CPD:C19756];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Presilphiperfolan-8beta-ol is the precursor of botrydial, a phytotoxic sesquiterpene metabolite secreted by the fungus Botryotinia fuckeliana (Botrytis cinerea), the causal agent of gray mold disease in plants.
History
EC 4.2.3.74 created 2011
Orthology
K22056  presilphiperfolanol synthase
Reference
1  [PMID:19035644]
  Authors
Pinedo C, Wang CM, Pradier JM, Dalmais B, Choquer M, Le Pecheur P, Morgant G, Collado IG, Cane DE, Viaud M
  Title
Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea.
  Journal
ACS Chem Biol 3:791-801 (2008)
DOI:10.1021/cb800225v
  Sequence
Reference
2  [PMID:19476353]
  Authors
Wang CM, Hopson R, Lin X, Cane DE
  Title
Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8beta-ol.
  Journal
J Am Chem Soc 131:8360-1 (2009)
DOI:10.1021/ja9021649
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.74
IUBMB Enzyme Nomenclature: 4.2.3.74
ExPASy - ENZYME nomenclature database: 4.2.3.74
BRENDA, the Enzyme Database: 4.2.3.74

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