KEGG   PATHWAY: hsa00190
Entry
hsa00190                    Pathway                                
Name
Oxidative phosphorylation - Homo sapiens (human)
Class
Metabolism; Energy metabolism
Pathway map
hsa00190  Oxidative phosphorylation
hsa00190

Module
hsa_M00142  NADH:ubiquinone oxidoreductase, mitochondria [PATH:hsa00190]
hsa_M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:hsa00190]
hsa_M00146  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex [PATH:hsa00190]
hsa_M00147  NADH dehydrogenase (ubiquinone) 1 beta subcomplex [PATH:hsa00190]
hsa_M00148  Succinate dehydrogenase (ubiquinone) [PATH:hsa00190]
hsa_M00151  Cytochrome bc1 complex respiratory unit [PATH:hsa00190]
hsa_M00152  Cytochrome bc1 complex [PATH:hsa00190]
hsa_M00154  Cytochrome c oxidase [PATH:hsa00190]
hsa_M00158  F-type ATPase, eukaryotes [PATH:hsa00190]
hsa_M00160  V-type ATPase, eukaryotes [PATH:hsa00190]
Drug
D07917  Esomeprazole (INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
100532726  NDUFC2-KCTD14; NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2 isoform 2 [KO:K03968]
10063  COX17; cytochrome c oxidase copper chaperone isoform b [KO:K02260]
101927180  ATP6V1FP2; V-type proton ATPase subunit F-like [KO:K02151]
10312  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform a [KO:K02154]
10476  ATP5PD; ATP synthase peripheral stalk subunit d, mitochondrial isoform a [KO:K02138]
10632  ATP5MG; ATP synthase F(0) complex subunit g, mitochondrial [KO:K02140]
107984365  [KO:K03948]
10975  UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420]
124901481  [KO:K02130]
125965  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
126328  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform 1 [KO:K03956]
127124  ATP6V1G3; V-type proton ATPase subunit G 3 isoform a [KO:K02152]
1327  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1 precursor [KO:K02263]
1329  COX5B; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
1337  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
1339  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266]
1340  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
1345  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
1346  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial precursor [KO:K02270]
1347  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
1349  COX7B; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271]
1350  COX7C; cytochrome c oxidase subunit 7C, mitochondrial precursor [KO:K02272]
1351  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
1352  COX10; protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
1353  COX11; cytochrome c oxidase assembly protein COX11, mitochondrial isoform 1 [KO:K02258]
1355  COX15; heme A synthase COX15 isoform 1 [KO:K02259] [EC:1.17.99.9]
1537  CYC1; cytochrome c1, heme protein, mitochondrial precursor [KO:K00413]
155066  ATP6V0E2; V-type proton ATPase subunit e 2 isoform 1 [KO:K02153]
170712  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial precursor [KO:K02271]
23545  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
245972  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
245973  ATP6V1C2; V-type proton ATPase subunit C 2 isoform a [KO:K02148]
267020  ATP5MGL; ATP synthase subunit g 2, mitochondrial [KO:K02140]
27068  PPA2; inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor [KO:K01507] [EC:3.6.1.1]
27089  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
29796  UQCR10; cytochrome b-c1 complex subunit 9 isoform a [KO:K00419]
341947  COX8C; cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
374291  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 1 [KO:K03940] [EC:7.1.1.2]
440567  UQCRHL; cytochrome b-c1 complex subunit 6-like, mitochondrial [KO:K00416]
4508  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
4509  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
4512  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4513  COX2; cytochrome c oxidase subunit II [KO:K02261]
4514  COX3; cytochrome c oxidase subunit III [KO:K02262]
4519  CYTB; cytochrome b [KO:K00412]
4535  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4536  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4537  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4538  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4539  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4540  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4541  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
4694  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
4695  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform 1 [KO:K03946]
4696  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
4697  COXFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
4698  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 1 [KO:K03949]
4700  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
4701  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
4702  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform 1 [KO:K03952]
4704  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor [KO:K03953]
4705  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform 1 precursor [KO:K03954]
4706  NDUFAB1; acyl carrier protein, mitochondrial precursor [KO:K03955]
4707  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
4708  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor [KO:K03958]
4709  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
4710  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 1 [KO:K03960]
4711  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 1 precursor [KO:K03961]
4712  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform 1 [KO:K03962]
4713  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
4714  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 1 precursor [KO:K03964]
4715  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1 [KO:K03965]
4716  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
4717  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor [KO:K03967]
4718  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform 1 [KO:K03968]
4719  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform 1 precursor [KO:K03934] [EC:7.1.1.2]
4720  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform 1 precursor [KO:K03935] [EC:7.1.1.2]
4722  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor [KO:K03936] [EC:7.1.1.2]
4723  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform 1 precursor [KO:K03942] [EC:7.1.1.2]
4724  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform 1 precursor [KO:K03937]
4725  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
4726  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor [KO:K03939]
4728  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial precursor [KO:K03941] [EC:7.1.1.2]
4729  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
4731  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform b precursor [KO:K03944]
479  ATP12A; potassium-transporting ATPase alpha chain 2 isoform 2 [KO:K01544] [EC:7.2.2.19]
495  ATP4A; potassium-transporting ATPase alpha chain 1 [KO:K01542] [EC:7.2.2.19]
496  ATP4B; potassium-transporting ATPase subunit beta [KO:K01543] [EC:7.2.2.19]
498  ATP5F1A; ATP synthase F(1) complex subunit alpha, mitochondrial isoform a precursor [KO:K02132]
506  ATP5F1B; ATP synthase F(1) complex subunit beta, mitochondrial precursor [KO:K02133] [EC:7.1.2.2]
50617  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
509  ATP5F1C; ATP synthase F(1) complex subunit gamma, mitochondrial isoform L (liver) precursor [KO:K02136]
51079  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
513  ATP5F1D; ATP synthase F(1) complex subunit delta, mitochondrial precursor [KO:K02134]
51382  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
514  ATP5F1E; ATP synthase F(1) complex subunit epsilon, mitochondrial [KO:K02135]
515  ATP5PB; ATP synthase peripheral stalk subunit b, mitochondrial precursor [KO:K02127]
516  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial precursor [KO:K02128]
51606  ATP6V1H; V-type proton ATPase subunit H isoform 1 [KO:K02144]
517  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform c precursor [KO:K02128]
518  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor [KO:K02128]
521  ATP5ME; ATP synthase F(0) complex subunit e, mitochondrial [KO:K02129]
522  ATP5PF; ATP synthase peripheral stalk subunit F6, mitochondrial isoform a precursor [KO:K02131]
523  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
525  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
526  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
527  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
528  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
529  ATP6V1E1; V-type proton ATPase subunit E 1 isoform a [KO:K02150]
533  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1 [KO:K03661]
534  ATP6V1G2; V-type proton ATPase subunit G 2 isoform a [KO:K02152]
535  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform 1 [KO:K02154]
537  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
539  ATP5PO; ATP synthase peripheral stalk subunit OSCP, mitochondrial precursor [KO:K02137]
54205  CYCS; cytochrome c [KO:K08738]
54539  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform 2 [KO:K11351]
5464  PPA1; inorganic pyrophosphatase [KO:K01507] [EC:3.6.1.1]
55967  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform a [KO:K11352]
56901  COXFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
6389  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 1 [KO:K00234] [EC:1.3.5.1]
6390  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform 1 precursor [KO:K00235] [EC:1.3.5.1]
6391  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 1 precursor [KO:K00236]
6392  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform a precursor [KO:K00237]
64077  LHPP; phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 1 [KO:K11725] [EC:3.6.1.1 3.1.3.-]
7381  UQCRB; cytochrome b-c1 complex subunit 7 isoform 1 [KO:K00417]
7384  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial precursor [KO:K00414]
7385  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial precursor [KO:K00415]
7386  UQCRFS1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
7388  UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor [KO:K00416]
84701  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
8992  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
90423  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
9114  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
9167  COX7A2L; cytochrome c oxidase subunit 7A2-like, mitochondrial isoform a [KO:K02270]
9296  ATP6V1F; V-type proton ATPase subunit F isoform 1 [KO:K02151]
9377  COX5A; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
9550  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
9551  ATP5MF; ATP synthase F(0) complex subunit f, mitochondrial isoform 2a [KO:K02130]
Compound
C00001  H2O
C00002  ATP
C00003  NAD+
C00004  NADH
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00042  Succinate
C00080  H+
C00122  Fumarate
C00536  Triphosphate
Reference
PMID:16469879
  Authors
Sazanov LA, Hinchliffe P.
  Title
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.
  Journal
Science 311:1430-6 (2006)
DOI:10.1126/science.1123809
Reference
PMID:16584177
  Authors
Hinchliffe P, Carroll J, Sazanov LA.
  Title
Identification of a novel subunit of respiratory complex I from Thermus thermophilus.
  Journal
Biochemistry 45:4413-20 (2006)
DOI:10.1021/bi0600998
KO pathway
ko00190   

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