KEGG   PATHWAY: hsa03460
Entry
hsa03460                    Pathway                                
Name
Fanconi anemia pathway - Homo sapiens (human)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
hsa03460  Fanconi anemia pathway
hsa03460

Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01447  Double Holliday junction dissolution
N01448  Double Holliday junction resolution
N01464  Fanconi anemia pathway
N01465  Lesion bypass by TLS and DSB formation
N01466  Homologous recombination in ICLR
N01539  RAD51 -dsDNA destabilization
Drug
D12558  Emzadirib (USAN)
Other DBs
GO: 0043240
Organism
Homo sapiens (human) [GN:hsa]
Gene
100526739  CENPS-CORT; CENPS-CORT readthrough [KO:K11511]
11201  POLI; DNA polymerase iota [KO:K03510] [EC:2.7.7.7]
116028  RMI2; RecQ mediated genome instability 2 [KO:K15365]
130134321  [KO:K15078] [EC:3.6.1.-]
146956  EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
197342  EME2; essential meiotic structure-specific endonuclease subunit 2 [KO:K10883]
201254  CENPX; centromere protein X [KO:K15360]
2067  ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit [KO:K10849]
2072  ERCC4; ERCC excision repair 4, endonuclease catalytic subunit [KO:K10848] [EC:3.1.-.-]
2175  FANCA; FA complementation group A [KO:K10888]
2176  FANCC; FA complementation group C [KO:K10890]
2177  FANCD2; FA complementation group D2 [KO:K10891]
2178  FANCE; FA complementation group E [KO:K10892]
2187  FANCB; FA complementation group B [KO:K10889]
2188  FANCF; FA complementation group F [KO:K10893]
2189  FANCG; FA complementation group G [KO:K10894]
22909  FAN1; FANCD2 and FANCI associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
29089  UBE2T; ubiquitin conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
29935  RPA4; replication protein A4 [KO:K10741]
3280  HES1; hes family bHLH transcription factor 1 [KO:K06054]
353497  POLN; DNA polymerase nu [KO:K16618] [EC:2.7.7.7]
378708  CENPS; centromere protein S [KO:K11511]
4292  MLH1; mutL homolog 1 [KO:K08734]
51426  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
51455  REV1; REV1 DNA directed polymerase [KO:K03515] [EC:2.7.7.-]
5395  PMS2; PMS1 homolog 2, mismatch repair system component [KO:K10858]
5429  POLH; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
545  ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
548593  SLX1A; SLX1 homolog A, structure-specific endonuclease subunit [KO:K15078] [EC:3.6.1.-]
55120  FANCL; FA complementation group L [KO:K10606] [EC:2.3.2.27]
55215  FANCI; FA complementation group I [KO:K10895]
57599  WDR48; WD repeat domain 48 [KO:K15361]
57697  FANCM; FA complementation group M [KO:K10896]
5888  RAD51; RAD51 recombinase [KO:K04482]
5889  RAD51C; RAD51 paralog C [KO:K10870]
5980  REV3L; REV3 like, DNA directed polymerase zeta catalytic subunit [KO:K02350] [EC:2.7.7.7]
6117  RPA1; replication protein A1 [KO:K07466]
6118  RPA2; replication protein A2 [KO:K10739]
6119  RPA3; replication protein A3 [KO:K10740]
641  BLM; BLM RecQ like helicase [KO:K10901] [EC:5.6.2.4]
672  BRCA1; BRCA1 DNA repair associated [KO:K10605] [EC:2.3.2.27]
675  BRCA2; BRCA2 DNA repair associated [KO:K08775]
7156  TOP3A; DNA topoisomerase III alpha [KO:K03165] [EC:5.6.2.1]
7398  USP1; ubiquitin specific peptidase 1 [KO:K11832] [EC:3.4.19.12]
79008  SLX1B; SLX1 homolog B, structure-specific endonuclease subunit [KO:K15078] [EC:3.6.1.-]
79728  PALB2; partner and localizer of BRCA2 [KO:K10897]
80010  RMI1; RecQ mediated genome instability 1 [KO:K10990]
80198  MUS81; MUS81 structure-specific endonuclease subunit [KO:K08991] [EC:3.1.22.-]
80233  FAAP100; FA core complex associated protein 100 [KO:K10993]
83990  BRIP1; BRCA1 interacting helicase 1 [KO:K15362] [EC:5.6.2.3]
84126  ATRIP; ATR interacting protein [KO:K10905]
84464  SLX4; SLX4 structure-specific endonuclease subunit [KO:K10484]
8940  TOP3B; DNA topoisomerase III beta [KO:K03165] [EC:5.6.2.1]
91442  FAAP24; FA core complex associated protein 24 [KO:K10898]
9894  TELO2; telomere maintenance 2 [KO:K11137]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
hsa03430  Mismatch repair
hsa03440  Homologous recombination
KO pathway
ko03460   

  All links  
No link information was found.
KEGG   PATHWAY: hsa03460
Entry
hsa03460                    Pathway                                
Name
Fanconi anemia pathway - Homo sapiens (human)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
hsa03460  Fanconi anemia pathway
hsa03460

Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01447  Double Holliday junction dissolution
N01448  Double Holliday junction resolution
N01464  Fanconi anemia pathway
N01465  Lesion bypass by TLS and DSB formation
N01466  Homologous recombination in ICLR
N01539  RAD51 -dsDNA destabilization
Drug
D12558  Emzadirib (USAN)
Other DBs
GO: 0043240
Organism
Homo sapiens (human) [GN:hsa]
Gene
100526739  CENPS-CORT; CENPS-CORT readthrough [KO:K11511]
11201  POLI; DNA polymerase iota [KO:K03510] [EC:2.7.7.7]
116028  RMI2; RecQ mediated genome instability 2 [KO:K15365]
130134321  [KO:K15078] [EC:3.6.1.-]
146956  EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
197342  EME2; essential meiotic structure-specific endonuclease subunit 2 [KO:K10883]
201254  CENPX; centromere protein X [KO:K15360]
2067  ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit [KO:K10849]
2072  ERCC4; ERCC excision repair 4, endonuclease catalytic subunit [KO:K10848] [EC:3.1.-.-]
2175  FANCA; FA complementation group A [KO:K10888]
2176  FANCC; FA complementation group C [KO:K10890]
2177  FANCD2; FA complementation group D2 [KO:K10891]
2178  FANCE; FA complementation group E [KO:K10892]
2187  FANCB; FA complementation group B [KO:K10889]
2188  FANCF; FA complementation group F [KO:K10893]
2189  FANCG; FA complementation group G [KO:K10894]
22909  FAN1; FANCD2 and FANCI associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
29089  UBE2T; ubiquitin conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
29935  RPA4; replication protein A4 [KO:K10741]
3280  HES1; hes family bHLH transcription factor 1 [KO:K06054]
353497  POLN; DNA polymerase nu [KO:K16618] [EC:2.7.7.7]
378708  CENPS; centromere protein S [KO:K11511]
4292  MLH1; mutL homolog 1 [KO:K08734]
51426  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
51455  REV1; REV1 DNA directed polymerase [KO:K03515] [EC:2.7.7.-]
5395  PMS2; PMS1 homolog 2, mismatch repair system component [KO:K10858]
5429  POLH; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
545  ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
548593  SLX1A; SLX1 homolog A, structure-specific endonuclease subunit [KO:K15078] [EC:3.6.1.-]
55120  FANCL; FA complementation group L [KO:K10606] [EC:2.3.2.27]
55215  FANCI; FA complementation group I [KO:K10895]
57599  WDR48; WD repeat domain 48 [KO:K15361]
57697  FANCM; FA complementation group M [KO:K10896]
5888  RAD51; RAD51 recombinase [KO:K04482]
5889  RAD51C; RAD51 paralog C [KO:K10870]
5980  REV3L; REV3 like, DNA directed polymerase zeta catalytic subunit [KO:K02350] [EC:2.7.7.7]
6117  RPA1; replication protein A1 [KO:K07466]
6118  RPA2; replication protein A2 [KO:K10739]
6119  RPA3; replication protein A3 [KO:K10740]
641  BLM; BLM RecQ like helicase [KO:K10901] [EC:5.6.2.4]
672  BRCA1; BRCA1 DNA repair associated [KO:K10605] [EC:2.3.2.27]
675  BRCA2; BRCA2 DNA repair associated [KO:K08775]
7156  TOP3A; DNA topoisomerase III alpha [KO:K03165] [EC:5.6.2.1]
7398  USP1; ubiquitin specific peptidase 1 [KO:K11832] [EC:3.4.19.12]
79008  SLX1B; SLX1 homolog B, structure-specific endonuclease subunit [KO:K15078] [EC:3.6.1.-]
79728  PALB2; partner and localizer of BRCA2 [KO:K10897]
80010  RMI1; RecQ mediated genome instability 1 [KO:K10990]
80198  MUS81; MUS81 structure-specific endonuclease subunit [KO:K08991] [EC:3.1.22.-]
80233  FAAP100; FA core complex associated protein 100 [KO:K10993]
83990  BRIP1; BRCA1 interacting helicase 1 [KO:K15362] [EC:5.6.2.3]
84126  ATRIP; ATR interacting protein [KO:K10905]
84464  SLX4; SLX4 structure-specific endonuclease subunit [KO:K10484]
8940  TOP3B; DNA topoisomerase III beta [KO:K03165] [EC:5.6.2.1]
91442  FAAP24; FA core complex associated protein 24 [KO:K10898]
9894  TELO2; telomere maintenance 2 [KO:K11137]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
hsa03430  Mismatch repair
hsa03440  Homologous recombination
KO pathway
ko03460   

  All links  
No link information was found.
DBGET integrated database retrieval system