KEGG   Homo sapiens (human): 10188
Entry
10188             CDS       T01001                                 
Symbol
TNK2, ACK, ACK-1, ACK1, p21cdc42Hs
Name
(RefSeq) tyrosine kinase non receptor 2
  KO
K08886  activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    10188 (TNK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     10188 (TNK2)
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     10188 (TNK2)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  ACK family
   10188 (TNK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase GTPase_binding SAM_TNK Inhibitor_Mig-6 SH3_9 UBA_4 Kinase-like SH3_1 SH3_2 HTH_8
Other DBs
NCBI-GeneID: 10188
NCBI-ProteinID: NP_005772
OMIM: 606994
HGNC: 19297
Ensembl: ENSG00000061938
UniProt: Q07912 B3KXJ4
Structure
Position
3:complement(195863364..195908551)
AA seq 1038 aa
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP
GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP
AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA
PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA
GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP
APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD
KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL
EQAGCHLLGSWGPAHHKR
NT seq 3117 nt   +upstreamnt  +downstreamnt
atgcagccagaggagggcacaggctggctgctggagctgctgtccgaggtgcagctgcaa
cagtacttcctgcggctccgagatgacctcaacgtcacccgcctgtcccactttgagtac
gtcaagaatgaggacctggagaagatcggcatgggtcggcctggccagcggcggctgtgg
gaggctgtgaagaggaggaaggccttgtgcaaacgcaagtcgtggatgagtaaggtgttc
agtggaaagcgactggaggctgagttcccacctcatcactctcagagcaccttccggaag
acctcgcccgcccctgggggcccagcaggggaggggcccctgcagagcctcacctgcctc
attggggagaaggacctgcgcctcctggagaagctgggtgatggttcctttggcgtggtg
cgcaggggcgagtgggacgcgccctcagggaagacggtgagtgtggctgtgaagtgcctg
aagcccgatgtcctgagccagccagaagccatggacgacttcatccgggaggtcaatgcc
atgcactcgctcgaccaccgaaacctcatccgcctctacggggtggtgctcacgccgccc
atgaagatggtgacagagctggcacctctgggatcgttgttggaccggctacgtaagcac
cagggccacttcctcctggggactctgagccgctacgctgtgcaggtggctgagggcatg
ggctacctggagtccaagcgctttattcaccgtgacctggctgcccgcaatctgctgttg
gctacccgcgacctggtcaagatcggggactttgggctgatgcgagcactacctcagaat
gacgaccattacgtcatgcaggaacatcgcaaggtgcccttcgcctggtgtgcccccgag
agcctgaagacacgcaccttctcccatgccagcgacacctggatgttcggggtgacactg
tgggaaatgttcacctacggccaggagccctggatcggcctcaacggcagtcagatcctg
cataagatcgacaaggagggggagcggctgccccggcccgaggactgtccccaggacatc
tacaacgtcatggtccagtgctgggctcacaagccagaggacagacccacgtttgtggcc
ctgcgggacttcctgctggaggcccagcccacagacatgcgggcccttcaggactttgag
gaaccggacaagctgcacatccagatgaatgatgtcatcaccgtcatcgagggaagggcc
gagaactactggtggcgtggccagaacacacggacgctgtgtgtggggcccttccctcgc
aacgtggtgacctccgtggccggcctgtcggcccaggacatcagccagcccctgcagaac
agcttcatccacacagggcatggcgacagtgacccccgccactgctggggcttcccggac
aggattgacgaactgtatctgggaaaccccatggacccccccgacctcctgagcgtggaa
ctgagcacctcccggcccccccagcatctaggaggggtgaaaaaaccaacctatgaccct
gtgagcgaggaccaagaccccttgtccagcgacttcaagaggctgggcctgcggaagcca
ggcctgccccgagggctgtggctggcgaagccctcggcgcgggtgccgggcaccaaggcc
agccgaggcagcggggctgaggtcacgctcatcgacttcggtgaggagcccgtggtcccg
gccctacggccctgcgcgccctccctggcgcagctggccatggacgcctgctccctgctg
gacgagaccccgcctcagagccccacgcgggcactgccccggcccctgcaccccacgcct
gtggtggactgggacgcacgcccgctgccccccccgcccgcctatgacgacgtggcccag
gatgaggatgactttgagatctgctccatcaacagcaccctcgtgggcgcgggggtccct
gccgggcccagccagggccagaccaactacgcctttgtgcctgagcaggcgcggccgccc
cctcccctggaggacaacctgttcctcccgccccagggtgggggcaagccgcccagctcc
gcacagaccgcagagatcttccaggcgctacagcaggagtgcatgaggcaactgcaggct
ccggccggctccccggccccctctcccagcccggggggtgacgacaagccccaggtgcct
cctcgggtacccatcccccctcggcccacgcgcccacacgtccagctgtctccagccccc
ccgggcgaggaggagaccagccagtggcctggacctgcttcccctccccgggtgcctccg
cgggagcccctgtcccctcaaggctcgaggacacccagccccctggtaccacctggcagc
tccccgctgccaccccggctctcaagctcacctgggaagaccatgcccaccacccagagc
tttgcctcagaccccaagtacgccaccccccaggtgatccaggcccctggcccgcgggct
ggtccctgcatcctgcccatcgtccgggatggcaagaaggtcagcagcacccactattac
ttgctgcccgagcgaccatcctacctggagcgctaccagcgcttcctgcgtgaggcccag
agccccgaggagcctacccccctgcctgtgcctctgctgctgcccccacccagcacccca
gcccccgccgcccccacggccaccgtgcggccgatgccccaggctgccttggaccccaag
gccaacttctccaccaacaacagcaacccaggggcccggccaccacccccgagggccact
gctcggctgccacagaggggctgccctggcgatgggccagaggcgggccggccagcagac
aagatccagatggccatggtgcatggggtgaccacagaggagtgccaggcggccctgcag
tgccacggctggagcgtgcagagggctgcccagtatctgaaggtggagcagctcttcggg
ctgggtctgcggcccagaggggagtgccacaaagtgctggagatgttcgactggaacctg
gagcaggccggctgccaccttctgggctcctggggccctgcccaccacaagcgctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (34)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (95)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (92)   
DNA sequence (137)   
   RefSeq(nuc) (107)   
   GenBank (15)   
   EMBL (15)   
3D Structure (18)   
   PDB (18)   
Protein domain (11)   
   Pfam (11)   
All databases (296)   

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