KEGG   Homo sapiens (human): 10188
Entry
10188             CDS       T01001                                 

Gene name
TNK2, ACK, ACK-1, ACK1, p21cdc42Hs
Definition
(RefSeq) tyrosine kinase non receptor 2
  KO
K08886  activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    10188 (TNK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     10188 (TNK2)
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     10188 (TNK2)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  ACK family
   10188 (TNK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase GTPase_binding Inhibitor_Mig-6 SH3_9 UBA_4 Kinase-like SH3_1 SH3_2 SAM_2
Other DBs
NCBI-GeneID: 10188
NCBI-ProteinID: NP_005772
OMIM: 606994
HGNC: 19297
Ensembl: ENSG00000061938
Vega: OTTHUMG00000155737
Pharos: Q07912(Tchem)
UniProt: Q07912 B3KXJ4
Structure
PDB: 

Position
3q29
AA seq 1038 aa
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP
GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP
AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA
PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA
GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP
APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD
KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL
EQAGCHLLGSWGPAHHKR
NT seq 3117 nt   +upstreamnt  +downstreamnt
atgcagccagaggagggcacaggctggctgctggagctgctgtccgaggtgcagctgcaa
cagtacttcctgcggctccgagatgacctcaacgtcacccgcctgtcccactttgagtac
gtcaagaatgaggacctggagaagatcggcatgggtcggcctggccagcggcggctgtgg
gaggctgtgaagaggaggaaggccttgtgcaaacgcaagtcgtggatgagtaaggtgttc
agtggaaagcgactggaggctgagttcccacctcatcactctcagagcaccttccggaag
acctcgcccgcccctgggggcccagcaggggaggggcccctgcagagcctcacctgcctc
attggggagaaggacctgcgcctcctggagaagctgggtgatggttcctttggcgtggtg
cgcaggggcgagtgggacgcgccctcagggaagacggtgagtgtggctgtgaagtgcctg
aagcccgatgtcctgagccagccagaagccatggacgacttcatccgggaggtcaatgcc
atgcactcgctcgaccaccgaaacctcatccgcctctacggggtggtgctcacgccgccc
atgaagatggtgacagagctggcacctctgggatcgttgttggaccggctacgtaagcac
cagggccacttcctcctggggactctgagccgctacgctgtgcaggtggctgagggcatg
ggctacctggagtccaagcgctttattcaccgtgacctggctgcccgcaatctgctgttg
gctacccgcgacctggtcaagatcggggactttgggctgatgcgagcactacctcagaat
gacgaccattacgtcatgcaggaacatcgcaaggtgcccttcgcctggtgtgcccccgag
agcctgaagacacgcaccttctcccatgccagcgacacctggatgttcggggtgacactg
tgggaaatgttcacctacggccaggagccctggatcggcctcaacggcagtcagatcctg
cataagatcgacaaggagggggagcggctgccccggcccgaggactgtccccaggacatc
tacaacgtcatggtccagtgctgggctcacaagccagaggacagacccacgtttgtggcc
ctgcgggacttcctgctggaggcccagcccacagacatgcgggcccttcaggactttgag
gaaccggacaagctgcacatccagatgaatgatgtcatcaccgtcatcgagggaagggcc
gagaactactggtggcgtggccagaacacacggacgctgtgtgtggggcccttccctcgc
aacgtggtgacctccgtggccggcctgtcggcccaggacatcagccagcccctgcagaac
agcttcatccacacagggcatggcgacagtgacccccgccactgctggggcttcccggac
aggattgacgaactgtatctgggaaaccccatggacccccccgacctcctgagcgtggaa
ctgagcacctcccggcccccccagcatctaggaggggtgaaaaaaccaacctatgaccct
gtgagcgaggaccaagaccccttgtccagcgacttcaagaggctgggcctgcggaagcca
ggcctgccccgagggctgtggctggcgaagccctcggcgcgggtgccgggcaccaaggcc
agccgaggcagcggggctgaggtcacgctcatcgacttcggtgaggagcccgtggtcccg
gccctacggccctgcgcgccctccctggcgcagctggccatggacgcctgctccctgctg
gacgagaccccgcctcagagccccacgcgggcactgccccggcccctgcaccccacgcct
gtggtggactgggacgcacgcccgctgccccccccgcccgcctatgacgacgtggcccag
gatgaggatgactttgagatctgctccatcaacagcaccctcgtgggcgcgggggtccct
gccgggcccagccagggccagaccaactacgcctttgtgcctgagcaggcgcggccgccc
cctcccctggaggacaacctgttcctcccgccccagggtgggggcaagccgcccagctcc
gcacagaccgcagagatcttccaggcgctacagcaggagtgcatgaggcaactgcaggct
ccggccggctccccggccccctctcccagcccggggggtgacgacaagccccaggtgcct
cctcgggtacccatcccccctcggcccacgcgcccacacgtccagctgtctccagccccc
ccgggcgaggaggagaccagccagtggcctggacctgcttcccctccccgggtgcctccg
cgggagcccctgtcccctcaaggctcgaggacacccagccccctggtaccacctggcagc
tccccgctgccaccccggctctcaagctcacctgggaagaccatgcccaccacccagagc
tttgcctcagaccccaagtacgccaccccccaggtgatccaggcccctggcccgcgggct
ggtccctgcatcctgcccatcgtccgggatggcaagaaggtcagcagcacccactattac
ttgctgcccgagcgaccatcctacctggagcgctaccagcgcttcctgcgtgaggcccag
agccccgaggagcctacccccctgcctgtgcctctgctgctgcccccacccagcacccca
gcccccgccgcccccacggccaccgtgcggccgatgccccaggctgccttggaccccaag
gccaacttctccaccaacaacagcaacccaggggcccggccaccacccccgagggccact
gctcggctgccacagaggggctgccctggcgatgggccagaggcgggccggccagcagac
aagatccagatggccatggtgcatggggtgaccacagaggagtgccaggcggccctgcag
tgccacggctggagcgtgcagagggctgcccagtatctgaaggtggagcagctcttcggg
ctgggtctgcggcccagaggggagtgccacaaagtgctggagatgttcgactggaacctg
gagcaggccggctgccaccttctgggctcctggggccctgcccaccacaagcgctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (22)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (49)   
   RefSeq(nuc) (19)   
   GenBank (15)   
   EMBL (15)   
Protein domain (10)   
   Pfam (10)   
All databases (125)   

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