KEGG   Homo sapiens (human): 10297
Entry
10297             CDS       T01001                                 
Symbol
APC2, APCL, MRT74
Name
(RefSeq) APC regulator of WNT signaling pathway 2
  KO
K02085  adenomatosis polyposis coli protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04810  Regulation of actin cytoskeleton
hsa04934  Cushing syndrome
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Disease
H00718  Sotos syndrome
H00768  Autosomal recessive intellectual developmental disorder
H01667  Medulloblastoma
H01881  Complex cortical dysplasia with other brain malformations
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    10297 (APC2)
   04390 Hippo signaling pathway
    10297 (APC2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    10297 (APC2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    10297 (APC2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    10297 (APC2)
   05206 MicroRNAs in cancer
    10297 (APC2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    10297 (APC2)
   05225 Hepatocellular carcinoma
    10297 (APC2)
   05226 Gastric cancer
    10297 (APC2)
   05217 Basal cell carcinoma
    10297 (APC2)
   05213 Endometrial cancer
    10297 (APC2)
   05224 Breast cancer
    10297 (APC2)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    10297 (APC2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10297 (APC2)
   05022 Pathways of neurodegeneration - multiple diseases
    10297 (APC2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    10297 (APC2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    10297 (APC2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10297 (APC2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10297 (APC2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     10297 (APC2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centriole associated proteins
    10297 (APC2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EB / APC
     10297 (APC2)
SSDB
Motif
Pfam: APC_basic APC_rep APC_N_CC APC_r Arm Arm_APC_u3 Suppressor_APC SAMP bZIP_1 Sec7-like_HUS HALZ CCDC138_cc
Other DBs
NCBI-GeneID: 10297
NCBI-ProteinID: NP_005874
OMIM: 612034
HGNC: 24036
Ensembl: ENSG00000115266
UniProt: O95996
Position
19:1446230..1473244
AA seq 2303 aa
MASSVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQE
ARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTLGPEPAARTPEGSPVHGSGPSKDSF
GELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQM
DLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQA
LLAVKSVPVDEDPETEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSS
SPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPD
QGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMK
LSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVAN
KATLCARRGCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQC
VLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESG
GGILRNVSSLVATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQ
ELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYV
RKQRALEAELDARHLAQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDD
DDAPSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVA
AKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEG
GRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCG
QPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGPG
ISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAG
RPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVE
DATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPD
SPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGS
VRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRR
REEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAP
APAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMG
HRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTT
PTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPP
PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSP
SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASD
LDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQ
AEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPA
PRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPR
SATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQ
HKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALS
SGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCS
SRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA
SLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRS
TLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAG
GQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPM
VVAATTDSAAEKAPATASATLLE
NT seq 6912 nt   +upstreamnt  +downstreamnt
atggcgagctccgtggcgccctacgagcagctggtgaggcaggtggaggccttgaaggct
gagaacagccacctgaggcaggagctaagggacaactccagccacctgtccaagctggag
acagagacgtcgggcatgaaggaggtcctgaagcacctacagggaaaactggagcaggag
gcccgagtgctggtgtcctcggggcagacggaggtgctggagcagctgaaggccctacag
atggacatcaccagcctgtacaacctcaagttccagccgcccaccctgggcccggagcct
gccgcccggacccccgagggcagcccagtacacggctccgggccctccaaggacagcttt
ggggagctgagccgggccaccatccggctgctggaggaactggaccgggaacggtgtttc
ctgctgaatgagattgagaaggaggagaaggagaagctctggtactactctcagctgcag
ggcctgtccaagcgcctggacgagctgccgcacgtggagacgcagttctcgatgcagatg
gacctgatccggcagcagcttgagttcgaggcccagcacatccgctcgctgatggaggag
cgcttcggcacctcggacgagatggtgcagcgggcacagatccgcgcctcgcgcctggag
cagattgacaaggagctgctggaggcgcaggaccgagtgcagcagacggagccccaggcc
ttgctggcggtgaagtcggtgccggtggacgaggaccccgagacagaggtccccacacac
cctgaggatggcacccctcagccgggcaacagcaaggtggaggtggtcttctggctgttg
tccatgttggcgacgcgcgaccaggaggatacagcgcgcacgctgctggccatgtccagc
tcgcccgagagctgcgtggccatgcgccgctcgggctgtctgcctctgctgctgcaaatc
ctccacggcaccgaggccgcggccgggggtcgcgccggggccccaggggcaccgggcgcc
aaggacgcacgcatgcgcgccaacgcggcgctgcacaacatcgtcttctcgcagccggac
cagggcctggcgcgcaaggagatgcgcgtcctgcacgtgctggagcagatccgggcctac
tgcgagacctgctgggactggctgcaggcccgagacggcgggcccgagggaggtggcgcc
ggcagcgccccgatccccatcgagccgcagatctgccaggccacctgtgctgttatgaag
ctgtcctttgatgaggagtaccgccgtgccatgaacgagctaggtgggctgcaggccgtg
gcagagctgctgcaggttgactatgagatgcacaagatgacccgggacccgctgaacctg
gcgctgcgccgctacgcgggcatgaccctcaccaacctcacctttggggacgttgccaac
aaggccaccctgtgtgcgcgccgcggctgcatggaggccatcgtggcccagctggcctcc
gacagtgaggagctccaccaggtggtgtccagcatccttcggaacttgtcctggagggcc
gacatcaacagcaagaaggtgctgagggaggcgggcagcgtgactgccctggtgcagtgt
gtcctgcgggccaccaaggagtccaccctgaagagcgtgctgagcgccctgtggaatctg
tctgcacacagcacagagaacaaggcggccatctgccaggtggatggcgccctgggcttc
ctggtgagcaccctgacctacaagtgtcagagcaactcgctggccatcatcgagagcggc
ggcggcatcctccgcaatgtgtccagcctcgtcgccacccgtgaggactacaggcaggtg
ctccgggatcacaactgtctgcagacgctgctgcagcatctgacttcgcacagcctgacc
atcgtgagcaacgcgtgcggcacgctctggaacctgtcggcccgcagcgcccgtgaccag
gagctgctgtgggacctgggcgccgtgggcatgctgcgtaatctggtgcactccaagcac
aagatgatcgccatgggcagcgccgccgccctgcgcaacctgctggcccatcggcccgcc
aagcaccaggcggccgccaccgccgtgtccccaggcagctgcgtgcccagcctgtacgtg
cgcaagcagcgggcgctggaggccgagctggacgcacggcacctcgcgcaggcgctggag
cacctggagaagcagggcccgccggcagccgaggccgccactaagaagccgctgccgccc
ctgcgacacctggacggcctggcccaagactatgcttccgattcgggctgctttgacgac
gacgatgcaccgtcatccctggctgcggccgcggccaccggggagccagccagccctgcc
gcgctgtccctcttcctgggcagccccttcctgcaggggcaggcgctggctcgcaccccg
cccacccgccgaggcggcaaggaggcagagaaggacaccagtggggaggcagccgtggcg
gccaaggccaaggccaagctggcgcttgcagtggcgcgcatcgaccagctggtggaggac
atctccgccctgcacacctcgtccgacgatagcttcagcctcagctctggagacccggga
caggaggcgccacgggagggccgcgcccagtcctgctcgccatgccgcggcccggagggc
gggcggcgagaggcaggaagccgggcgcacccgctgctgcggctcaaggcggcccacgcc
agcctctccaacgacagcctcaacagcggcagtgccagcgacgggtactgcccacgcgaa
catatgctgccctgcccgctggccgcactggcttcgcgccgcgaggaccccaggtgtggg
cagcctcggcccagccggcttgaccttgacctgcccggctgccaggccgagcccccggcc
cgcgaggccacctccgccgacgcccgcgtgcgcaccatcaagctgtcgcctacctatcag
cacgtgccactgcttgagggtgcctcaagggcgggtgcagagcccctcgcggggcctgga
atctctccaggggcccggaagcaggcctggctgccggcagaccacctgagcaaggttccc
gagaagctggcggctgccccgctgtctgtggccagcaaggcactgcagaaactggcggcg
caagaggggccactctcgctgtcccgatgcagctccctttcctcgctgtcctcggccggc
cgcccaggccccagcgagggtggtgacctggatgacagtgactcctccctggaggggctg
gaggaggccggccccagcgaggctgagctggacagcacgtggcgggcgcccggggccacc
tcgctgcccgtagccattccggctccccggcgtaaccgaggccggggcctgggggtggaa
gacgccacgccgtccagctcgtcggagaactacgtgcaggagacaccgcttgtgctgagc
cgctgcagctctgtgagctcgctgggcagcttcgagagcccgtccatcgccagctccatc
cccagtgaaccttgcagcgggcagggcagcggcaccatcagccctagcgagctgcccgac
agccccggacagaccatgcctcccagccggagcaagacgccaccgctggcgcccgcgcca
cagggtccccccgaggccacccagttcagcctgcagtgggagagctacgtgaagcgcttc
ctggacatcgccgactgccgggagcgctgccggctgccatctgagctggacgcaggcagc
gtgcgctttaccgtggagaagccagacgagaacttctcgtgcgcctccagcctcagcgcg
ctggccttgcacgagcactacgtgcagcaggacgtggagctgcggctgctgccctcggcc
tgccccgagcgcggcgggggcgccgggggcgccggcctccactttgcagggcaccggcgg
cgggaggaggggccggcgcccacgggttctcgccctcgcggcgccgcggaccaggagctg
gaactgctgcgggagtgcctgggagccgccgtgcctgcccggctgcgcaaggtggcctcc
gcgctggtgccaggtcgccgcgcactccccgtgcccgtctacatgttggtgcccgccccg
gccccggcccaggaggacgactcctgcactgactccgcggagggcacgccggtcaacttc
tctagcgccgcctcgctcagcgacgagacgctgcagggaccccccagggaccagcccggg
ggaccagcgggcaggcaaagacccaccggccgccccacctctgccagacaggccatgggg
caccggcacaaggcgggaggcgccggccgcagcgcggagcagtctcggggcgcgggcaag
aacagagcagggctggagctgcccctgggccggcccccgagcgcccccgcagacaaggac
ggctcaaagcccggccggacccgcggggacggggcgctccagtcgctgtgcctcacgacg
cccactgaggaggccgtgtactgcttctacggcaacgactcggacgaggagcccccggcg
gccgcgcccacgccaacccaccggcgcacatcggccatccctcgcgcttttacgcgggag
cgtccgcagggccggaaggaggcccctgccccgtccaaggctgcaccagctgccccgccg
cccgcccggacccagcccagcctcattgctgacgagaccccgccctgctactccctgagc
tcctccgccagctccctcagcgagcccgagccctcggagccgccggccgtccatccacga
ggccgggagcccgcggtcaccaaggacccgggcccaggaggcggacgcgacagctcgccc
agcccgcgggccgcggaggagcttctgcagcggtgcatcagctcggccctgcccaggcgc
cggccccccgtgtctggcctgcggcgccgcaagccccgagccacccggctggatgagcgg
cccgcagaggggtcccgggaacgcggcgaggaggcagcgggctcggaccgggcctccgac
ctggatagcgtggagtggcgcgccatccaggagggcgccaattcaattgtcacgtggctg
caccaggcagcagctgccacgcgggaggcctcgtccgagtccgactccatcctgtccttc
gtatccgggctgtcagtgggatccaccctacagccccccaagcacaggaagggacgacag
gcggagggagaaatgggcagtgcccggcggccagagaaaaggggcgcagcctcagtcaag
accagcgggagcccccgttcccctgcaggccccgagaagccacgtggcacacagaagacc
acgcccggggtgccagctgtgctccggggacgaacagtgatctacgtccccagcccggca
ccccgtgcccagcccaaagggacccccggcccccgcgccacaccgcggaaggtggcgccc
ccttgcctggcacagcccgcggctccagccaaagtcccgagccccgggcagcagcggtcg
cggagcctacaccggcctgccaagacctcggagctggcgacgctgagccagccccccaga
agcgccacaccgcccgcccgcctcgccaagaccccctcctccagctcctcccagacctcg
cccgcctcccagcccctgcccagaaagcgccccccggtcacccaggctgctggggccctg
cccggccccggagcctccccggtgcccaaaacgccggcgcgcacccttctggcgaagcag
cacaagacgcagagatcgcccgtgcggatcccgttcatgcagaggccggcccggcgtggg
ccgccaccgctggctcgggcagtcccggagccgggccccaggggccgggcggggaccgag
gcgggcccgggggcgcgcgggggccgcctgggcctggtgcgtgtggcctcagccctctcc
agcggcagcgagtcctccgaccgctcgggcttccggcgacagctaaccttcatcaaggag
tcgccgggcttgcggcgccgccgctccgagctgtcctcggccgagtccgcggcctctgcc
ccccagggcgcctcgccccgccgcggccggcccgcgctgcccgccgtcttcctctgctcc
tcgcgctgcgaagagctccgagcggcaccccggcagggcccggccccggcccggcagcgg
ccccccgcggcccgacccagccctggcgagcgccctgcccggcgcaccacctccgagagc
ccgtcccgcctgcctgtgcgcgcgcccgccgcccggccggagactgtcaagcgctacgcg
tcgctgccgcacatcagcgtggcccgcaggcccgacggcgccgtccccgcggcccctgcc
tcagccgacgccgcgcgccgcagcagcgacggggagccccggccgctccccagggtggcc
gcgccgggcacgacctggcggcgcatccgagatgaggacgtgccccacatcctgcgcagc
acgcttcccgccacggccctgccactgcggggctccacgcccgaggacgccccggccggg
cccccgccgcgcaagaccagcgacgccgtggtccagaccgaggaggtcgccgcccccaag
accaactccagcacgtccccgagcctggagaccagggagccccccggggcccccgccggc
ggccagctctccctcctcggcagcgacgtggacggtcccagcctcgccaaggctcccatc
tccgcacccttcgtgcacgagggcctgggggtcgccgtggggggcttccccgccagccgg
cacggctcccccagccgctcggcccgagtaccccccttcaactatgtgcccagccccatg
gtggtcgcagccaccaccgactcggccgcggagaaagccccggccactgcctccgccacc
ctcctggaatag

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (16)   
   KEGG PATHWAY (16)   
Disease (7)   
   KEGG DISEASE (4)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (109)   
   KEGG ORTHOLOGY (1)   
   RefGene (103)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (18)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (30)   
   RefSeq(nuc) (16)   
   GenBank (7)   
   EMBL (7)   
Protein domain (12)   
   Pfam (12)   
All databases (197)   

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