KEGG   Homo sapiens (human): 1398
Entry
1398              CDS       T01001                                 

Gene name
CRK, CRKII, p38
Definition
(RefSeq) CRK proto-oncogene, adaptor protein
  KO
K04438  C-crk adapter molecule crk
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04015  Rap1 signaling pathway
hsa04062  Chemokine signaling pathway
hsa04510  Focal adhesion
hsa04666  Fc gamma R-mediated phagocytosis
hsa04722  Neurotrophin signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05135  Yersinia infection
hsa05163  Human cytomegalovirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05211  Renal cell carcinoma
hsa05220  Chronic myeloid leukemia
Network
nt06124  Chemokine signaling (viruses)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06167  Human cytomegalovirus (HCMV)
nt06214  PI3K signaling
nt06276  Chronic myeloid leukemia
  Element
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00414  HCMV US27 to CXCR4-GNB/G-PLCB-PKC signaling pathway
N01068  ITGA/B-FAK-RAC signaling pathway
N01090  IGG-FCGR-RAC signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1398 (CRK)
   04012 ErbB signaling pathway
    1398 (CRK)
   04015 Rap1 signaling pathway
    1398 (CRK)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    1398 (CRK)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1398 (CRK)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    1398 (CRK)
   04062 Chemokine signaling pathway
    1398 (CRK)
  09152 Endocrine system
   04910 Insulin signaling pathway
    1398 (CRK)
   04935 Growth hormone synthesis, secretion and action
    1398 (CRK)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    1398 (CRK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1398 (CRK)
   05206 MicroRNAs in cancer
    1398 (CRK)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    1398 (CRK)
   05211 Renal cell carcinoma
    1398 (CRK)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    1398 (CRK)
   05163 Human cytomegalovirus infection
    1398 (CRK)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    1398 (CRK)
   05135 Yersinia infection
    1398 (CRK)
   05100 Bacterial invasion of epithelial cells
    1398 (CRK)
Motif
Pfam: SH3_2 SH2 SH3_1 SH3_9 SH3_10 DUF3804
Other DBs
NCBI-GeneID: 1398
NCBI-ProteinID: NP_058431
OMIM: 164762
HGNC: 2362
Ensembl: ENSG00000167193
Vega: OTTHUMG00000090317
Pharos: P46108(Tbio)
UniProt: P46108 A0A0S2Z3Q4 L7RT18
Structure
PDB: 

Position
17p13.3
AA seq 304 aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
EDFS
NT seq 915 nt   +upstreamnt  +downstreamnt
atggcgggcaacttcgactcggaggagcggagtagctggtactgggggaggttgagtcgg
caggaggcggtggcgctgctgcagggccagcggcacggggtgttcctggtgcgggactcg
agcaccagccccggggactatgtgctcagcgtctcagagaactcgcgcgtctcccactac
atcatcaacagcagcggcccgcgcccgccggtgccaccgtcgcccgcccagcctccgccc
ggggtgagcccctccagactccgaataggagatcaagagtttgattcattgcctgcttta
ctggaattctacaaaatacactatttggacactacaacgttgatagaaccagtttccaga
tccaggcagggtagtggagtgattctcaggcaggaggaggcggagtatgtgcgagccctc
tttgactttaatgggaatgatgaggaagatcttccctttaagaaaggagacatcttgaga
atccgggacaagcctgaagagcagtggtggaatgcggaggacagcgaaggcaagagaggg
atgattccagtcccttacgtcgagaagtatagacctgcctccgcctcagtatcggctctg
attggaggtaaccaggagggttcccacccacagccactgggtgggccggagcctgggccc
tatgcccaacccagcgtcaacactccgctccctaacctccagaatgggcccatatatgcc
agggttatccagaagcgagtccccaatgcctacgacaagacagccttggctttggaggtc
ggtgagctggtaaaggttacgaagattaatgtgagtggtcagtgggaaggggagtgtaat
ggcaaacgaggtcacttcccattcacacatgtccgtctgctggatcaacagaatcccgat
gaggacttcagctga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (19)   
   KEGG PATHWAY (19)   
Network (5)   
   KEGG NETWORK (5)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
Protein domain (6)   
   Pfam (6)   
All databases (79)   

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KEGG   Homo sapiens (human): 1399
Entry
1399              CDS       T01001                                 

Gene name
CRKL
Definition
(RefSeq) CRK like proto-oncogene, adaptor protein
  KO
K04438  C-crk adapter molecule crk
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04015  Rap1 signaling pathway
hsa04062  Chemokine signaling pathway
hsa04510  Focal adhesion
hsa04666  Fc gamma R-mediated phagocytosis
hsa04722  Neurotrophin signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05135  Yersinia infection
hsa05163  Human cytomegalovirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05211  Renal cell carcinoma
hsa05220  Chronic myeloid leukemia
Network
nt06214  PI3K signaling
nt06276  Chronic myeloid leukemia
  Element
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1399 (CRKL)
   04012 ErbB signaling pathway
    1399 (CRKL)
   04015 Rap1 signaling pathway
    1399 (CRKL)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    1399 (CRKL)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1399 (CRKL)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    1399 (CRKL)
   04062 Chemokine signaling pathway
    1399 (CRKL)
  09152 Endocrine system
   04910 Insulin signaling pathway
    1399 (CRKL)
   04935 Growth hormone synthesis, secretion and action
    1399 (CRKL)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    1399 (CRKL)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1399 (CRKL)
   05206 MicroRNAs in cancer
    1399 (CRKL)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    1399 (CRKL)
   05211 Renal cell carcinoma
    1399 (CRKL)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    1399 (CRKL)
   05163 Human cytomegalovirus infection
    1399 (CRKL)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    1399 (CRKL)
   05135 Yersinia infection
    1399 (CRKL)
   05100 Bacterial invasion of epithelial cells
    1399 (CRKL)
Motif
Pfam: SH3_2 SH2 SH3_1 SH3_9 hSH3
Other DBs
NCBI-GeneID: 1399
NCBI-ProteinID: NP_005198
OMIM: 602007
HGNC: 2363
Ensembl: ENSG00000099942
Vega: OTTHUMG00000150807
Pharos: P46109(Tbio)
UniProt: P46109
Structure
PDB: 

Position
22q11.21
AA seq 303 aa
MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH
YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT
AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK
LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA
KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD
ENE
NT seq 912 nt   +upstreamnt  +downstreamnt
atgtcctccgccaggttcgactcctcggaccgctccgcctggtatatggggccggtgtct
cgccaggaggcgcagacccggctccagggccagcgccacggtatgttcctcgtccgcgat
tcttccacctgccctggggactatgtgctgtcggtgtccgagaactcgcgggtctcccac
tacatcatcaactcgctgcccaaccgccgttttaagatcggggaccaggaatttgaccat
ttgccggccctgctggagttttacaagatccactacctggacaccaccaccctcatcgag
cctgcgcccaggtatccaagcccaccaatgggatctgtctcagcacccaacctgcctaca
gcagaagataacctggaatatgtacggactctgtatgattttcctgggaatgatgccgaa
gacctgccctttaaaaagggtgagatcctagtgataatagagaagcctgaagaacagtgg
tggagtgcccggaacaaggatggccgggttgggatgattcctgtcccttatgtcgaaaag
cttgtgagatcctcaccacacggaaagcatggaaataggaattccaacagttatgggatc
ccagaacctgctcatgcatacgctcaacctcagaccacaactcctctacctgcagtttcc
ggttctcctggggcagcaatcacccctttgccatccacacagaatggacctgtctttgcg
aaagcaatccagaaaagagtaccctgtgcttatgacaagactgccttggcattagaggtt
ggtgacatcgtgaaagtcacaaggatgaatataaatggccagtgggaaggcgaagtgaac
gggcgcaaagggcttttcccctttacgcacgtcaaaatctttgaccctcaaaacccagat
gaaaacgagtga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (19)   
   KEGG PATHWAY (19)   
Network (1)   
   KEGG NETWORK (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
Protein domain (5)   
   Pfam (5)   
All databases (68)   

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