KEGG   Homo sapiens (human): 1543Help
Entry
1543              CDS       T01001                                 

Gene name
CYP1A1, AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX
Definition
(RefSeq) cytochrome P450 family 1 subfamily A member 1
  KO
K07408  cytochrome P450 family 1 subfamily A polypeptide 1 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00380  Tryptophan metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
hsa05204  Chemical carcinogenesis
Network
N00317  Aryl hydrocarbon receptor signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1543 (CYP1A1)
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    1543 (CYP1A1)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1543 (CYP1A1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1543 (CYP1A1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian Steroidogenesis
    1543 (CYP1A1)
 09160 Human Diseases
  09161 Cancers
   05204 Chemical carcinogenesis
    1543 (CYP1A1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1543 (CYP1A1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1543 (CYP1A1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP1 family
   1543 (CYP1A1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: p450
Motif
Other DBs
NCBI-GeneID: 1543
NCBI-ProteinID: NP_000490
OMIM: 108330
HGNC: 2595
Ensembl: ENSG00000140465
Vega: OTTHUMG00000142812
Pharos: P04798(Tchem)
UniProt: P04798 A0N0X8
Structure
PDB: 

Position
15q24.1
AA seq 512 aa AA seqDB search
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
NT seq 1539 nt NT seq  +upstreamnt  +downstreamnt
atgcttttcccaatctccatgtcggccacggagtttcttctggcctctgtcatcttctgt
ctggtattctgggtaatcagggcctcaagacctcaggtccccaaaggcctgaagaatcca
ccagggccatggggctggcctctgattgggcacatgctgaccctgggaaagaacccgcac
ctggcactgtcaaggatgagccagcagtatggggacgtgctgcagatccgaattggctcc
acacccgtggtggtgctgagcggcctggacaccatccggcaggccctggtgcggcagggc
gatgatttcaagggccggcccgacctctacaccttcaccctcatcagtaatggtcagagc
atgtccttcagcccagactctggaccagtgtgggctgcccgccggcgcctggcccagaat
ggcctgaaaagtttctccattgcctctgacccagcctcctcaacctcctgctacctggaa
gagcatgtgagcaaggaggctgaggtcctgataagcacgttgcaggagctgatggcaggg
cctgggcactttaacccctacaggtatgtggtggtatcagtgaccaatgtcatctgtgcc
atttgctttggccggcgctatgaccacaaccaccaagaactgcttagcctagtcaacctg
aataataatttcggggaggtggttggctctggaaacccagctgacttcatccctattctt
cgctacctacccaacccttccctgaatgccttcaaggacctgaatgagaagttctacagc
ttcatgcagaagatggtcaaggagcactacaaaacctttgagaagggccacatccgggac
atcacagacagcctgattgagcactgtcaggagaagcagctggatgagaacgccaatgtc
cagctgtcagatgagaagatcattaacatcgtcttggacctctttggagctgggtttgac
acagtcacaactgctatctcctggagcctcatgtatttggtgatgaaccccagggtacag
agaaagatccaagaggagctagacacagtgattggcaggtcacggcggccccggctctct
gacagatcccatctgccctatatggaggccttcatcctggagaccttccgacactcttcc
ttcgtccccttcaccatcccccacagcacaacaagagacacaagtttgaaaggcttttac
atccccaaggggcgttgtgtctttgtaaaccagtggcagatcaaccatgaccagaagcta
tgggtcaacccatctgagttcctacctgaacggtttctcacccctgatggtgctatcgac
aaggtgttaagtgagaaggtgattatctttggcatgggcaagcggaagtgtatcggtgag
accattgcccgctgggaggtctttctcttcctggctatcctgctgcaacgggtggaattc
agcgtgccactgggcgtgaaggtggacatgacccccatctatgggctaaccatgaagcat
gcctgctgtgagcacttccaaatgcagctgcgctcttag

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