| Entry |
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| Symbol |
AKR1C2, AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
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| Name |
(RefSeq) aldo-keto reductase family 1 member C2
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| KO |
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| Organism |
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| Pathway |
| hsa05204 | Chemical carcinogenesis - DNA adducts |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
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| Network |
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| Element |
| N01401 | Benzo[a]pyrenre to CYP-mediated metabolism |
| N01413 | Metals to KEAP1-NRF2 signalig pathway |
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| Disease |
| H00607 | 46,XY gonadal dysgenesis |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
1646 (AKR1C2)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
1646 (AKR1C2)
05208 Chemical carcinogenesis - reactive oxygen species
1646 (AKR1C2)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1646 (AKR1C2)
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
1646 (AKR1C2)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
10:complement(4987775..5018000)
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| AA seq |
323 aa
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY |
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| NT seq |
972 nt +upstreamnt +downstreamnt
atggattcgaaataccagtgtgtgaagctgaatgatggtcacttcatgcctgtcctggga
tttggcacctatgcgcctgcagaggttcctaaaagtaaagctctagaggccgtcaaattg
gcaatagaagccgggttccaccatattgattctgcacatgtttacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggagcaattcccatcgaccagagttggtccgaccagccttggaa
aggtcactgaaaaatcttcaattggactatgttgacctctatcttattcattttccagtg
tctgtaaagccaggtgaggaagtgatcccaaaagatgaaaatggaaaaatactatttgac
acagtggatctctgtgccacatgggaggccatggagaagtgtaaagatgcaggattggcc
aagtccatcggggtgtccaacttcaaccacaggctgctggagatgatcctcaacaagcca
gggctcaagtacaagcctgtctgcaaccaggtggaatgtcatccttacttcaaccagaga
aaactgctggatttctgcaagtcaaaagacattgttctggttgcctatagtgctctggga
tcccatcgagaagaaccatgggtggacccgaactccccggtgctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaac
gtgcaggtgtttgaattccagttgacttcagaggagatgaaagccatagatggcctaaac
agaaatgtgcgatatttgacccttgatatttttgctggcccccctaattatccattttct
gatgaatattaa |
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