KEGG   Homo sapiens (human): 1675Help
Entry
1675              CDS       T01001                                 

Gene name
CFD, ADIPSIN, ADN, DF, PFD
Definition
(RefSeq) complement factor D
  KO
K01334  complement factor D [EC:3.4.21.46]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa05150  Staphylococcus aureus infection
Disease
H00104  Alternative complement pathway component defects
Drug target
Danicopan: D11641
Lampalizumab: D10440
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    1675 (CFD)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    1675 (CFD)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1675 (CFD)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.46  complement factor D
     1675 (CFD)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   1675 (CFD)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Trypsin DUF1986 Trypsin_2
Motif
Other DBs
NCBI-GeneID: 1675
NCBI-ProteinID: NP_001919
OMIM: 134350
HGNC: 2771
Ensembl: ENSG00000197766
Vega: OTTHUMG00000181840
Pharos: P00746(Tchem)
UniProt: P00746
Structure
PDB: 

Position
19p13.3
AA seq 253 aa AA seqDB search
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
NT seq 762 nt NT seq  +upstreamnt  +downstreamnt
atgcacagctgggagcgcctggcagttctggtcctcctaggagcggccgcctgcgcggcg
ccgccccgtggtcggatcctgggcggcagagaggccgaggcgcacgcgcggccctacatg
gcgtcggtgcagctgaacggcgcgcacctgtgcggcggcgtcctggtggcggagcagtgg
gtgctgagcgcggcgcactgcctggaggacgcggccgacgggaaggtgcaggttctcctg
ggcgcgcactccctgtcgcagccggagccctccaagcgcctgtacgacgtgctccgcgca
gtgccccacccggacagccagcccgacaccatcgaccacgacctcctgctgctacagctg
tcggagaaggccacactgggccctgctgtgcgccccctgccctggcagcgcgtggaccgc
gacgtggcaccgggaactctctgcgacgtggccggctggggcatagtcaaccacgcgggc
cgccgcccggacagcctgcagcacgtgctcttgccagtgctggaccgcgccacctgcaac
cggcgcacgcaccacgacggcgccatcaccgagcgcttgatgtgcgcggagagcaatcgc
cgggacagctgcaagggtgactccgggggcccgctggtgtgcgggggcgtgctcgagggc
gtggtcacctcgggctcgcgcgtttgcggcaaccgcaagaagcccgggatctacacccgc
gtggcgagctatgcggcctggatcgacagcgtcctggcctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (30)   
   RefSeq(nuc) (2)   
   GenBank (14)   
   EMBL (14)   
Protein domain (3)   
   Pfam (3)   
All databases (64)   

Download RDF
DBGET integrated database retrieval system