KEGG   Homo sapiens (human): 1723
Entry
1723              CDS       T01001                                 
Symbol
DHODH, DHOdehase, POADS, URA1
Name
(RefSeq) dihydroorotate dehydrogenase (quinone)
  KO
K00254  dihydroorotate dehydrogenase [EC:1.3.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00051  Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
Disease
H01376  Acrofacial dysostosis
Drug target
Brequinar sodium: D03154
Emvododstat: D11890
Leflunomide: D00749<JP/US>
Teriflunomide: D10172<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    1723 (DHODH)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.2  dihydroorotate dehydrogenase (quinone)
     1723 (DHODH)
SSDB
Motif
Pfam: DHO_dh FMN_dh Trp_syntA NMO
Other DBs
NCBI-GeneID: 1723
NCBI-ProteinID: NP_001352
OMIM: 126064
HGNC: 2867
Ensembl: ENSG00000102967
Pharos: Q02127(Tclin)
UniProt: Q02127
Structure
Position
16:72008744..72027659
AA seq 395 aa
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
NT seq 1188 nt   +upstreamnt  +downstreamnt
atggcgtggagacacctgaaaaagcgggcccaggatgctgtgatcatcctggggggagga
ggacttctcttcgcctcctacctgatggccacgggagatgagcgtttctatgctgaacac
ctgatgccgactctgcaggggctgctggacccggagtcagcccacagactggctgttcgc
ttcacctccctggggctccttccacgggccagatttcaagactctgacatgctggaagtg
agagttctgggccataaattccgaaatccagtaggaattgctgcaggatttgacaagcat
ggggaagccgtggacggactttataagatgggctttggttttgttgagataggaagtgtg
actccaaaacctcaggaaggaaaccctagacccagagtcttccgcctccctgaggaccaa
gctgtcattaacaggtatggatttaacagtcacgggctttcagtggtggaacacaggtta
cgggccagacagcagaagcaggccaagctcacagaagatggactgcctctgggggtcaac
ttggggaagaacaagacctcagtggacgccgcggaggactacgcagaaggggtgcgcgta
ctgggccccctggccgactacctggtggtgaatgtgtccagccccaacactgccgggctg
cggagccttcagggaaaggccgagctgcgccgcctgctgaccaaggtgctgcaggagagg
gatggcttgcggagagtgcacaggccggcagtcctggtgaagatcgctcctgacctcacc
agccaggataaggaggacattgccagtgtggtcaaagagttgggcatcgatgggctgatt
gttacgaacaccaccgtgagtcgccctgcgggcctccagggtgccctgcgctctgaaaca
ggagggctgagtgggaagcccctccgggatttatcaactcaaaccattcgggagatgtat
gcactcacccaaggccgagttcccataattggggttggtggtgtgagcagcgggcaggac
gcgctggagaagatccgggcaggggcctccctggtgcagctgtacacggccctcaccttc
tgggggccacccgttgtgggcaaagtcaagcgggaactggaggcccttctgaaagagcag
ggctttggcggagtcacagatgccattggagcagatcatcggaggtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (4)   
   KEGG DRUG (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (26)   
   RefSeq(nuc) (4)   
   GenBank (11)   
   EMBL (11)   
3D Structure (79)   
   PDB (79)   
Protein domain (4)   
   Pfam (4)   
All databases (144)   

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