KEGG   Homo sapiens (human): 1734
Entry
1734              CDS       T01001                                 
Symbol
DIO2, 5DII, D2, DIOII, SELENOY, SelY, TXDI2
Name
(RefSeq) iodothyronine deiodinase 2
  KO
K17904  type II thyroxine 5'-deiodinase [EC:1.21.99.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04919  Thyroid hormone signaling pathway
Drug target
Propylthiouracil: D00562<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    1734 (DIO2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.21  Catalysing the reaction X-H + Y-H = X-Y
   1.21.99  With unknown physiological acceptors
    1.21.99.4  thyroxine 5'-deiodinase
     1734 (DIO2)
SSDB
Motif
Pfam: T4_deiodinase AhpC-TSA Redoxin
Other DBs
NCBI-GeneID: 1734
NCBI-ProteinID: NP_054644
OMIM: 601413
HGNC: 2884
Ensembl: ENSG00000211448
UniProt: Q92813
Position
14:complement(80197526..80231057)
AA seq 273 aa
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
NT seq 822 nt   +upstreamnt  +downstreamnt
atgggcatcctcagcgtagacttgctgatcacactgcaaattctgccagtttttttctcc
aactgcctcttcctggctctctatgactcggtcattctgctcaagcacgtggtgctgctg
ttgagccgctccaagtccactcgcggagagtggcggcgcatgctgacctcagagggactg
cgctgcgtctggaagagcttcctcctcgatgcctacaaacaggtgaaattgggtgaggat
gcccccaattccagtgtggtgcatgtctccagtacagaaggaggtgacaacagtggcaat
ggtacccaggagaagatagctgagggagccacatgccaccttcttgactttgccagccct
gagcgcccactagtggtcaactttggctcagccacttgacctcctttcacgagccagctg
ccagccttccgcaaactggtggaagagttctcctcagtggctgacttcctgctggtctac
attgatgaggctcatccatcagatggctgggcgataccgggggactcctctttgtctttt
gaggtgaagaagcaccagaaccaggaagatcgatgtgcagcagcccagcagcttctggag
cgtttctccttgccgccccagtgccgagttgtggctgaccgcatggacaataacgccaac
atagcttacggggtagcctttgaacgtgtgtgcattgtgcagagacagaaaattgcttat
ctgggaggaaagggccccttctcctacaaccttcaagaagtccggcattggctggagaag
aatttcagcaagagatgaaagaaaactagattagctggttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (48)   
   RefSeq(nuc) (8)   
   GenBank (20)   
   EMBL (20)   
Protein domain (3)   
   Pfam (3)   
All databases (70)   

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