KEGG   Homo sapiens (human): 1803
Entry
1803              CDS       T01001                                 

Gene name
DPP4, ADABP, ADCP2, CD26, DPPIV, TP103
Definition
(RefSeq) dipeptidyl peptidase 4
  KO
K01278  dipeptidyl-peptidase 4 [EC:3.4.14.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04974  Protein digestion and absorption
Drug target
Alogliptin: D06553<JP/US>
Anagliptin: D09780<JP>
Carmegliptin (DG01281): D08631 D09326
Denagliptin tosylate: D06578
Dutogliptin (DG01282): D09333 D09334
Evogliptin: D11023
Gemigliptin: D10502
Gosogliptin: D09625
Linagliptin: D09566<JP/US>
Omarigliptin: D10317<JP>
Saxagliptin (DG00119): D08996 D09753<JP> D10262<US>
Sitagliptin (DG00118): D06645<JP/US> D08516
Teneligliptin (DG01283): D08616 D09756<JP> D11968
Trelagliptin (DG01284): D10178 D10179<JP>
Vildagliptin: D07080<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04974 Protein digestion and absorption
    1803 (DPP4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1803 (DPP4)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1803 (DPP4)
   04090 CD molecules [BR:hsa04090]
    1803 (DPP4)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.14  Dipeptidyl-peptidases and tripeptidyl-peptidases
    3.4.14.5  dipeptidyl-peptidase IV
     1803 (DPP4)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S9: prolyl oligopeptidase family
   1803 (DPP4)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   1803 (DPP4)
  Exosomal proteins of epithelial cells
   1803 (DPP4)
  Exosomal proteins of colorectal cancer cells
   1803 (DPP4)
CD molecules [BR:hsa04090]
 Proteins
  1803 (DPP4)
SSDB
Motif
Pfam: DPPIV_N Peptidase_S9 DPPIV_rep DLH LIP Abhydrolase_6 Abhydrolase_3 Abhydrolase_2 Peptidase_S15
Other DBs
NCBI-GeneID: 1803
NCBI-ProteinID: NP_001926
OMIM: 102720
HGNC: 3009
Ensembl: ENSG00000197635
Vega: OTTHUMG00000132056
Pharos: P27487(Tclin)
UniProt: P27487
Structure
PDB: 

Position
2q24.2
AA seq 766 aa
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
NT seq 2301 nt   +upstreamnt  +downstreamnt
atgaagacaccgtggaaggttcttctgggactgctgggtgctgctgcgcttgtcaccatc
atcaccgtgcccgtggttctgctgaacaaaggcacagatgatgctacagctgacagtcgc
aaaacttacactctaactgattacttaaaaaatacttatagactgaagttatactcctta
agatggatttcagatcatgaatatctctacaaacaagaaaataatatcttggtattcaat
gctgaatatggaaacagctcagttttcttggagaacagtacatttgatgagtttggacat
tctatcaatgattattcaatatctcctgatgggcagtttattctcttagaatacaactac
gtgaagcaatggaggcattcctacacagcttcatatgacatttatgatttaaataaaagg
cagctgattacagaagagaggattccaaacaacacacagtgggtcacatggtcaccagtg
ggtcataaattggcatatgtttggaacaatgacatttatgttaaaattgaaccaaattta
ccaagttacagaatcacatggacggggaaagaagatataatatataatggaataactgac
tgggtttatgaagaggaagtcttcagtgcctactctgctctgtggtggtctccaaacggc
acttttttagcatatgcccaatttaacgacacagaagtcccacttattgaatactccttc
tactctgatgagtcactgcagtacccaaagactgtacgggttccatatccaaaggcagga
gctgtgaatccaactgtaaagttctttgttgtaaatacagactctctcagctcagtcacc
aatgcaacttccatacaaatcactgctcctgcttctatgttgataggggatcactacttg
tgtgatgtgacatgggcaacacaagaaagaatttctttgcagtggctcaggaggattcag
aactattcggtcatggatatttgtgactatgatgaatccagtggaagatggaactgctta
gtggcacggcaacacattgaaatgagtactactggctgggttggaagatttaggccttca
gaacctcattttacccttgatggtaatagcttctacaagatcatcagcaatgaagaaggt
tacagacacatttgctatttccaaatagataaaaaagactgcacatttattacaaaaggc
acctgggaagtcatcgggatagaagctctaaccagtgattatctatactacattagtaat
gaatataaaggaatgccaggaggaaggaatctttataaaatccaacttagtgactataca
aaagtgacatgcctcagttgtgagctgaatccggaaaggtgtcagtactattctgtgtca
ttcagtaaagaggcgaagtattatcagctgagatgttccggtcctggtctgcccctctat
actctacacagcagcgtgaatgataaagggctgagagtcctggaagacaattcagctttg
gataaaatgctgcagaatgtccagatgccctccaaaaaactggacttcattattttgaat
gaaacaaaattttggtatcagatgatcttgcctcctcattttgataaatccaagaaatat
cctctactattagatgtgtatgcaggcccatgtagtcaaaaagcagacactgtcttcaga
ctgaactgggccacttaccttgcaagcacagaaaacattatagtagctagctttgatggc
agaggaagtggttaccaaggagataagatcatgcatgcaatcaacagaagactgggaaca
tttgaagttgaagatcaaattgaagcagccagacaattttcaaaaatgggatttgtggac
aacaaacgaattgcaatttggggctggtcatatggagggtacgtaacctcaatggtcctg
ggatcgggaagtggcgtgttcaagtgtggaatagccgtggcgcctgtatcccggtgggag
tactatgactcagtgtacacagaacgttacatgggtctcccaactccagaagacaacctt
gaccattacagaaattcaacagtcatgagcagagctgaaaattttaaacaagttgagtac
ctccttattcatggaacagcagatgataacgttcactttcagcagtcagctcagatctcc
aaagccctggtcgatgttggagtggatttccaggcaatgtggtatactgatgaagaccat
ggaatagctagcagcacagcacaccaacatatatatacccacatgagccacttcataaaa
caatgtttctctttaccttag

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (23)   
   KEGG DRUG (23)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (30)   
   RefSeq(nuc) (8)   
   GenBank (11)   
   EMBL (11)   
Protein domain (9)   
   Pfam (9)   
All databases (93)   

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