KEGG   Homo sapiens (human): 2017
Entry
2017              CDS       T01001                                 
Symbol
CTTN, EMS1
Name
(RefSeq) cortactin
  KO
K06106  cortactin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04530  Tight junction
hsa05100  Bacterial invasion of epithelial cells
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05205  Proteoglycans in cancer
Network
nt06135  Cytoskeletal regulation (viruses and bacteria)
  Element
N01078  EGF-EGFR-Actin signaling pathway
N01079  Shigella IpaC to Actin signaling pathway
N01287  Tight junction-Actin signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    2017 (CTTN)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    2017 (CTTN)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    2017 (CTTN)
   05131 Shigellosis
    2017 (CTTN)
   05100 Bacterial invasion of epithelial cells
    2017 (CTTN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2017 (CTTN)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    2017 (CTTN)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Others
    2017 (CTTN)
 Others
  Actin-binding proteins
   Nucleation-promoting factors (NPFs)
    2017 (CTTN)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     2017 (CTTN)
SSDB
Motif
Pfam: HS1_rep SH3_9 SH3_1 SH3_2 MCU
Other DBs
NCBI-GeneID: 2017
NCBI-ProteinID: NP_005222
OMIM: 164765
HGNC: 3338
Ensembl: ENSG00000085733
Pharos: Q14247(Tbio)
UniProt: Q14247 Q53HG7
Structure
Position
11:70398529..70436575
AA seq 550 aa
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT
DRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ
DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE
KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV
YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP
AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL
FPANYVELRQ
NT seq 1653 nt   +upstreamnt  +downstreamnt
atgtggaaagcttcagcaggccacgctgtgtccatcgcccaggatgacgcgggggccgat
gactgggagaccgaccctgattttgtgaatgatgtgagtgagaaggagcaaagatggggt
gccaagacggtgcagggctccgggcaccaggagcatatcaacatacacaagctgagggag
aatgtctttcaagagcatcagacccttaaggagaaggaacttgaaacaggaccaaaagct
tcccatggctatggagggaaatttggtgtggaacaagaccgaatggataagtcagctgtc
ggccacgaatatcagtcgaaactttccaagcactgctcgcaggtggactcggtccgtggc
ttcggaggcaagtttggtgtccagatggacagagttgatcagtctgctgtaggctttgaa
taccaggggaagactgagaagcatgcctcccagaaagactactccagtggttttggcggc
aagtatggcgtgcaggccgaccgagtagacaagagcgcggtgggcttcgactaccagggc
aagacggagaagcacgagtcacagagagattactccaaaggtttcggcggcaaatacggt
atcgacaaggacaaagtggataagagcgccgttggctttgagtatcaaggcaaaacggag
aagcacgagtcccagaaagactatgtgaaagggtttggaggaaaatttggtgtgcagaca
gacagacaagacaaatgtgcccttggctgggatcaccaggagaaattgcagctgcatgaa
tcccaaaaagattataagactggttttggaggcaaattcggtgttcagtcggagaggcag
gactccgctgctgtggggtttgattacaaggagaagctggccaagcacgagtcccagcaa
gactactccaaaggattcggcgggaagtatggggtgcagaaggatcggatggataagaat
gcgtcaacctttgaggatgtcacccaggtgtcctctgcctaccagaagacagtacctgtc
gaagctgtgaccagcaaaacaagtaacatcagagctaactttgaaaacctcgctaaggag
aaagagcaggaggacaggcggaaggcggaggcggagagagcccagcggatggccaaggag
cggcaggagcaggaagaggccaggaggaagctggaggagcaagccagagccaaaacgcaa
acgccccctgtgtcgcccgcacctcagccaaccgaggagaggctgccctcgagccccgtc
tatgaggatgcggcttccttcaaggcagagctgagctacagaggccctgtgagtgggacg
gagccggagcccgtgtacagcatggaggccgctgactaccgagaggccagcagccagcag
ggcctggcctatgccacagaggctgtctatgaaagcgcagaggccccgggccactatccc
gcagaggacagcacctacgatgagtacgagaacgatctggggatcacagccgtcgccctg
tacgactaccaggctgcgggcgatgatgagatctcatttgaccctgatgacatcatcacc
aacatcgagatgattgacgacggctggtggcgcggggtgtgcaagggccggtacgggctc
ttcccagccaactatgtggagctgcggcagtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
   PHAROS (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (32)   
   RefSeq(nuc) (6)   
   GenBank (13)   
   EMBL (13)   
3D Structure (2)   
   PDB (2)   
Protein domain (5)   
   Pfam (5)   
All databases (82)   

Download RDF
KEGG   Homo sapiens (human): 3059
Entry
3059              CDS       T01001                                 
Symbol
HCLS1, CTTNL, HS1, lckBP1, p75
Name
(RefSeq) hematopoietic cell-specific Lyn substrate 1
  KO
K06106  cortactin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04530  Tight junction
hsa05100  Bacterial invasion of epithelial cells
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    3059 (HCLS1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    3059 (HCLS1)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    3059 (HCLS1)
   05131 Shigellosis
    3059 (HCLS1)
   05100 Bacterial invasion of epithelial cells
    3059 (HCLS1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3059 (HCLS1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    3059 (HCLS1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Others
    3059 (HCLS1)
 Others
  Actin-binding proteins
   Nucleation-promoting factors (NPFs)
    3059 (HCLS1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     3059 (HCLS1)
SSDB
Motif
Pfam: HS1_rep SH3_1 SH3_9 SH3_2 SPESP1 DUF4100 Med3
Other DBs
NCBI-GeneID: 3059
NCBI-ProteinID: NP_005326
OMIM: 601306
HGNC: 4844
Ensembl: ENSG00000180353
Pharos: P14317(Tbio)
UniProt: P14317
Position
3:complement(121631399..121660903)
AA seq 486 aa
MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE
TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA
KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
GAGAGAVALGISAVAVYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
YVKLLE
NT seq 1461 nt   +upstreamnt  +downstreamnt
atgtggaagtctgtagtgggccatgatgtgtctgtttccgtggagacccagggtgatgat
tgggacacagatcctgactttgtgaatgacatctctgaaaaggagcaacgatggggagcc
aagaccatcgaggggtctggacgcacagaacacatcaacatccaccagctgaggaacaaa
gtatcagaggagcatgatgttctcaggaagaaagagatggagtcagggcccaaagcatcc
catggctatggaggtcggtttggagtagaaagagaccgaatggacaagagtgcagtgggc
catgagtatgttgccgaggtggagaagcactcttctcagacggatgctgccaaaggcttt
gggggcaagtacggagttgagagggacagggcagacaagtcagcagtcggctttgattat
aaaggagaagtggagaagcacacatctcagaaagattactctcgtggctttggtggccgg
tacggggtggagaaggataaatgggacaaagcagctctgggatatgactacaagggagag
acggagaaacacgagtcccagagagattatgccaagggctttggtggccagtatggaatc
cagaaggaccgagtggataagagcgctgtcggcttcaatgaaatggaggccccgaccaca
gcttataagaagacgacgcccatagaagccgcttctagtggtacccgtgggctgaaggcg
aaatttgagtccatggctgaggagaagaggaagcgagaggaagaggagaaggcacagcag
gtggccaggaggcaacaggagcgaaaggctgtgacaaagaggagccctgaggctccacag
ccagtgatagctatggaagagccagcagtaccggccccactgcccaagaaaatctcctca
gaggcctggcctccagttgggactcctccatcatcagagtctgagcctgtgagaaccagc
agggaacacccagtgcccttgctgcccattaggcagactctcccggaggacaatgaggag
cccccagctctgccccctaggactctggaaggcctccaggtggaggaagagccagtgtac
gaagcagagcctgagcctgagcccgagcctgagcccgagcctgagaatgactatgaggac
gttgaggagatggacaggcatgagcaggaggatgaaccagagggggactatgaggaggtg
ctcgagcctgaagattcttctttttcttctgctctggctggatcatcaggctgcccggct
ggggctggggctggggctgtggctctggggatctcagctgtggctgtatatgattaccaa
ggagagggaagtgatgagctttcctttgatccggacgacgtaatcactgacattgagatg
gtggacgagggctggtggcggggacgttgccatggccactttggactcttccctgcaaat
tatgtcaagcttctggagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
   PHAROS (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (36)   
   RefSeq(nuc) (2)   
   GenBank (17)   
   EMBL (17)   
Protein domain (7)   
   Pfam (7)   
All databases (89)   

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