KEGG   Homo sapiens (human): 2041
Entry
2041              CDS       T01001                                 

Gene name
EPHA1, EPH, EPHT, EPHT1
Definition
(RefSeq) EPH receptor A1
  KO
K05102  Eph receptor A1 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Drug target
Sitravatinib (DG03045): D11140 D11541
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    2041 (EPHA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2041 (EPHA1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2041 (EPHA1)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  EPH family [OT]
   2041 (EPHA1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Ephrin_lbd Pkinase fn3 SAM_1 EphA2_TM SAM_2 Pur_ac_phosph_N Ephrin_rec_like Kdo Tissue_fac
Other DBs
NCBI-GeneID: 2041
NCBI-ProteinID: NP_005223
OMIM: 179610
HGNC: 3385
Ensembl: ENSG00000146904
Vega: OTTHUMG00000155894
Pharos: P21709(Tchem)
UniProt: P21709
Structure
PDB: 
3HIL 3KKA 2K1L 2K1K

Position
7q34-q35
AA seq 976 aa
MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNG
TPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKE
TFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRG
LYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPR
PSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQ
STAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGG
RQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVE
AQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLT
YELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVS
RGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYV
DLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKD
TSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQ
LVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGT
YETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE
DGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRM
TLRLPSLSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITL
PGHQKRILCSIQGFKD
NT seq 2931 nt   +upstreamnt  +downstreamnt
atggagcggcgctggcccctggggctagggctggtgctgctgctctgcgccccgctgccc
ccgggggcgcgcgccaaggaagttactctgatggacacaagcaaggcacagggagagctg
ggctggctgctggatcccccaaaagatgggtggagtgaacagcaacagatactgaatggg
acacccctgtacatgtaccaggactgcccaatgcaaggacgcagagacactgaccactgg
cttcgctccaattggatctaccgcggggaggaggcttcccgcgtccacgtggagctgcag
ttcaccgtgcgggactgcaagagtttccctgggggagccgggcctctgggctgcaaggag
accttcaaccttctgtacatggagagtgaccaggatgtgggcattcagctccgacggccc
ttgttccagaaggtaaccacggtggctgcagaccagagcttcaccattcgagaccttgtg
tctggctccgtgaagctgaatgtggagcgctgctctctgggccgcctgacccgccgtggc
ctctacctcgctttccacaacccgggtgcctgtgtggccctggtgtctgtccgggtcttc
taccagcgctgtcctgagaccctgaatggcttggcccaattcccagacactctgcctggc
cccgctgggttggtggaagtggcggggacctgcttgccccacgcgcgggccagccccagg
ccctcaggtgcaccccgcatgcactgcagccctgatggcgagtggctggtgcctgtagga
cggtgccactgtgagcctggctatgaggaaggtggcagtggcgaagcatgtgttgcctgc
cctagcggctcctaccggatggacatggacacaccccattgtctcacgtgcccccagcag
agcactgctgagtctgagggggccaccatctgtacctgtgagagcggccattacagagct
cccggggagggcccccaggtggcatgcacaggtcccccctcggccccccgaaacctgagc
ttctctgcctcagggactcagctctccctgcgttgggaacccccagcagatacgggggga
cgccaggatgtcagatacagtgtgaggtgttcccagtgtcagggcacagcacaggacggg
gggccctgccagccctgtggggtgggcgtgcacttctcgccgggggcccgggggctcacc
acacctgcagtgcatgtcaatggccttgaaccttatgccaactacacctttaatgtggaa
gcccaaaatggagtgtcagggctgggcagctctggccatgccagcacctcagtcagcatc
agcatggggcatgcagagtcactgtcaggcctgtctctgagactggtgaagaaagaaccg
aggcaactagagctgacctgggcggggtcccggccccgaagccctggggcgaacctgacc
tatgagctgcacgtgctgaaccaggatgaagaacggtaccagatggttctagaacccagg
gtcttgctgacagagctgcagcctgacaccacatacatcgtcagagtccgaatgctgacc
ccactgggtcctggccctttctcccctgatcatgagtttcggaccagcccaccagtgtcc
aggggcctgactggaggagagattgtagccgtcatctttgggctgctgcttggtgcagcc
ttgctgcttgggattctcgttttccggtccaggagagcccagcggcagaggcagcagagg
cagcgtgaccgcgccaccgatgtggatcgagaggacaagctgtggctgaagccttatgtg
gacctccaggcatacgaggaccctgcacagggagccctggactttacccgggagcttgat
ccagcgtggctgatggtggacactgtcataggagaaggagagtttggggaagtgtatcga
gggaccctgaggctccccagccaggactgcaagactgtggccattaagaccttaaaagac
acatccccaggtggccagtggtggaacttccttcgagaggcaactatcatgggccagttt
agccacccgcatattctgcatctggaaggcgtcgtcacaaagcgaaagccgatcatgatc
atcacagaatttatggagaatggagccctggatgccttcctgagggagcgggaggaccag
ctggtccctgggcagctagtggccatgctgcagggcatagcatctggcatgaactacctc
agtaatcacaattatgtccaccgggacctggctgccagaaacatcttggtgaatcaaaac
ctgtgctgcaaggtgtctgactttggcctgactcgcctcctggatgactttgatggcaca
tacgaaacccagggaggaaagatccctatccgttggacagcccctgaagccattgcccat
cggatcttcaccacagccagcgatgtgtggagctttgggattgtgatgtgggaggtgctg
agctttggggacaagccttatggggagatgagcaatcaggaggttatgaagagcattgag
gatgggtaccggttgccccctcctgtggactgccctgcccctctgtatgagctcatgaag
aactgctgggcatatgaccgtgcccgccggccacacttccagaagcttcaggcacatctg
gagcaactgcttgccaacccccactccctgcggaccattgccaactttgaccccaggatg
actcttcgcctgcccagcctgagtggctcagatgggatcccatatcgaaccgtctctgag
tggctcgagtccatacgcatgaaacgctacatcctgcacttccactcggctgggctggac
accatggagtgtgtgctggagctgaccgctgaggacctgacgcagatgggaatcacactg
cccgggcaccagaagcgcattctttgcagtattcagggattcaaggactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (35)   
   RefSeq(nuc) (3)   
   GenBank (16)   
   EMBL (16)   
Protein domain (11)   
   Pfam (11)   
All databases (83)   

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