KEGG   Homo sapiens (human): 2046
Entry
2046              CDS       T01001                                 

Gene name
EPHA8, EEK, EK3, HEK3
Definition
(RefSeq) EPH receptor A8
  KO
K05109  Eph receptor A8 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    2046 (EPHA8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2046 (EPHA8)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2046 (EPHA8)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  EPH family [OT]
   2046 (EPHA8)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Ephrin_lbd Pkinase fn3 SAM_1 SAM_2 EphA2_TM Pur_ac_phosph_N fn3_2 Kdo Ephrin_rec_like SusE Interfer-bind
Other DBs
NCBI-GeneID: 2046
NCBI-ProteinID: NP_065387
OMIM: 176945
HGNC: 3391
Ensembl: ENSG00000070886
Vega: OTTHUMG00000002892
Pharos: P29322(Tchem)
UniProt: P29322
Structure
PDB: 
3KUL 1X5L 1UCV

Position
1p36.12
AA seq 1005 aa
MAPARGRLPPALWVVTAAAAAATCVSAARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEV
DESFQPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKE
TFNLYYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRG
FYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEER
DTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSA
APAAQACHCDLSYYRAALDPPSSACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDI
TYNAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSD
LSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEK
DKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDT
RTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHHP
PGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQR
DVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS
LDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFG
LSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYW
NMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPE
SLRATATVSRCPPPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLG
MVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQLTSTQGPRRHL
NT seq 3018 nt   +upstreamnt  +downstreamnt
atggcccccgcccggggccgcctgccccctgcgctctgggtcgtcacggccgcggcggcg
gcggccacctgcgtgtccgcggcgcgcggcgaagtgaatttgctggacacgtcgaccatc
cacggggactggggctggctcacgtatccggctcatgggtgggactccatcaacgaggtg
gacgagtccttccagcccatccacacgtaccaggtttgcaacgtcatgagccccaaccag
aacaactggctgcgcacgagctgggtcccccgagacggcgcccggcgcgtctatgctgag
atcaagtttaccctgcgcgactgcaacagcatgcctggtgtgctgggcacctgcaaggag
accttcaacctctactacctggagtcggaccgcgacctgggggccagcacacaagaaagc
cagttcctcaaaatcgacaccattgcggccgacgagagcttcacaggtgccgaccttggt
gtgcggcgtctcaagctcaacacggaggtgcgcagtgtgggtcccctcagcaagcgcggc
ttctacctggccttccaggacataggtgcctgcctggccatcctctctctccgcatctac
tataagaagtgccctgccatggtgcgcaatctggctgccttctcggaggcagtgacgggg
gccgactcgtcctcactggtggaggtgaggggccagtgcgtgcggcactcagaggagcgg
gacacacccaagatgtactgcagcgcggagggcgagtggctcgtgcccatcggcaaatgc
gtgtgcagtgccggctacgaggagcggcgggatgcctgtgtggcctgtgagctgggcttc
tacaagtcagcccctggggaccagctgtgtgcccgctgccctccccacagccactccgca
gctccagccgcccaagcctgccactgtgacctcagctactaccgtgcagccctggacccg
ccgtcctcagcctgcacccggccaccctcggcaccagtgaacctgatctccagtgtgaat
gggacatcagtgactctggagtgggcccctcccctggacccaggtggccgcagtgacatc
acctacaatgccgtgtgccgccgctgcccctgggcactgagccgctgcgaggcatgtggg
agcggcacccgctttgtgccccagcagacaagcctggtgcaggccagcctgctggtggcc
aacctgctggcccacatgaactactccttctggatcgaggccgtcaatggcgtgtccgac
ctgagccccgagccccgccgggccgctgtggtcaacatcaccacgaaccaggcagccccg
tcccaggtggtggtgatccgtcaagagcgggcggggcagaccagcgtctcgctgctgtgg
caggagcccgagcagccgaacggcatcatcctggagtatgagatcaagtactacgagaag
gacaaggagatgcagagctactccaccctcaaggccgtcaccaccagagccaccgtctcc
ggcctcaagccgggcacccgctacgtgttccaggtccgagcccgcacctcagcaggctgt
ggccgcttcagccaggccatggaggtggagaccgggaaaccccggccccgctatgacacc
aggaccattgtctggatctgcctgacgctcatcacgggcctggtggtgcttctgctcctg
ctcatctgcaagaagaggcactgtggctacagcaaggccttccaggactcggacgaggag
aagatgcactatcagaatggacaggcacccccacctgtcttcctgcctctgcatcacccc
ccgggaaagctcccagagccccagttctatgcggaaccccacacctacgaggagccaggc
cgggcgggccgcagtttcactcgggagatcgaggcctctaggatccacatcgagaaaatc
atcggctctggagactccggggaagtctgctacgggaggctgcgggtgccagggcagcgg
gatgtgcccgtggccatcaaggccctcaaagccggctacacggagagacagaggcgggac
ttcctgagcgaggcgtccatcatggggcaattcgaccatcccaacatcatccgcctcgag
ggtgtcgtcacccgtggccgcctggcaatgattgtgactgagtacatggagaacggctct
ctggacaccttcctgaggacccacgacgggcagttcaccatcatgcagctggtgggcatg
ctgagaggagtgggtgccggcatgcgctacctctcagacctgggctatgtccaccgagac
ctggccgcccgcaacgtcctggttgacagcaacctggtctgcaaggtgtctgacttcggg
ctctcacgggtgctggaggacgacccggatgctgcctacaccaccacgggcgggaagatc
cccatccgctggacggccccagaggccatcgccttccgcaccttctcctcggccagcgac
gtgtggagcttcggcgtggtcatgtgggaggtgctggcctatggggagcggccctactgg
aacatgaccaaccgggatgtcatcagctctgtggaggaggggtaccgcctgcccgcaccc
atgggctgcccccacgccctgcaccagctcatgctcgactgttggcacaaggaccgggcg
cagcggcctcgcttctcccagattgtcagtgtcctcgatgcgctcatccgcagccctgag
agtctcagggccaccgccacagtcagcaggtgcccaccccctgccttcgtccggagctgc
tttgacctccgagggggcagcggtggcggtgggggcctcaccgtgggggactggctggac
tccatccgcatgggccggtaccgagaccacttcgctgcgggcggatactcctctctgggc
atggtgctacgcatgaacgcccaggacgtgcgcgccctgggcatcaccctcatgggccac
cagaagaagatcctgggcagcattcagaccatgcgggcccagctgaccagcacccagggg
ccccgccggcacctctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (17)   
   RefSeq(nuc) (9)   
   GenBank (4)   
   EMBL (4)   
Protein domain (13)   
   Pfam (13)   
All databases (70)   

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