KEGG T01001: 2053

Homo sapiens (human): 2053

Entry

2053 CDS T01001

Gene name

EPHX2, ABHD20, CEH, SEH

Definition

(RefSeq) epoxide hydrolase 2

K08726

soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]

Organism

hsa Homo sapiens (human)

Pathway

hsa00590

Arachidonic acid metabolism

hsa01100

Metabolic pathways

hsa04146

Peroxisome

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    2053 (EPHX2)
09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    2053 (EPHX2)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    2053 (EPHX2)
   01002 Peptidases and inhibitors [BR:hsa01002]
    2053 (EPHX2)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.76  lipid-phosphate phosphatase
     2053 (EPHX2)
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.10  soluble epoxide hydrolase
     2053 (EPHX2)
Protein phosphatases and associated proteins [BR:hsa01009]
HAD phosphatases
  Other HAD phosphatases
   2053 (EPHX2)
Peptidases and inhibitors [BR:hsa01002]
Serine peptidases
  Family S33
   2053 (EPHX2)

SSDB

Motif

Pfam:

Abhydrolase_1 Abhydrolase_6 Hydrolase_4 HAD_2 Hydrolase Hydrolase_like E2_bind Resolvase Ndr Abhydrolase_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P34913(Tchem)

UniProt:

P34913

Structure

PDB:

5MWA 5AM2 5AI0 5AK4 5ALV 5AI9 4X6X 5AKI 5ALI 5AI8 5AM4 5ALU 5AM0 5AIC 5ALH 5ALY 5AKK 5AI4 5ALE 5AIB 3I28 4JNC 3ANS 6I5G 6HGV 5ALM 5ALN 5ALO 5AKL 5AHX 3WKA 5AKJ 4Y2P 5ALP 4C4Z 5AKX 5ALJ 5AKH 4X6Y 3WK6 3WK4 5ALT 5AM1 5AK6 4Y2J 6HGX 4C4X 5AKY 5AKZ 5AM3 5ALL 5ALW 3WK9 3WKB 3WKC 3WK7 3WK8 5AK5 5ALX 6FR2 5AM5 5ALD 5AKE 5AIA 5AK3 5AI5 5ALZ 5AI6 4Y2S 4Y2Y 1ZD3 5ALF 5ALK 5FP0 1VJ5 5ALG 4Y2Q 4Y2T 4Y2V 3ANT 6HGW 4C4Y 4Y2R 3I1Y 3WKD 4Y2X 5AKG 4HAI 5ALS 6I5E 5ALR 3PDC 1ZD5 1S8O 1ZD4 4Y2U 3WKE 3WK5 5ALQ 3KOO 4OD0 4J03 4OCZ 6AUM 3OTQ 1ZD2

Position

8p21.2-p21.1

AA seq 555 aa
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM

NT seq 1668 nt +upstreamnt +downstreamnt
atgacgctgcgcgcggccgtcttcgaccttgacggggtgctggcgctgccagcggtgttc
ggcgtcctcggccgcacggaggaggccctggcgctgcccagaggacttctgaatgatgct
ttccagaaagggggaccagagggtgccactacccggcttatgaaaggagagatcacactt
tcccagtggataccactcatggaagaaaactgcaggaagtgctccgagaccgctaaagtc
tgcctccccaagaatttctccataaaagaaatctttgacaaggcgatttcagccagaaag
atcaaccgccccatgctccaggcagctctcatgctcaggaagaaaggattcactactgcc
atcctcaccaacacctggctggacgaccgtgctgagagagatggcctggcccagctgatg
tgtgagctgaagatgcactttgacttcctgatagagtcgtgtcaggtgggaatggtcaaa
cctgaacctcagatctacaagtttctgctggacaccctgaaggccagccccagtgaggtc
gtttttttggatgacatcggggctaatctgaagccagcccgtgacttgggaatggtcacc
atcctggtccaggacactgacacggccctgaaagaactggagaaagtgaccggaatccag
cttctcaataccccggcccctctgccgacctcttgcaatccaagtgacatgagccatggg
tacgtgacagtaaagcccagggtccgtctgcattttgtggagctgggctccggccctgct
gtgtgcctctgccatggatttcccgagagttggtattcttggaggtaccagatccctgct
ctggcccaggcaggttaccgggtcctagctatggacatgaaaggctatggagagtcatct
gctcctcccgaaatagaagaatattgcatggaagtgttatgtaaggagatggtaaccttc
ctggataaactgggcctctctcaagcagtgttcattggccatgactggggtggcatgctg
gtgtggtacatggctctcttctaccccgagagagtgagggcggtggccagtttgaatact
cccttcataccagcaaatcccaacatgtcccctttggagagtatcaaagccaacccagta
tttgattaccagctctacttccaagaaccaggagtggctgaggctgaactggaacagaac
ctgagtcggactttcaaaagcctcttcagagcaagcgatgagagtgttttatccatgcat
aaagtctgtgaagcgggaggactttttgtaaatagcccagaagagcccagcctcagcagg
atggtcactgaggaggaaatccagttctatgtgcagcagttcaagaagtctggtttcaga
ggtcctctaaactggtaccgaaacatggaaaggaactggaagtgggcttgcaaaagcttg
ggacggaagatcctgattccggccctgatggtcacggcggagaaggacttcgtgctcgtt
cctcagatgtcccagcacatggaggactggattccccacctgaaaaggggacacattgag
gactgtgggcactggacacagatggacaagccaaccgaggtgaatcagatcctcattaag
tggctggattctgatgcccggaacccaccggtggtctcaaagatgtag

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