KEGG   Homo sapiens (human): 2222
Entry
2222              CDS       T01001                                 
Symbol
FDFT1, DGPT, ERG9, SQS, SQSD, SS
Name
(RefSeq) farnesyl-diphosphate farnesyltransferase 1
  KO
K00801  farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00100  Steroid biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00101  Cholesterol biosynthesis, FPP => cholesterol
Network
nt06034  Cholesterol biosynthesis
  Element
N01624  Cholesterol biosynthesis
Drug target
Lapaquistat acetate: D06609
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    2222 (FDFT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    2222 (FDFT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.21  squalene synthase
     2222 (FDFT1)
Prenyltransferases [BR:hsa01006]
 Terpene biosynthesis
  Squalene/phytoene synthase
   2222 (FDFT1)
SSDB
Motif
Pfam: SQS_PSY Octopine_DH
Other DBs
NCBI-GeneID: 2222
NCBI-ProteinID: NP_001274671
OMIM: 184420
HGNC: 3629
Ensembl: ENSG00000079459
UniProt: P37268 Q6IAX1
Structure
Position
8:11795582..11839298
AA seq 417 aa
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
NT seq 1254 nt   +upstreamnt  +downstreamnt
atggagttcgtgaaatgccttggccaccccgaagagttctacaacctggtgcgcttccgg
atcgggggcaagcggaaggtgatgcccaagatggaccaggactcgctcagcagcagcctg
aaaacttgctacaagtatctcaatcagaccagtcgcagtttcgcagctgttatccaggcg
ctggatggggaaatgcgcaacgcagtgtgcatattttatctggttctccgagctctggac
acactggaagatgacatgaccatcagtgtggaaaagaaggtcccgctgttacacaacttt
cactctttcctttaccaaccagactggcggttcatggagagcaaggagaaggatcgccag
gtgctggaggacttcccaacgatctcccttgagtttagaaatctggctgagaaataccaa
acagtgattgccgacatttgccggagaatgggcattgggatggcagagtttttggataag
catgtgacctctgaacaggagtgggacaagtactgccactatgttgctgggctggtcgga
attggcctttcccgtcttttctcagcctcagagtttgaagaccccttagttggtgaagat
acagaacgtgccaactctatgggcctgtttttgcagaaaacaaacatcatccgtgactat
ctggaagaccagcaaggaggaagagagttctggcctcaagaggtttggagcaggtatgtt
aagaagttaggggattttgctaagccggagaatattgacttggccgtgcagtgcctgaat
gaacttataaccaatgcactgcaccacatcccagatgtcatcacctacctttcgagactc
agaaaccagagtgtgtttaacttctgtgctattccacaggtgatggccattgccactttg
gctgcctgttataataaccagcaggtgttcaaaggggcagtgaagattcggaaagggcaa
gcagtgaccctgatgatggatgccaccaatatgccagctgtcaaagccatcatatatcag
tatatggaagagatttatcatagaatccccgactcagacccatcttctagcaaaacaagg
cagatcatctccaccatccggacgcagaatcttcccaactgtcagctgatttcccgaagc
cactactcccccatctacctgtcgtttgtcatgcttttggctgccctgagctggcagtac
ctgaccactctctcccaggtaacagaagactatgttcagactggagaacactga

  All links  
Disease (2)   
   OMIM (2)   
Gene (19)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (14)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (81)   
   RefSeq(nuc) (11)   
   GenBank (35)   
   EMBL (35)   
3D Structure (32)   
   PDB (32)   
Protein domain (2)   
   Pfam (2)   
All databases (150)   

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