KEGG   Homo sapiens (human): 2224
Entry
2224              CDS       T01001                                 

Gene name
FDPS, FPPS, FPS, POROK9
Definition
(RefSeq) farnesyl diphosphate synthase
  KO
K00787  farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
hsa05164  Influenza A
hsa05166  Human T-cell leukemia virus 1 infection
Module
hsa_M00367  C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
Disease
H01933  Porokeratosis
Drug target
Alendronic acid (DG00783): D00939<JP/US> D07119
Ibandronic acid (DG00785): D04486<JP/US> D08056
Incadronic acid (DG01266): D07123 D08073
Minodronic acid hydrate: D09198<JP>
Pamidronic acid (DG00782): D00941<JP/US> D07281
Risedronic acid (DG00786): D00942<US> D03234<JP/US> D08484 D11570<US>
Zoledronic acid (DG00787): D01968<JP/US> D06378 D06379 D08689 D10515
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    2224 (FDPS)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    2224 (FDPS)
   05164 Influenza A
    2224 (FDPS)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    2224 (FDPS)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.1  dimethylallyltranstransferase
     2224 (FDPS)
    2.5.1.10  (2E,6E)-farnesyl diphosphate synthase
     2224 (FDPS)
Prenyltransferases [BR:hsa01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   2224 (FDPS)
SSDB
Motif
Pfam: polyprenyl_synt
Other DBs
NCBI-GeneID: 2224
NCBI-ProteinID: NP_001129293
OMIM: 134629
HGNC: 3631
Ensembl: ENSG00000160752
Vega: OTTHUMG00000013909
Pharos: P14324(Tclin)
UniProt: P14324
Structure
PDB: 

Position
1q22
AA seq 419 aa
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
NT seq 1260 nt   +upstreamnt  +downstreamnt
atgcccctgtcccgctggttgagatctgtgggggtcttcctgctgccagccccctactgg
gcaccccgggagaggtggctgggttccctacggcggccctccctggtgcacgggtaccca
gtcctggcctggcacagtgcccgctgctggtgccaagcgtggacagaggaacctcgagcc
ctttgctcctccctcagaatgaacggagaccagaattcagatgtttatgcccaagaaaag
caggatttcgttcagcacttctcccagatcgttagggtgctgactgaggatgagatgggg
cacccagagataggagatgctattgcccggctcaaggaggtcctggagtacaatgccatt
ggaggcaagtataaccggggtttgacggtggtagtagcattccgggagctggtggagcca
aggaaacaggatgctgatagtctccagcgggcctggactgtgggctggtgtgtggaactg
ctgcaagctttcttcctggtggcagatgacatcatggattcatcccttacccgccgggga
cagatctgctggtatcagaagccgggcgtgggtttggatgccatcaatgatgctaacctc
ctggaagcatgtatctaccgcctgctgaagctctattgccgggagcagccctattacctg
aacctgatcgagctcttcctgcagagttcctatcagactgagattgggcagaccctggac
ctcctcacagccccccagggcaatgtggatcttgtcagattcactgaaaagaggtacaaa
tctattgtcaagtacaagacagctttctactccttctaccttcctatagctgcagccatg
tacatggcaggaattgatggcgagaaggagcacgccaatgccaagaagatcctgctggag
atgggggagttctttcagattcaggatgattaccttgacctctttggggaccccagtgtg
accggcaaaattggcactgacatccaggacaacaaatgcagctggctggtggttcagtgt
ctgcaacgggccactccagaacagtaccagatcctgaaggaaaattacgggcagaaggag
gctgagaaagtggcccgggtgaaggcgctatatgaggagctggatctgccagcagtgttc
ttgcaatatgaggaagacagttacagccacattatggctctcattgaacagtacgcagca
cccctgcccccagccgtctttctggggcttgcgcgcaaaatctacaagcggagaaagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (18)   
   KEGG DRUG (18)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (18)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (38)   
   RefSeq(nuc) (14)   
   GenBank (12)   
   EMBL (12)   
Protein domain (1)   
   Pfam (1)   
All databases (127)   

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