KEGG T01001: 2224

Homo sapiens (human): 2224

Entry

2224              CDS       T01001

Symbol

FDPS, FPPS, FPS, POROK9

Name

(RefSeq) farnesyl diphosphate synthase

K00787

farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]

Organism

hsa Homo sapiens (human)

Pathway

hsa00900

Terpenoid backbone biosynthesis

hsa01100

Metabolic pathways

hsa05164

Influenza A

hsa05166

Human T-cell leukemia virus 1 infection

Module

hsa_M00367

C10-C20 isoprenoid biosynthesis, non-plant eukaryotes

Disease

H01933

Porokeratosis

Drug target

Alendronic acid (DG00783):

D00939<JP/US> D07119

Ibandronic acid (DG00785):

D04486<JP/US> D08056

Incadronic acid (DG01266):

D07123 D08073

Minodronic acid hydrate:

D09198<JP>

Pamidronic acid (DG00782):

D00941<JP/US> D07281

Risedronic acid (DG00786):

D00942<US> D03234<JP/US> D08484 D11570<US>

Zoledronic acid (DG00787):

D01968<JP/US> D06378 D06379 D08689 D10515

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    2224 (FDPS)
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    2224 (FDPS)
   05164 Influenza A
    2224 (FDPS)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    2224 (FDPS)
Enzymes [BR:hsa01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.1  dimethylallyltranstransferase
     2224 (FDPS)
    2.5.1.10  (2E,6E)-farnesyl diphosphate synthase
     2224 (FDPS)
Prenyltransferases [BR:hsa01006]
Terpene biosynthesis
  Prenyl diphosphate synthase
   2224 (FDPS)

SSDB

Motif

Pfam:

polyprenyl_synt

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P14324(Tclin)

UniProt:

P14324

Structure

Position

1:155308866..155320665

AA seq 419 aa
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK

NT seq 1260 nt +upstreamnt +downstreamnt
atgcccctgtcccgctggttgagatctgtgggggtcttcctgctgccagccccctactgg
gcaccccgggagaggtggctgggttccctacggcggccctccctggtgcacgggtaccca
gtcctggcctggcacagtgcccgctgctggtgccaagcgtggacagaggaacctcgagcc
ctttgctcctccctcagaatgaacggagaccagaattcagatgtttatgcccaagaaaag
caggatttcgttcagcacttctcccagatcgttagggtgctgactgaggatgagatgggg
cacccagagataggagatgctattgcccggctcaaggaggtcctggagtacaatgccatt
ggaggcaagtataaccggggtttgacggtggtagtagcattccgggagctggtggagcca
aggaaacaggatgctgatagtctccagcgggcctggactgtgggctggtgtgtggaactg
ctgcaagctttcttcctggtggcagatgacatcatggattcatcccttacccgccgggga
cagatctgctggtatcagaagccgggcgtgggtttggatgccatcaatgatgctaacctc
ctggaagcatgtatctaccgcctgctgaagctctattgccgggagcagccctattacctg
aacctgatcgagctcttcctgcagagttcctatcagactgagattgggcagaccctggac
ctcctcacagccccccagggcaatgtggatcttgtcagattcactgaaaagaggtacaaa
tctattgtcaagtacaagacagctttctactccttctaccttcctatagctgcagccatg
tacatggcaggaattgatggcgagaaggagcacgccaatgccaagaagatcctgctggag
atgggggagttctttcagattcaggatgattaccttgacctctttggggaccccagtgtg
accggcaaaattggcactgacatccaggacaacaaatgcagctggctggtggttcagtgt
ctgcaacgggccactccagaacagtaccagatcctgaaggaaaattacgggcagaaggag
gctgagaaagtggcccgggtgaaggcgctatatgaggagctggatctgccagcagtgttc
ttgcaatatgaggaagacagttacagccacattatggctctcattgaacagtacgcagca
cccctgcccccagccgtctttctggggcttgcgcgcaaaatctacaagcggagaaagtga

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