KEGG   Homo sapiens (human): 2550
Entry
2550              CDS       T01001                                 
Symbol
GABBR1, GABABR1, GABBR1-3, GB1, GPRC3A, NEDLC
Name
(RefSeq) gamma-aminobutyric acid type B receptor subunit 1
  KO
K04615  gamma-aminobutyric acid type B receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa04915  Estrogen signaling pathway
hsa04929  GnRH secretion
hsa05032  Morphine addiction
Network
nt06544  Neuroactive ligand signaling
  Element
N01888  GABA-GABBR-GNAI/O signaling pathway
Disease
H02890  Neurodevelopmental disorder with language delay and variable cognitive abnormalities
Drug target
Aminobutyric acid: D00058<JP>
Arbaclofen (DG01354): D08861 D09791
Baclofen: D00241<JP/US>
Progabide: D05621
Valiloxybate: D12240
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    2550 (GABBR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2550 (GABBR1)
   04082 Neuroactive ligand signaling
    2550 (GABBR1)
 09150 Organismal Systems
  09152 Endocrine system
   04929 GnRH secretion
    2550 (GABBR1)
   04915 Estrogen signaling pathway
    2550 (GABBR1)
  09156 Nervous system
   04727 GABAergic synapse
    2550 (GABBR1)
  09157 Sensory system
   04742 Taste transduction
    2550 (GABBR1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2550 (GABBR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2550 (GABBR1)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  GABA
   2550 (GABBR1)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 Peripla_BP_6 Sushi UPF0242 DUF3995 DUF7525
Other DBs
NCBI-GeneID: 2550
NCBI-ProteinID: NP_001461
OMIM: 603540
HGNC: 4070
Ensembl: ENSG00000204681
UniProt: Q9UBS5 A0A1U9X7R0 Q59HG8
Structure
Position
6:complement(29602238..29633183)
AA seq 961 aa
MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVD
YEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLP
ALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSG
GWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKI
ILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKL
FEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDAR
IIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVE
GHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALA
LNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIE
QLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSS
LGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFP
FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM
DVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLL
LLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLA
IVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEK
IIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLY
K
NT seq 2886 nt   +upstreamnt  +downstreamnt
atgttgctgctgctgctactggcgccactcttcctccgccccccgggcgcgggcggggcg
cagacccccaacgccacctcagaaggttgccagatcatacacccgccctgggaagggggc
atcaggtaccggggcctgactcgggaccaggtgaaggctatcaacttcctgccagtggac
tatgagattgagtatgtgtgccggggggagcgcgaggtggtggggcccaaggtccgcaag
tgcctggccaacggctcctggacagatatggacacacccagccgctgtgtccgaatctgc
tccaagtcttatttgaccctggaaaatgggaaggttttcctgacgggtggggacctccca
gctctggacggagcccgggtggatttccggtgtgaccccgacttccatctggtgggcagc
tcccggagcatctgtagtcagggccagtggagcacccccaagccccactgccaggtgaat
cgaacgccacactcagaacggcgcgcagtgtacatcggggcactgtttcccatgagcggg
ggctggccagggggccaggcctgccagcccgcggtggagatggcgctggaggacgtgaat
agccgcagggacatcctgccggactatgagctcaagctcatccaccacgacagcaagtgt
gatccaggccaagccaccaagtacctatatgagctgctctacaacgaccctatcaagatc
atccttatgcctggctgcagctctgtctccacgctggtggctgaggctgctaggatgtgg
aacctcattgtgctttcctatggctccagctcaccagccctgtcaaaccggcagcgtttc
cccactttcttccgaacgcacccatcagccacactccacaaccctacccgcgtgaaactc
tttgaaaagtggggctggaagaagattgctaccatccagcagaccactgaggtcttcact
tcgactctggacgacctggaggaacgagtgaaggaggctggaattgagattactttccgc
cagagtttcttctcagatccagctgtgcccgtcaaaaacctgaagcgccaggatgcccga
atcatcgtgggacttttctatgagactgaagcccggaaagttttttgtgaggtgtacaag
gagcgtctctttgggaagaagtacgtctggttcctcattgggtggtatgctgacaattgg
ttcaagatctacgacccttctatcaactgcacagtggatgagatgactgaggcggtggag
ggccacatcacaactgagattgtcatgctgaatcctgccaatacccgcagcatttccaac
atgacatcccaggaatttgtggagaaactaaccaagcgactgaaaagacaccctgaggag
acaggaggcttccaggaggcaccgctggcctatgatgccatctgggccttggcactggcc
ctgaacaagacatctggaggaggcggccgttctggtgtgcgcctggaggacttcaactac
aacaaccagaccattaccgaccaaatctaccgggcaatgaactcttcgtcctttgagggt
gtctctggccatgtggtgtttgatgccagcggctctcggatggcatggacgcttatcgag
cagcttcagggtggcagctacaagaagattggctactatgacagcaccaaggatgatctt
tcctggtccaaaacagataaatggattggagggtcccccccagctgaccagaccctggtc
atcaagacattccgcttcctgtcacagaaactctttatctccgtctcagttctctccagc
ctgggcattgtcctagctgttgtctgtctgtcctttaacatctacaactcacatgtccgt
tatatccagaactcacagcccaacctgaacaacctgactgctgtgggctgctcactggct
ttagctgctgtcttccccctggggctcgatggttaccacattgggaggaaccagtttcct
ttcgtctgccaggcccgcctctggctcctgggcctgggctttagtctgggctacggttcc
atgttcaccaagatttggtgggtccacacggtcttcacaaagaaggaagaaaagaaggag
tggaggaagactctggaaccctggaagctgtatgccacagtgggcctgctggtgggcatg
gatgtcctcactctcgccatctggcagatcgtggaccctctgcaccggaccattgagaca
tttgccaaggaggaacctaaggaagatattgacgtctctattctgccccagctggagcat
tgcagctccaggaagatgaatacatggcttggcattttctatggttacaaggggctgctg
ctgctgctgggaatcttccttgcttatgagaccaagagtgtgtccactgagaagatcaat
gatcaccgggctgtgggcatggctatctacaatgtggcagtcctgtgcctcatcactgct
cctgtcaccatgattctgtccagccagcaggatgcagcctttgcctttgcctctcttgcc
atagttttctcctcctatatcactcttgttgtgctctttgtgcccaagatgcgcaggctg
atcacccgaggggaatggcagtcggaggcgcaggacaccatgaagacagggtcatcgacc
aacaacaacgaggaggagaagtcccggctgttggagaaggagaaccgtgaactggaaaag
atcattgctgagaaagaggagcgtgtctctgaactgcgccatcaactccagtctcggcag
cagctccgctcccggcgccacccaccgacacccccagaaccctctgggggcctgcccagg
ggaccccctgagccccccgaccggcttagctgtgatgggagtcgagtgcatttgctttat
aagtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (24)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (72)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (68)   
DNA sequence (111)   
   RefSeq(nuc) (71)   
   GenBank (20)   
   EMBL (20)   
3D Structure (24)   
   PDB (24)   
Protein domain (7)   
   Pfam (7)   
All databases (240)   

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