KEGG   Homo sapiens (human): 2741
Entry
2741              CDS       T01001                                 

Gene name
GLRA1, HKPX1, STHE
Definition
(RefSeq) glycine receptor alpha 1
  KO
K05193  glycine receptor alpha-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H00769  Hyperekplexia
Drug target
Strychnine nitrate: D10470
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2741 (GLRA1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2741 (GLRA1)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2741 (GLRA1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    2741 (GLRA1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glycine
   2741 (GLRA1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2741
NCBI-ProteinID: NP_001139512
OMIM: 138491
HGNC: 4326
Ensembl: ENSG00000145888
Vega: OTTHUMG00000130121
Pharos: P23415(Tclin)
UniProt: P23415
Structure
PDB: 
1VRY 1MOT

Position
5q33.1
AA seq 457 aa
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
NT seq 1374 nt   +upstreamnt  +downstreamnt
atgtacagcttcaatactcttcgactctacctttgggagaccattgtattcttcagcctt
gctgcttctaaggaggctgaagctgctcgctccgcacccaagcctatgtcaccctcggat
ttcctggataagctaatggggagaacctccggatatgatgccaggatcaggcccaatttt
aaaggtcccccagtgaacgtgagctgcaacattttcatcaacagctttggttccattgct
gagacaaccatggactatagggtcaacatcttcctgcggcagcaatggaacgacccccgc
ctggcctataatgaataccctgacgactctctggacctggacccatccatgctggactcc
atctggaaacctgacctgttctttgccaacgagaagggggcccacttccatgagatcacc
acagacaacaaattgctaaggatctcccggaatgggaatgtcctctacagcatcagaatc
accctgacactggcctgccccatggacttgaagaatttccccatggatgtccagacatgt
atcatgcaactggaaagctttggatatacgatgaatgacctcatctttgagtggcaggaa
cagggagccgtgcaggtagcagatggactaactctgccccagtttatcttgaaggaagag
aaggacttgagatactgcaccaagcactacaacacaggtaaattcacctgcattgaggcc
cggttccacctggagcggcagatgggttactacctgattcagatgtatattcccagcctg
ctcattgtcatcctctcatggatctccttctggatcaacatggatgctgcacctgctcgt
gtgggcctaggcatcaccactgtgctcaccatgaccacccagagctccggctctcgagca
tctctgcccaaggtgtcctatgtgaaagccattgacatttggatggcagtttgcctgctc
tttgtgttctcagccctattagaatatgctgccgttaactttgtgtctcggcaacataag
gagctgctccgattcaggaggaagcggagacatcacaagagccccatgttgaatctattc
caggaggatgaagctggagaaggccgctttaacttctctgcctatgggatgggcccagcc
tgtctacaggccaaggatggcatctcagtcaagggcgccaacaacagtaacaccaccaac
ccccctcctgcaccatctaagtccccagaggagatgcgaaaactcttcatccagagggcc
aagaagatcgacaaaatatcccgcattggcttccccatggccttcctcattttcaacatg
ttctactggatcatctacaagattgtccgtagagaggacgtccacaaccagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (19)   
   RefSeq(nuc) (3)   
   GenBank (8)   
   EMBL (8)   
Protein domain (2)   
   Pfam (2)   
All databases (55)   

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