KEGG   Homo sapiens (human): 2741
Entry
2741              CDS       T01001                                 
Symbol
GLRA1, HKPX1, STHE
Name
(RefSeq) glycine receptor alpha 1
  KO
K05193  glycine receptor alpha-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
Network
nt06544  Neuroactive ligand signaling
  Element
N01907  Transport of chloride, GLR
Disease
H00769  Hyperekplexia
Drug target
Strychnine nitrate: D10470
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2741 (GLRA1)
   04082 Neuroactive ligand signaling
    2741 (GLRA1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2741 (GLRA1)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2741 (GLRA1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    2741 (GLRA1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glycine
   2741 (GLRA1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2741
NCBI-ProteinID: NP_001139512
OMIM: 138491
HGNC: 4326
Ensembl: ENSG00000145888
UniProt: P23415
Structure
Position
5:complement(151822513..151924851)
AA seq 457 aa
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
NT seq 1374 nt   +upstreamnt  +downstreamnt
atgtacagcttcaatactcttcgactctacctttgggagaccattgtattcttcagcctt
gctgcttctaaggaggctgaagctgctcgctccgcacccaagcctatgtcaccctcggat
ttcctggataagctaatggggagaacctccggatatgatgccaggatcaggcccaatttt
aaaggtcccccagtgaacgtgagctgcaacattttcatcaacagctttggttccattgct
gagacaaccatggactatagggtcaacatcttcctgcggcagcaatggaacgacccccgc
ctggcctataatgaataccctgacgactctctggacctggacccatccatgctggactcc
atctggaaacctgacctgttctttgccaacgagaagggggcccacttccatgagatcacc
acagacaacaaattgctaaggatctcccggaatgggaatgtcctctacagcatcagaatc
accctgacactggcctgccccatggacttgaagaatttccccatggatgtccagacatgt
atcatgcaactggaaagctttggatatacgatgaatgacctcatctttgagtggcaggaa
cagggagccgtgcaggtagcagatggactaactctgccccagtttatcttgaaggaagag
aaggacttgagatactgcaccaagcactacaacacaggtaaattcacctgcattgaggcc
cggttccacctggagcggcagatgggttactacctgattcagatgtatattcccagcctg
ctcattgtcatcctctcatggatctccttctggatcaacatggatgctgcacctgctcgt
gtgggcctaggcatcaccactgtgctcaccatgaccacccagagctccggctctcgagca
tctctgcccaaggtgtcctatgtgaaagccattgacatttggatggcagtttgcctgctc
tttgtgttctcagccctattagaatatgctgccgttaactttgtgtctcggcaacataag
gagctgctccgattcaggaggaagcggagacatcacaagagccccatgttgaatctattc
caggaggatgaagctggagaaggccgctttaacttctctgcctatgggatgggcccagcc
tgtctacaggccaaggatggcatctcagtcaagggcgccaacaacagtaacaccaccaac
ccccctcctgcaccatctaagtccccagaggagatgcgaaaactcttcatccagagggcc
aagaagatcgacaaaatatcccgcattggcttccccatggccttcctcattttcaacatg
ttctactggatcatctacaagattgtccgtagagaggacgtccacaaccagtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (17)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (21)   
   RefSeq(nuc) (5)   
   GenBank (8)   
   EMBL (8)   
3D Structure (9)   
   PDB (9)   
Protein domain (2)   
   Pfam (2)   
All databases (58)   

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