KEGG   Homo sapiens (human): 2899Help
Entry
2899              CDS       T01001                                 

Gene name
GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a
Definition
(RefSeq) glutamate ionotropic receptor kainate type subunit 3
  KO
K05203  glutamate receptor, ionotropic kainate 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775
Tezampanel: D06656
Topiramate: D00537
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2899 (GRIK3)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2899 (GRIK3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2899 (GRIK3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2899 (GRIK3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Motif
Other DBs
NCBI-GeneID: 2899
NCBI-ProteinID: NP_000822
OMIM: 138243
HGNC: 4581
Ensembl: ENSG00000163873
Vega: OTTHUMG00000004189
Pharos: Q13003(Tclin)
UniProt: Q13003
Position
1p34.3
AA seq 919 aa AA seqDB search
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
NT seq 2760 nt NT seq  +upstreamnt  +downstreamnt
atgaccgctccctggcggcgcctccggagtctggtttgggaatactgggccgggctcctc
gtgtgcgccttctggatcccggactcgcgcgggatgccccacgtcatccggatcggagga
atcttcgagtatgcggacggccccaacgcccaggtcatgaatgccgaggagcatgccttt
cgattttctgccaacatcatcaacaggaacaggactctgctgcccaacacaaccttgacc
tatgacatacagaggattcacttccatgacagcttcgaggcgaccaaaaaggcctgtgac
cagctggcactgggcgtggtggcgatcttcggcccatcacagggctcctgcaccaatgcc
gtccagtccatctgcaatgccctggaggtgccccacatccagctgcgttggaagcaccac
ccgctggacaacaaggacaccttctacgtgaacctctaccccgactacgcctcgctcagc
catgccatcctcgacctggtccagtacctcaagtggcggtcagccaccgtggtctatgac
gacagtacagggctcatccgactgcaggagctcatcatggccccatcaagatacaacatc
cgcctgaagatccgtcagctccccatcgactctgacgactcgcgccccttgctcaaggag
atgaagcgaggccgggaattccgcattatcttcgactgcagccacactatggcggcccag
atcctcaagcaggccatggccatgggcatgatgactgagtactaccacttcatcttcacc
actctggatctctacgctttagacctggagccctaccgctactcaggcgtgaacctgaca
ggattccggattctcaatgtggacaacccacacgtctcggccattgtggagaagtggtcc
atggagcggctgcaggcagctccccggtccgagtctggcctgctggatggagtgatgatg
actgatgcagccttactgtacgacgccgtccatatcgtgtccgtgtgctaccagcgggca
ccacagatgaccgtgaactccctgcagtgccatcggcacaaggcctggcgctttggcggc
cgcttcatgaacttcatcaaggaggctcaatgggaaggattaactggacgaattgttttc
aacaaaactagtggcttgcggacggattttgatctggacatcatcagcctgaaagaggat
ggcctggagaaggttggggtgtggagtcctgccgacgggctcaacatcactgaggttgcc
aaaggccgaggccctaatgtcaccgactctctgacaaacagatcactcattgtcaccaca
gtgctggaggagcccttcgtcatgtttcggaaatcagacaggacgctatacgggaatgac
cggttcgagggctactgcatcgacctgctaaaggagctggcccacatccttggtttctcc
tatgagatccggctggtggaggacggcaagtacggggcacaggatgacaagggccagtgg
aacggcatggtcaaggagctcatcgaccacaaggcagatctggccgtggcccccctgacc
atcacccatgttcgagagaaggccatcgacttctccaagcccttcatgacacttggtgtg
agcatcctgtatcgaaagcccaatggcaccaaccccagcgtcttctccttcctcaatccc
ctgtccccagacatctggatgtatgttctcctcgcctacctgggggtcagctgtgtcctc
ttcgtcatcgccaggttcagcccttatgagtggtacgatgctcacccctgcaaccctggc
tccgaggtggtggaaaataacttcactctgcttaacagcttctggtttggaatgggatcc
ctgatgcagcaagggtctgagctgatgcccaaagccctgtccacacgcatcattggtggc
atctggtggttcttcacgctcatcatcatctcttcctacacggccaacctggctgccttt
ctgaccgtggagcgcatggaatcacccattgactctgctgatgacctggccaagcaaacc
aaaatcgagtatggggctgtcaaggatggggccaccatgaccttcttcaagaaatccaag
atctccaccttcgagaagatgtgggccttcatgagcagcaagccatcggcgctggtgaag
aacaacgaggagggcatccagagggccctgacggccgactacgcgctgctcatggagtcc
accaccatcgagtacgtcacgcagaggaactgcaacctcacccagatcgggggcctcatt
gactccaagggctacggcatcggcacgcccatgggctccccataccgggacaagatcacc
atcgccatcctgcagcttcaggaggaggacaagctgcatatcatgaaggagaagtggtgg
cggggcagcgggtgtcctgaggaggaaaacaaagaggccagtgccctggggatccagaag
atcgggggcatcttcattgtcctggccgccgggctggtcctctctgtgctggtggccgtg
ggcgagtttgtgtacaagctccgcaaaacagcagagagagagcagcgttccttctgcagc
accgtggccgatgagatccgtttctcccttacctgccagcgtcgagtcaagcacaagcct
cagcctcccatgatggtcaagactgacgccgtcatcaacatgcacacattcaatgaccgc
cggcttcccggcaaggacagcatggcctgcagcacatccttagcccctgtgttcccctag

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