KEGG   Homo sapiens (human): 29881
Entry
29881             CDS       T01001                                 

Gene name
NPC1L1, LDLCQ7, NPC11L1, SLC65A2
Definition
(RefSeq) NPC1 like intracellular cholesterol transporter 1
  KO
K14461  Niemann-Pick C1-like protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04975  Fat digestion and absorption
Drug target
Ezetimibe: D01966<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04975 Fat digestion and absorption
    29881 (NPC1L1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    29881 (NPC1L1)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC65: NPC-type cholesterol transporter
   29881 (NPC1L1)
SSDB
Motif
Pfam: Patched NPC1_N Sterol-sensing MMPL Folate_rec
Other DBs
NCBI-GeneID: 29881
NCBI-ProteinID: NP_037521
OMIM: 608010
HGNC: 7898
Ensembl: ENSG00000015520
Vega: OTTHUMG00000023691
Pharos: Q9UHC9(Tclin)
UniProt: Q9UHC9
Structure
PDB: 
3QNT

Position
7p13
AA seq 1359 aa
MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN
TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF
VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA
ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV
ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI
LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV
IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY
RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT
SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL
SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM
RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV
MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE
YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV
ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL
LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV
YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW
LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP
NIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYH
KPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGL
FMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVS
AVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQ
LIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCP
NHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF
NT seq 4080 nt   +upstreamnt  +downstreamnt
atggcggaggccggcctgaggggctggctgctgtgggccctgctcctgcgcttggcccag
agtgagccttacacaaccatccaccagcctggctactgcgccttctatgacgaatgtggg
aagaacccagagctgtctggaagcctcatgacactctccaacgtgtcctgcctgtccaac
acgccggcccgcaagatcacaggtgatcacctgatcctattacagaagatctgcccccgc
ctctacaccggccccaacacccaagcctgctgctccgccaagcagctggtatcactggaa
gcgagtctgtcgatcaccaaggccctcctcacccgctgcccagcctgctctgacaatttt
gtgaacctgcactgccacaacacgtgcagccccaatcagagcctcttcatcaatgtgacc
cgcgtggcccagctaggggctggacaactcccagctgtggtggcctatgaggccttctac
cagcatagctttgccgagcagagctatgactcctgcagccgtgtgcgcgtccctgcagct
gccacgctggctgtgggcaccatgtgtggcgtgtatggctctgccctttgcaatgcccag
cgctggctcaacttccagggagacacaggcaatggtctggccccactggacatcaccttc
cacctcttggagcctggccaggccgtggggagtgggattcagcctctgaatgagggggtt
gcacgttgcaatgagtcccaaggtgacgacgtggcgacctgctcctgccaagactgtgct
gcatcctgtcctgccatagcccgcccccaggccctcgactccaccttctacctgggccag
atgccgggcagtctggtcctcatcatcatcctctgctctgtcttcgctgtggtcaccatc
ctgcttgtgggattccgtgtggcccccgccagggacaaaagcaagatggtggaccccaag
aagggcaccagcctctctgacaagctcagcttctccacccacaccctccttggccagttc
ttccagggctggggcacgtgggtggcttcgtggcctctgaccatcttggtgctatctgtc
atcccggtggtggccttggcagcgggcctggtctttacagaactcactacggaccccgtg
gagctgtggtcggcccccaacagccaagcccggagtgagaaagctttccatgaccagcat
ttcggccccttcttccgaaccaaccaggtgatcctgacggctcctaaccggtccagctac
aggtatgactctctgctgctggggcccaagaacttcagcggaatcctggacctggacttg
ctgctggagctgctagagctgcaggagaggctgcggcacctccaggtatggtcgcccgaa
gcacagcgcaacatctccctgcaggacatctgctacgcccccctcaatccggacaatacc
agtctctacgactgctgcatcaacagcctcctgcagtatttccagaacaaccgcacgctc
ctgctgctcacagccaaccagacactgatggggcagacctcccaagtcgactggaaggac
cattttctgtactgtgccaatgccccgctcaccttcaaggatggcacagccctggccctg
agctgcatggctgactacggggcccctgtcttccccttccttgccattggggggtacaaa
ggaaaggactattctgaggcagaggccctgatcatgacgttctccctcaacaattaccct
gccggggacccccgtctggcccaggccaagctgtgggaggaggccttcttagaggaaatg
cgagccttccagcgtcggatggctggcatgttccaggtcacgttcatggctgagcgctct
ctggaagacgagatcaatcgcaccacagctgaagacctgcccatctttgccaccagctac
attgtcatattcctgtacatctctctggccctgggcagctattccagctggagccgagtg
atggtggactccaaggccacgctgggcctcggcggggtggccgtggtcctgggagcagtc
atggctgccatgggcttcttctcctacttgggtatccgctcctccctggtcatcctgcaa
gtggttcctttcctggtgctgtccgtgggggctgataacatcttcatctttgttctcgag
taccagaggctgccccggaggcctggggagccacgagaggtccacattgggcgagcccta
ggcagggtggctcccagcatgctgttgtgcagcctctctgaggccatctgcttcttccta
ggggccctgacccccatgccagctgtgcggacctttgccctgacctctggccttgcagtg
atccttgacttcctcctgcagatgtcagcctttgtggccctgctctccctggacagcaag
aggcaggaggcctcccggttggacgtctgctgctgtgtcaagccccaggagctgcccccg
cctggccagggagaggggctcctgcttggcttcttccaaaaggcttatgcccccttcctg
ctgcactggatcactcgaggtgttgtgctgctgctgtttctcgccctgttcggagtgagc
ctctactccatgtgccacatcagcgtgggactggaccaggagctggccctgcccaaggac
tcgtacctgcttgactatttcctctttctgaaccgctacttcgaggtgggggccccggtg
tactttgttaccaccttgggctacaacttctccagcgaggctgggatgaatgccatctgc
tccagtgcaggctgcaacaacttctccttcacccagaagatccagtatgccacagagttc
cctgagcagtcttacctggccatccctgcctcctcctgggtggatgacttcattgactgg
ctgaccccgtcctcctgctgccgcctttatatatctggccccaataaggacaagttctgc
ccctcgaccgtcaactctctgaactgcctaaagaactgcatgagcatcacgatgggctct
gtgaggccctcggtggagcagttccataagtatcttccctggttcctgaacgaccggccc
aacatcaaatgtcccaaaggcggcctggcagcatacagcacctctgtgaacttgacttca
gatggccaggttttagacacagttgccattctgtcacccaggctggagtacagtggcaca
atctcggctcactgcaacctctacctcctggattcaacctccaggttcatggcctatcac
aagcccctgaaaaactcacaggattacacagaagctctgcgggcagctcgagagctggca
gccaacatcactgctgacctgcggaaagtgcctggaacagacccggcttttgaggtcttc
ccctacacgatcaccaatgtgttttatgagcagtacctgaccatcctccctgaggggctc
ttcatgctcagcctctgccttgtgcccaccttcgctgtctcctgcctcctgctgggcctg
gacctgcgctccggcctcctcaacctgctctccattgtcatgatcctcgtggacactgtc
ggcttcatggccctgtggggcatcagttacaatgctgtgtccctcatcaacctggtctcg
gcggtgggcatgtctgtggagtttgtgtcccacattacccgctcctttgccatcagcacc
aagcccacctggctggagagggccaaagaggccaccatctctatgggaagtgcggtgttt
gcaggtgtggccatgaccaacctgcctggcatccttgtcctgggcctcgccaaggcccag
ctcattcagatcttcttcttccgcctcaacctcctgatcactctgctgggcctgctgcat
ggcttggtcttcctgcccgtcatcctcagctacgtggggcctgacgttaacccggctctg
gcactggagcagaagcgggctgaggaggcggtggcagcagtcatggtggcctcttgccca
aatcacccctcccgagtctccacagctgacaacatctatgtcaaccacagctttgaaggt
tctatcaaaggtgctggtgccatcagcaacttcttgcccaacaatgggcggcagttctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (24)   
   RefSeq(nuc) (6)   
   GenBank (9)   
   EMBL (9)   
Protein domain (5)   
   Pfam (5)   
All databases (72)   

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