KEGG T01001: 3356

Homo sapiens (human): 3356

Entry

3356              CDS       T01001

Symbol

HTR2A, 5-HT2A, HTR2

Name

(RefSeq) 5-hydroxytryptamine receptor 2A

K04157

5-hydroxytryptamine receptor 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04540

Gap junction

hsa04726

Serotonergic synapse

hsa04750

Inflammatory mediator regulation of TRP channels

Disease

H01450

Obsessive-compulsive disorder

H01611

Alcohol dependence

H01646

Major depressive disorder

H01649

Schizophrenia

Drug target

Adatanserin hydrochloride:

D02767

Altanserin tartrate:

D02836

Amesergide:

D02893

Aripiprazole (DG00906):

D01164<JP/US> D10355 D10364<US> D10516<JP/US>

Asenapine (DG03100):

D02995<JP/US> D11769<US>

Atiprosin maleate:

D03005

Blonanserin:

D01176<JP>

Brexpiprazole:

D10309<JP/US>

Cariprazine (DG01305):

D09876<US> D09997

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Cinitapride (DG01520):

D07700 D07701

Cisapride (DG00056):

D00274 D02092

Clozapine:

D00283<JP/US>

Cyamemazine (DG00872):

D07307 D07756

Cyproheptadine (DG01109):

D02234<JP/US> D07765

Dimetotiazine (DG00843):

D01902<JP> D07854

Eplivanserin:

D10006

Esmirtazapine maleate:

D04055

Fananserin:

D02656

Fenfluramine (DG00103):

D04148<JP/US> D07945

Flibanserin:

D02577<US>

Glemanserin:

D04320

Iloperidone:

D02666<US>

Ketanserin (DG00265):

D02363 D08099

Loxapine (DG00897):

D00794<US> D02340<US> D08148

Lubazodone hydrochloride:

D04788

Lumateperone (DG02937):

D11169 D11170<US>

Lurasidone:

D04820<JP/US>

Mesoridazine (DG00883):

D00795 D02671

Methysergide (DG00835):

D00681 D02357

Metrenperone:

D05015

Mianserin (DG00951):

D01358<JP> D08216

Mirtazapine (DG02838):

D00563<JP/US> D11056

Mosapramine (DG00905):

D01548<JP> D08235

Naftidrofuryl (DG00290):

D05107 D08244

Nefazodone (DG00953):

D00819<US> D08257

Nelotanserin:

D09645

Ocaperidone:

D02675

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Opipramol (DG00930):

D01477 D08297

Paliperidone (DG00907):

D05339<JP/US> D05340<JP/US>

Pelanserin hydrochloride:

D05395

Periciazine:

D01485<JP>

Perospirone hydrochloride hydrate:

D02372<JP>

Pimavanserin:

D08969<US>

Pipotiazine (DG00884):

D02680 D08385

Pizotifen (DG00842):

D05523 D08397

Pruvanserin (DG01278):

D06632 D06633

Quetiapine (DG00899):

D00458<JP/US> D08456

Risperidone:

D00426<JP/US>

Ritanserin:

D05738

Sarpogrelate (DG01333):

D01624<JP> D08508

Sergolexole maleate:

D05829

Sertindole:

D00561

Setoperone:

D02686

Temanogrel (DG01334):

D09976 D09977

Tiospirone hydrochloride:

D02688

Trazodone (DG00952):

D00820<JP/US> D08626

Tropanserin hydrochloride:

D06253

Xylamidine tosylate:

D06343

Zicronapine (DG01539):

D10329 D10495

Ziprasidone (DG00892):

D01939<US> D02100<US> D08687

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3356 (HTR2A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3356 (HTR2A)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    3356 (HTR2A)
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3356 (HTR2A)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3356 (HTR2A)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3356 (HTR2A)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Serotonin
    3356 (HTR2A)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P28223(Tclin)

UniProt:

P28223

Structure

Position

13:complement(46831546..46898082)

AA seq 471 aa
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV

NT seq 1416 nt +upstreamnt +downstreamnt
atggatattctttgtgaagaaaatacttctttgagctcaactacgaactccctaatgcaa
ttaaatgatgacaccaggctctacagtaatgactttaactccggagaagctaacacttct
gatgcatttaactggacagtcgactctgaaaatcgaaccaacctttcctgtgaagggtgc
ctctcaccgtcgtgtctctccttacttcatctccaggaaaaaaactggtctgctttactg
acagccgtagtgattattctaactattgctggaaacatactcgtcatcatggcagtgtcc
ctagagaaaaagctgcagaatgccaccaactatttcctgatgtcacttgccatagctgat
atgctgctgggtttccttgtcatgcccgtgtccatgttaaccatcctgtatgggtaccgg
tggcctctgccgagcaagctttgtgcagtctggatttacctggacgtgctcttctccacg
gcctccatcatgcacctctgcgccatctcgctggaccgctacgtcgccatccagaatccc
atccaccacagccgcttcaactccagaactaaggcatttctgaaaatcattgctgtttgg
accatatcagtaggtatatccatgccaataccagtctttgggctacaggacgattcgaag
gtctttaaggaggggagttgcttactcgccgatgataactttgtcctgatcggctctttt
gtgtcatttttcattcccttaaccatcatggtgatcacctactttctaactatcaagtca
ctccagaaagaagctactttgtgtgtaagtgatcttggcacacgggccaaattagcttct
ttcagcttcctccctcagagttctttgtcttcagaaaagctcttccagcggtcgatccat
agggagccagggtcctacacaggcaggaggactatgcagtccatcagcaatgagcaaaag
gcatgcaaggtgctgggcatcgtcttcttcctgtttgtggtgatgtggtgccctttcttc
atcacaaacatcatggccgtcatctgcaaagagtcctgcaatgaggatgtcattggggcc
ctgctcaatgtgtttgtttggatcggttatctctcttcagcagtcaacccactagtctac
acactgttcaacaagacctataggtcagccttttcacggtatattcagtgtcagtacaag
gaaaacaaaaaaccattgcagttaattttagtgaacacaataccggctttggcctacaag
tctagccaacttcaaatgggacaaaaaaagaattcaaagcaagatgccaagacaacagat
aatgactgctcaatggttgctctaggaaagcagcattctgaagaggcttctaaagacaat
agcgacggagtgaatgaaaaggtgagctgtgtgtga

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