KEGG   Homo sapiens (human): 3702
Entry
3702              CDS       T01001                                 
Symbol
ITK, EMT, LPFS1, LYK, PSCTK2
Name
(RefSeq) IL2 inducible T cell kinase
  KO
K07363  IL2-inducible T-cell kinase [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04670  Leukocyte transendothelial migration
Disease
H00107  Other well-defined immunodeficiency syndromes
H01970  Lymphoproliferative syndrome
Drug target
Soquelitinib: D12762
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    3702 (ITK)
   04670 Leukocyte transendothelial migration
    3702 (ITK)
   04062 Chemokine signaling pathway
    3702 (ITK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3702 (ITK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     3702 (ITK)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  TEC family
   3702 (ITK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 PH SH3_1 BTK SH3_9 SH3_10 SH3_2 PH_8 SH3_3 ABC1 SH3_4
Other DBs
NCBI-GeneID: 3702
NCBI-ProteinID: NP_005537
OMIM: 186973
HGNC: 6171
Ensembl: ENSG00000113263
Pharos: Q08881(Tclin)
UniProt: Q08881
Structure
Position
5:157180840..157255185
AA seq 620 aa
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
NT seq 1863 nt   +upstreamnt  +downstreamnt
atgaacaactttatcctcctggaagaacagctcatcaagaaatcccaacaaaagagaaga
acttctccctcgaactttaaagtccgcttctttgtgttaaccaaagccagcctggcatac
tttgaagatcgtcatgggaagaagcgcacgctgaaggggtccattgagctctcccgaatc
aaatgtgttgagattgtgaaaagtgacatcagcatcccatgccactataaatacccgttt
caggtggtgcatgacaactacctcctatatgtgtttgctccagatcgtgagagccggcag
cgctgggtgctggcccttaaagaagaaacgaggaataataacagtttggtgcctaaatat
catcctaatttctggatggatgggaagtggaggtgctgttctcagctggagaagcttgca
acaggctgtgcccaatatgatccaaccaagaatgcttcaaagaagcctcttcctcctact
cctgaagacaacaggcgaccactttgggaacctgaagaaactgtggtcattgccttatat
gactaccaaaccaatgatcctcaggaactcgcactgcggcgcaacgaagagtactgcctg
ctggacagttctgagattcactggtggagagtccaggacaggaatgggcatgaaggatat
gtaccaagcagttatctggtggaaaaatctccaaataatctggaaacctatgagtggtac
aataagagtatcagccgagacaaagctgaaaaacttcttttggacacaggcaaagaagga
gccttcatggtaagggattccaggactgcaggaacatacaccgtgtctgttttcaccaag
gctgttgtaagtgagaacaatccctgtataaagcattatcacatcaaggaaacaaatgac
aatcctaagcgatactatgtggctgaaaagtatgtgttcgattccatccctcttctcatc
aactatcaccaacataatggaggaggcctggtgactcgactccggtatccagtttgtttt
gggaggcagaaagccccagttacagcagggctgagatacgggaaatgggtgatcgacccc
tcagagctcacttttgtgcaagagattggcagtgggcaatttgggttggtgcatctgggc
tactggctcaacaaggacaaggtggctatcaaaaccattcgggaaggggctatgtcagaa
gaggacttcatagaggaggctgaagtaatgatgaaactctctcatcccaaactggtgcag
ctgtatggggtgtgcctggagcaggcccccatctgcctggtgtttgagttcatggagcac
ggctgcctgtcagattatctacgcacccagcggggactttttgctgcagagaccctgctg
ggcatgtgtctggatgtgtgtgagggcatggcctacctggaagaggcatgtgtcatccac
agagacttggctgccagaaattgtttggtgggagaaaaccaagtcatcaaggtgtctgac
tttgggatgacaaggttcgttctggatgatcagtacaccagttccacaggcaccaaattc
ccggtgaagtgggcatccccagaggttttctctttcagtcgctatagcagcaagtccgat
gtgtggtcatttggtgtgctgatgtgggaagttttcagtgaaggcaaaatcccgtatgaa
aaccgaagcaactcagaggtggtggaagacatcagtaccggatttcggttgtacaagccc
cggctggcctccacacacgtctaccagattatgaatcactgctggaaagagagaccagaa
gatcggccagccttctccagactgctgcgtcaactggctgaaattgcagaatcaggactt
tag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (36)   
   PDB (36)   
Protein domain (13)   
   Pfam (13)   
All databases (101)   

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