KEGG   Homo sapiens (human): 3702
Entry
3702              CDS       T01001                                 

Gene name
ITK, EMT, LPFS1, LYK, PSCTK2
Definition
(RefSeq) IL2 inducible T cell kinase
  KO
K07363  IL2-inducible T-cell kinase [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04670  Leukocyte transendothelial migration
Disease
H00107  Other well-defined immunodeficiency syndromes
H01970  Lymphoproliferative syndrome 1
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    3702 (ITK)
   04670 Leukocyte transendothelial migration
    3702 (ITK)
   04062 Chemokine signaling pathway
    3702 (ITK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3702 (ITK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     3702 (ITK)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  TEC family
   3702 (ITK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 PH BTK SH3_9 SH3_10 SH3_2 PH_8 SH3_3 ABC1 SH3_4 PH_3 APH
Other DBs
NCBI-GeneID: 3702
NCBI-ProteinID: NP_005537
OMIM: 186973
HGNC: 6171
Ensembl: ENSG00000113263
Vega: OTTHUMG00000130245
Pharos: Q08881(Tclin)
UniProt: Q08881
Structure
PDB: 

Position
5q33.3
AA seq 620 aa
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
NT seq 1863 nt   +upstreamnt  +downstreamnt
atgaacaactttatcctcctggaagaacagctcatcaagaaatcccaacaaaagagaaga
acttctccctcgaactttaaagtccgcttctttgtgttaaccaaagccagcctggcatac
tttgaagatcgtcatgggaagaagcgcacgctgaaggggtccattgagctctcccgaatc
aaatgtgttgagattgtgaaaagtgacatcagcatcccatgccactataaatacccgttt
caggtggtgcatgacaactacctcctatatgtgtttgctccagatcgtgagagccggcag
cgctgggtgctggcccttaaagaagaaacgaggaataataacagtttggtgcctaaatat
catcctaatttctggatggatgggaagtggaggtgctgttctcagctggagaagcttgca
acaggctgtgcccaatatgatccaaccaagaatgcttcaaagaagcctcttcctcctact
cctgaagacaacaggcgaccactttgggaacctgaagaaactgtggtcattgccttatat
gactaccaaaccaatgatcctcaggaactcgcactgcggcgcaacgaagagtactgcctg
ctggacagttctgagattcactggtggagagtccaggacaggaatgggcatgaaggatat
gtaccaagcagttatctggtggaaaaatctccaaataatctggaaacctatgagtggtac
aataagagtatcagccgagacaaagctgaaaaacttcttttggacacaggcaaagaagga
gccttcatggtaagggattccaggactgcaggaacatacaccgtgtctgttttcaccaag
gctgttgtaagtgagaacaatccctgtataaagcattatcacatcaaggaaacaaatgac
aatcctaagcgatactatgtggctgaaaagtatgtgttcgattccatccctcttctcatc
aactatcaccaacataatggaggaggcctggtgactcgactccggtatccagtttgtttt
gggaggcagaaagccccagttacagcagggctgagatacgggaaatgggtgatcgacccc
tcagagctcacttttgtgcaagagattggcagtgggcaatttgggttggtgcatctgggc
tactggctcaacaaggacaaggtggctatcaaaaccattcgggaaggggctatgtcagaa
gaggacttcatagaggaggctgaagtaatgatgaaactctctcatcccaaactggtgcag
ctgtatggggtgtgcctggagcaggcccccatctgcctggtgtttgagttcatggagcac
ggctgcctgtcagattatctacgcacccagcggggactttttgctgcagagaccctgctg
ggcatgtgtctggatgtgtgtgagggcatggcctacctggaagaggcatgtgtcatccac
agagacttggctgccagaaattgtttggtgggagaaaaccaagtcatcaaggtgtctgac
tttgggatgacaaggttcgttctggatgatcagtacaccagttccacaggcaccaaattc
ccggtgaagtgggcatccccagaggttttctctttcagtcgctatagcagcaagtccgat
gtgtggtcatttggtgtgctgatgtgggaagttttcagtgaaggcaaaatcccgtatgaa
aaccgaagcaactcagaggtggtggaagacatcagtaccggatttcggttgtacaagccc
cggctggcctccacacacgtctaccagattatgaatcactgctggaaagagagaccagaa
gatcggccagccttctccagactgctgcgtcaactggctgaaattgcagaatcaggactt
tag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
Protein domain (15)   
   Pfam (15)   
All databases (69)   

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KEGG   Homo sapiens (human): 7006
Entry
7006              CDS       T01001                                 

Gene name
TEC, PSCTK4
Definition
(RefSeq) tec protein tyrosine kinase
  KO
K07364  tyrosine-protein kinase Tec [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04380  Osteoclast differentiation
hsa04660  T cell receptor signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    7006 (TEC)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7006 (TEC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7006 (TEC)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     7006 (TEC)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  TEC family
   7006 (TEC)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 PH SH3_1 BTK SH3_9 SH3_2 SH3_10 ABC1 Kinase-like
Other DBs
NCBI-GeneID: 7006
NCBI-ProteinID: NP_003206
OMIM: 600583
HGNC: 11719
Ensembl: ENSG00000135605
Vega: OTTHUMG00000128623
Pharos: P42680(Tchem)
UniProt: P42680
Structure
PDB: 
2LUL

Position
4p12-p11
AA seq 631 aa
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
CWQEKPEGRPSFEDLLRTIDELVECEETFGR
NT seq 1896 nt   +upstreamnt  +downstreamnt
atgaattttaacactattttggaggagattcttattaaaaggtcacagcagaaaaagaag
acatcgcccttaaactacaaagagagactttttgtacttacaaagtccatgctaacctac
tatgagggtcgagcagagaagaaatacagaaaggggtttattgatgtttcaaaaatcaag
tgtgtggaaatagtgaagaatgatgatggtgtcattccctgtcaaaataagtatccattt
caggttgttcatgatgctaacacactttacatttttgcacctagtccacaaagcagggac
ctgtgggtgaagaagttaaaagaagaaataaagaacaacaataatattatgattaaatat
catcctaaattctggacagatggaagttatcagtgttgtagacaaactgaaaaattagca
cccggatgtgaaaaatacaatctttttgagagcagtataagaaaagcactacctccagca
ccagaaacaaagaagcgaaggcctcccccaccaattccactagaagaagaagataatagt
gaagaaatcgttgtagccatgtatgatttccaagcagcagaaggacatgatctcagatta
gagagaggccaagagtatctcattttagaaaagaatgatgttcattggtggagagcaaga
gataaatatgggaatgaaggatatatcccaagtaattacgtaacgggaaagaaatcaaac
aacttagatcaatatgaatggtattgcagaaatatgaatagaagcaaggcagagcaactc
ctccgcagtgaagataaagaaggtggttttatggtaagggattccagtcaaccaggcttg
tacacagtctccctttataccaagtttggaggagaaggttcatcgggttttaggcattat
catataaaggaaacaacaacatctccaaagaagtattacctagctgaaaaacatgctttt
ggctccattcctgagattattgaatatcataagcacaatgcagcaggacttgtcaccagg
cttcggtacccagttagtgtgaaagggaagaatgcacccaccactgcaggattcagctat
gagaaatgggagattaacccttcagaactgacctttatgagggaattgggaagtggactg
tttggagtggtgaggcttggcaaatggcgagcccagtacaaagtcgcaatcaaagctatt
cgggaaggtgcaatgtgcgaggaggactttatagaagaagctaaagtgatgatgaaactg
acacacccgaagttagtgcagctttatggtgtgtgcacccagcagaaaccaatatacatt
gttactgagttcatggaaaggggctgccttctgaatttcctccgacagagacaaggtcat
ttcagtagagacgtactgctgagcatgtgtcaggatgtgtgtgaagggatggagtatctg
gagagaaacagcttcatccacagagatctggctgccagaaattgtctagtaagtgaggcg
ggagttgtaaaagtatctgattttggaatggccaggtatgttctggatgatcagtacaca
agttcttctggtgctaagtttcctgtgaagtggtgtccacctgaagtgtttaattacagc
cgcttcagcagcaaatcagatgtctggtcatttggtgttttaatgtgggaagtattcacg
gaaggcagaatgccttttgaaaaatacaccaattatgaagtggtaaccatggttactcga
ggccaccgactctaccagccgaagttggcgtccaactatgtgtatgaggtgatgctgaga
tgttggcaggagaaaccagagggaaggccttctttcgaagatctgctgcgcacaatagat
gaactagttgaatgtgaagaaacttttggaagataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (16)   
   RefSeq(nuc) (8)   
   GenBank (4)   
   EMBL (4)   
Protein domain (11)   
   Pfam (11)   
All databases (53)   

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