KEGG   Homo sapiens (human): 3702
Entry
3702              CDS       T01001                                 
Symbol
ITK, EMT, LPFS1, LYK, PSCTK2
Name
(RefSeq) IL2 inducible T cell kinase
  KO
K07363  IL2-inducible T-cell kinase [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04670  Leukocyte transendothelial migration
Disease
H00107  Other well-defined immunodeficiency syndromes
H01970  Lymphoproliferative syndrome
Drug target
Soquelitinib: D12762
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    3702 (ITK)
   04670 Leukocyte transendothelial migration
    3702 (ITK)
   04062 Chemokine signaling pathway
    3702 (ITK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3702 (ITK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     3702 (ITK)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  TEC family
   3702 (ITK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 PH SH3_1 BTK SH3_9 SH3_10 SH3_2 PH_8 SH3_3 ABC1 SH3_4
Other DBs
NCBI-GeneID: 3702
NCBI-ProteinID: NP_005537
OMIM: 186973
HGNC: 6171
Ensembl: ENSG00000113263
UniProt: Q08881
Structure
Position
5:157180840..157255185
AA seq 620 aa
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
NT seq 1863 nt   +upstreamnt  +downstreamnt
atgaacaactttatcctcctggaagaacagctcatcaagaaatcccaacaaaagagaaga
acttctccctcgaactttaaagtccgcttctttgtgttaaccaaagccagcctggcatac
tttgaagatcgtcatgggaagaagcgcacgctgaaggggtccattgagctctcccgaatc
aaatgtgttgagattgtgaaaagtgacatcagcatcccatgccactataaatacccgttt
caggtggtgcatgacaactacctcctatatgtgtttgctccagatcgtgagagccggcag
cgctgggtgctggcccttaaagaagaaacgaggaataataacagtttggtgcctaaatat
catcctaatttctggatggatgggaagtggaggtgctgttctcagctggagaagcttgca
acaggctgtgcccaatatgatccaaccaagaatgcttcaaagaagcctcttcctcctact
cctgaagacaacaggcgaccactttgggaacctgaagaaactgtggtcattgccttatat
gactaccaaaccaatgatcctcaggaactcgcactgcggcgcaacgaagagtactgcctg
ctggacagttctgagattcactggtggagagtccaggacaggaatgggcatgaaggatat
gtaccaagcagttatctggtggaaaaatctccaaataatctggaaacctatgagtggtac
aataagagtatcagccgagacaaagctgaaaaacttcttttggacacaggcaaagaagga
gccttcatggtaagggattccaggactgcaggaacatacaccgtgtctgttttcaccaag
gctgttgtaagtgagaacaatccctgtataaagcattatcacatcaaggaaacaaatgac
aatcctaagcgatactatgtggctgaaaagtatgtgttcgattccatccctcttctcatc
aactatcaccaacataatggaggaggcctggtgactcgactccggtatccagtttgtttt
gggaggcagaaagccccagttacagcagggctgagatacgggaaatgggtgatcgacccc
tcagagctcacttttgtgcaagagattggcagtgggcaatttgggttggtgcatctgggc
tactggctcaacaaggacaaggtggctatcaaaaccattcgggaaggggctatgtcagaa
gaggacttcatagaggaggctgaagtaatgatgaaactctctcatcccaaactggtgcag
ctgtatggggtgtgcctggagcaggcccccatctgcctggtgtttgagttcatggagcac
ggctgcctgtcagattatctacgcacccagcggggactttttgctgcagagaccctgctg
ggcatgtgtctggatgtgtgtgagggcatggcctacctggaagaggcatgtgtcatccac
agagacttggctgccagaaattgtttggtgggagaaaaccaagtcatcaaggtgtctgac
tttgggatgacaaggttcgttctggatgatcagtacaccagttccacaggcaccaaattc
ccggtgaagtgggcatccccagaggttttctctttcagtcgctatagcagcaagtccgat
gtgtggtcatttggtgtgctgatgtgggaagttttcagtgaaggcaaaatcccgtatgaa
aaccgaagcaactcagaggtggtggaagacatcagtaccggatttcggttgtacaagccc
cggctggcctccacacacgtctaccagattatgaatcactgctggaaagagagaccagaa
gatcggccagccttctccagactgctgcgtcaactggctgaaattgcagaatcaggactt
tag

  All links  
Disease (2)   
   OMIM (2)   
Gene (13)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (36)   
   PDB (36)   
Protein domain (13)   
   Pfam (13)   
All databases (88)   

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KEGG   Homo sapiens (human): 7006
Entry
7006              CDS       T01001                                 
Symbol
TEC, PSCTK4
Name
(RefSeq) tec protein tyrosine kinase
  KO
K07364  tyrosine-protein kinase Tec [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04380  Osteoclast differentiation
hsa04660  T cell receptor signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    7006 (TEC)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7006 (TEC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7006 (TEC)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     7006 (TEC)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  TEC family
   7006 (TEC)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 PH SH3_1 BTK SH3_2 SH3_9 SH3_10 ABC1 PH_3 Kinase-like
Other DBs
NCBI-GeneID: 7006
NCBI-ProteinID: NP_003206
OMIM: 600583
HGNC: 11719
Ensembl: ENSG00000135605
UniProt: P42680
Structure
Position
4:complement(48135783..48269838)
AA seq 631 aa
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
CWQEKPEGRPSFEDLLRTIDELVECEETFGR
NT seq 1896 nt   +upstreamnt  +downstreamnt
atgaattttaacactattttggaggagattcttattaaaaggtcacagcagaaaaagaag
acatcgcccttaaactacaaagagagactttttgtacttacaaagtccatgctaacctac
tatgagggtcgagcagagaagaaatacagaaaggggtttattgatgtttcaaaaatcaag
tgtgtggaaatagtgaagaatgatgatggtgtcattccctgtcaaaataagtatccattt
caggttgttcatgatgctaacacactttacatttttgcacctagtccacaaagcagggac
ctgtgggtgaagaagttaaaagaagaaataaagaacaacaataatattatgattaaatat
catcctaaattctggacagatggaagttatcagtgttgtagacaaactgaaaaattagca
cccggatgtgaaaaatacaatctttttgagagcagtataagaaaagcactacctccagca
ccagaaacaaagaagcgaaggcctcccccaccaattccactagaagaagaagataatagt
gaagaaatcgttgtagccatgtatgatttccaagcagcagaaggacatgatctcagatta
gagagaggccaagagtatctcattttagaaaagaatgatgttcattggtggagagcaaga
gataaatatgggaatgaaggatatatcccaagtaattacgtaacgggaaagaaatcaaac
aacttagatcaatatgaatggtattgcagaaatatgaatagaagcaaggcagagcaactc
ctccgcagtgaagataaagaaggtggttttatggtaagggattccagtcaaccaggcttg
tacacagtctccctttataccaagtttggaggagaaggttcatcgggttttaggcattat
catataaaggaaacaacaacatctccaaagaagtattacctagctgaaaaacatgctttt
ggctccattcctgagattattgaatatcataagcacaatgcagcaggacttgtcaccagg
cttcggtacccagttagtgtgaaagggaagaatgcacccaccactgcaggattcagctat
gagaaatgggagattaacccttcagaactgacctttatgagggaattgggaagtggactg
tttggagtggtgaggcttggcaaatggcgagcccagtacaaagtcgcaatcaaagctatt
cgggaaggtgcaatgtgcgaggaggactttatagaagaagctaaagtgatgatgaaactg
acacacccgaagttagtgcagctttatggtgtgtgcacccagcagaaaccaatatacatt
gttactgagttcatggaaaggggctgccttctgaatttcctccgacagagacaaggtcat
ttcagtagagacgtactgctgagcatgtgtcaggatgtgtgtgaagggatggagtatctg
gagagaaacagcttcatccacagagatctggctgccagaaattgtctagtaagtgaggcg
ggagttgtaaaagtatctgattttggaatggccaggtatgttctggatgatcagtacaca
agttcttctggtgctaagtttcctgtgaagtggtgtccacctgaagtgtttaattacagc
cgcttcagcagcaaatcagatgtctggtcatttggtgttttaatgtgggaagtattcacg
gaaggcagaatgccttttgaaaaatacaccaattatgaagtggtaaccatggttactcga
ggccaccgactctaccagccgaagttggcgtccaactatgtgtatgaggtgatgctgaga
tgttggcaggagaaaccagagggaaggccttctttcgaagatctgctgcgcacaatagat
gaactagttgaatgtgaagaaacttttggaagataa

  All links  
Disease (1)   
   OMIM (1)   
Gene (8)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (19)   
   RefSeq(nuc) (11)   
   GenBank (4)   
   EMBL (4)   
3D Structure (1)   
   PDB (1)   
Protein domain (12)   
   Pfam (12)   
All databases (54)   

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