KEGG   Homo sapiens (human): 3702
Entry
3702              CDS       T01001                                 

Symbol
ITK, EMT, LPFS1, LYK, PSCTK2
Name
(RefSeq) IL2 inducible T cell kinase
  KO
K07363  IL2-inducible T-cell kinase [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04670  Leukocyte transendothelial migration
Disease
H00107  Other well-defined immunodeficiency syndromes
H01970  Lymphoproliferative syndrome 1
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    3702 (ITK)
   04670 Leukocyte transendothelial migration
    3702 (ITK)
   04062 Chemokine signaling pathway
    3702 (ITK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3702 (ITK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     3702 (ITK)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  TEC family
   3702 (ITK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 PH BTK SH3_9 SH3_10 SH3_2 PH_8 SH3_3 SH3_4 PH_3 APH
Other DBs
NCBI-GeneID: 3702
NCBI-ProteinID: NP_005537
OMIM: 186973
HGNC: 6171
Ensembl: ENSG00000113263
Vega: OTTHUMG00000130245
Pharos: Q08881(Tclin)
UniProt: Q08881
Structure
PDB: 

Position
5q33.3
AA seq 620 aa
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
NT seq 1863 nt   +upstreamnt  +downstreamnt
atgaacaactttatcctcctggaagaacagctcatcaagaaatcccaacaaaagagaaga
acttctccctcgaactttaaagtccgcttctttgtgttaaccaaagccagcctggcatac
tttgaagatcgtcatgggaagaagcgcacgctgaaggggtccattgagctctcccgaatc
aaatgtgttgagattgtgaaaagtgacatcagcatcccatgccactataaatacccgttt
caggtggtgcatgacaactacctcctatatgtgtttgctccagatcgtgagagccggcag
cgctgggtgctggcccttaaagaagaaacgaggaataataacagtttggtgcctaaatat
catcctaatttctggatggatgggaagtggaggtgctgttctcagctggagaagcttgca
acaggctgtgcccaatatgatccaaccaagaatgcttcaaagaagcctcttcctcctact
cctgaagacaacaggcgaccactttgggaacctgaagaaactgtggtcattgccttatat
gactaccaaaccaatgatcctcaggaactcgcactgcggcgcaacgaagagtactgcctg
ctggacagttctgagattcactggtggagagtccaggacaggaatgggcatgaaggatat
gtaccaagcagttatctggtggaaaaatctccaaataatctggaaacctatgagtggtac
aataagagtatcagccgagacaaagctgaaaaacttcttttggacacaggcaaagaagga
gccttcatggtaagggattccaggactgcaggaacatacaccgtgtctgttttcaccaag
gctgttgtaagtgagaacaatccctgtataaagcattatcacatcaaggaaacaaatgac
aatcctaagcgatactatgtggctgaaaagtatgtgttcgattccatccctcttctcatc
aactatcaccaacataatggaggaggcctggtgactcgactccggtatccagtttgtttt
gggaggcagaaagccccagttacagcagggctgagatacgggaaatgggtgatcgacccc
tcagagctcacttttgtgcaagagattggcagtgggcaatttgggttggtgcatctgggc
tactggctcaacaaggacaaggtggctatcaaaaccattcgggaaggggctatgtcagaa
gaggacttcatagaggaggctgaagtaatgatgaaactctctcatcccaaactggtgcag
ctgtatggggtgtgcctggagcaggcccccatctgcctggtgtttgagttcatggagcac
ggctgcctgtcagattatctacgcacccagcggggactttttgctgcagagaccctgctg
ggcatgtgtctggatgtgtgtgagggcatggcctacctggaagaggcatgtgtcatccac
agagacttggctgccagaaattgtttggtgggagaaaaccaagtcatcaaggtgtctgac
tttgggatgacaaggttcgttctggatgatcagtacaccagttccacaggcaccaaattc
ccggtgaagtgggcatccccagaggttttctctttcagtcgctatagcagcaagtccgat
gtgtggtcatttggtgtgctgatgtgggaagttttcagtgaaggcaaaatcccgtatgaa
aaccgaagcaactcagaggtggtggaagacatcagtaccggatttcggttgtacaagccc
cggctggcctccacacacgtctaccagattatgaatcactgctggaaagagagaccagaa
gatcggccagccttctccagactgctgcgtcaactggctgaaattgcagaatcaggactt
tag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
Protein domain (14)   
   Pfam (14)   
All databases (68)   

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KEGG   Homo sapiens (human): 7294
Entry
7294              CDS       T01001                                 

Symbol
TXK, BTKL, PSCTK5, PTK4, RLK, TKL
Name
(RefSeq) TXK tyrosine kinase
  KO
K08016  tyrosine-protein kinase TXK [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04670  Leukocyte transendothelial migration
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    7294 (TXK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7294 (TXK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     7294 (TXK)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  TEC family
   7294 (TXK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_9 SH3_2 SH3_10
Other DBs
NCBI-GeneID: 7294
NCBI-ProteinID: NP_003319
OMIM: 600058
HGNC: 12434
Ensembl: ENSG00000074966
Vega: OTTHUMG00000102065
Pharos: P42681(Tchem)
UniProt: P42681
Structure
PDB: 
2DM0

Position
4p12
AA seq 527 aa
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
NT seq 1584 nt   +upstreamnt  +downstreamnt
atgatcctttcctcctataacaccatccagtcggttttctgttgctgctgttgctgttca
gtgcagaagcgacaaatgagaacacagataagcctgagcacagatgaagagcttccagaa
aaatacacccagcgtcgcaggccgtggctcagccaattgtcaaataagaagcaatccaac
acgggccgtgtgcagccgtcaaaacgaaagccactgcctcccctcccaccctctgaggtt
gctgaagagaagatccaagtcaaggcactttatgattttctgcccagagaaccctgtaat
ttagccttaaggagagcagaagaatacctgatactggagaaatacaatcctcactggtgg
aaggcaagagaccgtttggggaatgaaggcttaatcccaagcaactatgtgactgaaaac
aaaataactaatttagaaatatatgagtggtaccatagaaacattaccagaaatcaggca
gaacatctattgagacaagagtctaaagaaggtgcatttattgtcagagattcaagacat
ttaggatcctacacaatttccgtatttatgggagctagaagaagtacggaggctgccata
aaacattatcagataaaaaagaatgactcaggacagtggtatgtggctgaaagacacgcc
tttcaatcaatccctgagttaatctggtatcaccagcacaatgcagccggtctcatgact
cgtctccgatatccagttgggctgatgggcagttgtttaccagccacagctgggtttagc
tacgaaaagtgggagatagatccatctgagttggcttttataaaggagattggaagcggt
cagtttggagtggtccatttaggtgaatggcggtcacatatccaggtagctatcaaggcc
atcaatgaaggctccatgtctgaagaggatttcattgaagaggccaaagtgatgatgaaa
ttatctcattcaaagctagtgcaactttatggagtctgtatacagcggaagcccctttac
attgtgacagagttcatggaaaatggctgcctgcttaactatctcagggagaataaagga
aagcttaggaaggaaatgctactgagtgtatgccaggatatatgtgaaggaatggaatat
ctggagaggaatggctatattcatagggatttggcggcaaggaattgtttggtcagttca
acatgcatagtaaaaatttcagactttggaatgacaaggtacgttttggatgatgagtat
gtcagttcttttggagccaagttcccaatcaagtggtcccctcctgaagtttttcttttc
aataagtacagcagtaaatctgatgtctggtcatttggagttttaatgtgggaagttttt
acagaaggaaaaatgccttttgaaaataagtcaaatttgcaagtcgtggaagctatttct
gaaggcttcaggctatatcgccctcacctggcaccaatgtccatatatgaagtcatgtac
agctgctggcatgagaaacctgaaggccgccctacatttgccgagctgctgcgggctgtc
acagagattgcggaaacctggtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (17)   
   RefSeq(nuc) (7)   
   GenBank (5)   
   EMBL (5)   
Protein domain (7)   
   Pfam (7)   
All databases (64)   

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