Entry |
|
Symbol |
JAK3, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
|
Name |
|
KO |
|
Organism |
|
Pathway |
hsa04550 | Signaling pathways regulating pluripotency of stem cells |
hsa04658 | Th1 and Th2 cell differentiation |
hsa05166 | Human T-cell leukemia virus 1 infection |
|
Network |
nt06150 Cytokine-cytokine receptor interaction (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06162 Hepatitis B virus (HBV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06219 JAK-STAT signaling nt06263 Hepatocellular carcinoma nt06266 Non-small cell lung cancer nt06276 Chronic myeloid leukemia nt06518 JAK-STAT signaling |
Element |
N00053 | Cytokine-Jak-STAT signaling pathway |
N00105 | EML4-ALK fusion kinase to Jak-STAT signaling pathway |
N00486 | EBV LMP1 to Jak-STAT signaling pathway |
N00491 | HTLV-1 p12 to Jak-STAT signaling pathway |
N01554 | IL2 family to Jak-STAT signaling pathway |
|
Disease |
H00091 | T-B+Severe combined immunodeficiency |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3718 (JAK3)
04151 PI3K-Akt signaling pathway
3718 (JAK3)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
3718 (JAK3)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
3718 (JAK3)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
3718 (JAK3)
04659 Th17 cell differentiation
3718 (JAK3)
04062 Chemokine signaling pathway
3718 (JAK3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3718 (JAK3)
05203 Viral carcinogenesis
3718 (JAK3)
09162 Cancer: specific types
05223 Non-small cell lung cancer
3718 (JAK3)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3718 (JAK3)
05161 Hepatitis B
3718 (JAK3)
05162 Measles
3718 (JAK3)
05169 Epstein-Barr virus infection
3718 (JAK3)
09163 Immune disease
05340 Primary immunodeficiency
3718 (JAK3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
3718 (JAK3)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
3718 (JAK3)
Protein kinases [BR:hsa01001]
Non-receptor tyrosine kinases
JAK family [OT]
3718 (JAK3)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
19:complement(17824782..17847982)
|
AA seq |
1124 aa
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKA
SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL
RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQR
PGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM
DLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP
LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK
EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR
HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ
EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS
GVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS |
NT seq |
3375 nt +upstreamnt +downstreamnt
atggcacctccaagtgaagagacgcccctgatccctcagcgttcatgcagcctcttgtcc
acggaggctggtgccctgcatgtgctgctgcccgctcggggccccgggcccccccagcgc
ctatctttctcctttggggaccacttggctgaggacctgtgcgtgcaggctgccaaggcc
agcggcatcctgcctgtgtaccactccctctttgctctggccacggaggacctgtcctgc
tggttccccccgagccacatcttctccgtggaggatgccagcacccaagtcctgctgtac
aggattcgcttttacttccccaattggtttgggctggagaagtgccaccgcttcgggcta
cgcaaggatttggccagtgctatccttgacctgccagtcctggagcacctctttgcccag
caccgcagtgacctggtgagtgggcgcctccccgtgggcctcagtctcaaggagcagggt
gagtgtctcagcctggccgtgttggacctggcccggatggcgcgagagcaggcccagcgg
ccgggagagctgctgaagactgtcagctacaaggcctgcctacccccaagcctgcgcgac
ctgatccagggcctgagcttcgtgacgcggaggcgtattcggaggacggtgcgcagagcc
ctgcgccgcgtggccgcctgccaggcagaccggcactcgctcatggccaagtacatcatg
gacctggagcggctggatccagccggggccgccgagaccttccacgtgggcctccctggg
gcccttggtggccacgacgggctggggctgctccgcgtggctggtgacggcggcatcgcc
tggacccagggagaacaggaggtcctccagcccttctgcgactttccagaaatcgtagac
attagcatcaagcaggccccgcgcgttggcccggccggagagcaccgcctggtcactgtt
accaggacagacaaccagattttagaggccgagttcccagggctgcccgaggctctgtcg
ttcgtggcgctcgtggacggctacttccggctgaccacggactcccagcacttcttctgc
aaggaggtggcaccgccgaggctgctggaggaagtggccgagcagtgccacggccccatc
actctggactttgccatcaacaagctcaagactgggggctcacgtcctggctcctatgtt
ctccgccgcagcccccaggactttgacagcttcctcctcactgtctgtgtccagaacccc
cttggtcctgattataagggctgcctcatccggcgcagccccacaggaaccttccttctg
gttggcctcagccgaccccacagcagtcttcgagagctcctggcaacctgctgggatggg
gggctgcacgtagatggggtggcagtgaccctcacttcctgctgtatccccagacccaaa
gaaaagtccaacctgatcgtggtccagagaggtcacagcccacccacatcatccttggtt
cagccccaatcccaataccagctgagtcagatgacatttcacaagatccctgctgacagc
ctggagtggcatgagaacctgggccatgggtccttcaccaagatttaccggggctgtcgc
catgaggtggtggatggggaggcccgaaagacagaggtgctgctgaaggtcatggatgcc
aagcacaagaactgcatggagtcattcctggaagcagcgagcttgatgagccaagtgtcg
taccggcatctcgtgctgctccacggcgtgtgcatggctggagacagcaccatggtgcag
gaatttgtacacctgggggccatagacatgtatctgcgaaaacgtggccacctggtgcca
gccagctggaagctgcaggtggtcaaacagctggcctacgccctcaactatctggaggac
aaaggcctgccccatggcaatgtctctgcccggaaggtgctcctggctcgggagggggct
gatgggagcccgcccttcatcaagctgagtgaccctggggtcagccccgctgtgttaagc
ctggagatgctcaccgacaggatcccctgggtggcccccgagtgtctccgggaggcgcag
acacttagcttggaagctgacaagtggggcttcggcgccacggtctgggaagtgtttagt
ggcgtcaccatgcccatcagtgccctggatcctgctaagaaactccaattttatgaggac
cggcagcagctgccggcccccaagtggacagagctggccctgctgattcaacagtgcatg
gcctatgagccggtccagaggccctccttccgagccgtcattcgtgacctcaatagcctc
atctcttcagactatgagctcctctcagaccccacacctggtgccctggcacctcgtgat
gggctgtggaatggtgcccagctctatgcctgccaagaccccacgatcttcgaggagaga
cacctcaagtacatctcacagctgggcaagggcaactttggcagcgtggagctgtgccgc
tatgacccgctaggcgacaatacaggtgccctggtggccgtgaaacagctgcagcacagc
gggccagaccagcagagggactttcagcgggagattcagatcctcaaagcactgcacagt
gatttcattgtcaagtatcgtggtgtcagctatggcccgggccgccagagcctgcggctg
gtcatggagtacctgcccagcggctgcttgcgcgacttcctgcagcggcaccgcgcgcgc
ctcgatgccagccgcctccttctctattcctcgcagatctgcaagggcatggagtacctg
ggctcccgccgctgcgtgcaccgcgacctggccgcccgaaacatcctcgtggagagcgag
gcacacgtcaagatcgctgacttcggcctagctaagctgctgccgcttgacaaagactac
tacgtggtccgcgagccaggccagagccccattttctggtatgcccccgaatccctctcg
gacaacatcttctctcgccagtcagacgtctggagcttcggggtcgtcctgtacgagctc
ttcacctactgcgacaaaagctgcagcccctcggccgagttcctgcggatgatgggatgt
gagcgggatgtccccgccctctgccgcctcttggaactgctggaggagggccagaggctg
ccggcgcctcctgcctgccctgctgaggttcacgagctcatgaagctgtgctgggcccct
agcccacaggaccggccatcattcagcgccctgggcccccagctggacatgctgtggagc
ggaagccgggggtgtgagactcatgccttcactgctcacccagagggcaaacaccactcc
ctgtccttttcatag |