Entry |
|
Symbol |
LCK, IMD22, LSK, YT16, p56lck, pp58lck
|
Name |
(RefSeq) LCK proto-oncogene, Src family tyrosine kinase
|
KO |
|
Organism |
|
Pathway |
hsa04650 | Natural killer cell mediated cytotoxicity |
hsa04658 | Th1 and Th2 cell differentiation |
hsa04660 | T cell receptor signaling pathway |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Network |
nt06120 Calcium signaling (viruses and bacteria) nt06140 Transcription (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) |
Element |
N00511 | HTLV-1 Tax to E47-mediated transcription |
N01106 | TCR-NFAT signaling pathway |
N01107 | Yersinia YopH to TCR-NFAT signaling pathway |
|
Disease |
H00093 | Combined immunodeficiency |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
3932 (LCK)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
3932 (LCK)
04660 T cell receptor signaling pathway
3932 (LCK)
04658 Th1 and Th2 cell differentiation
3932 (LCK)
04659 Th17 cell differentiation
3932 (LCK)
09158 Development and regeneration
04380 Osteoclast differentiation
3932 (LCK)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
3932 (LCK)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3932 (LCK)
09171 Infectious disease: bacterial
05135 Yersinia infection
3932 (LCK)
09163 Immune disease
05340 Primary immunodeficiency
3932 (LCK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
3932 (LCK)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
3932 (LCK)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
3932 (LCK)
Protein kinases [BR:hsa01001]
Non-receptor tyrosine kinases
SRC family
3932 (LCK)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centrosome formation proteins
Kinases and associated factors
3932 (LCK)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
1:32251265..32286165
|
AA seq |
509 aa
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP |
NT seq |
1530 nt +upstreamnt +downstreamnt
atgggctgtggctgcagctcacacccggaagatgactggatggaaaacatcgatgtgtgt
gagaactgccattatcccatagtcccactggatggcaagggcacgctgctcatccgaaat
ggctctgaggtgcgggacccactggttacctacgaaggctccaatccgccggcttcccca
ctgcaagacaacctggttatcgctctgcacagctatgagccctctcacgacggagatctg
ggctttgagaagggggaacagctccgcatcctggagcagagcggcgagtggtggaaggcg
cagtccctgaccacgggccaggaaggcttcatccccttcaattttgtggccaaagcgaac
agcctggagcccgaaccctggttcttcaagaacctgagccgcaaggacgcggagcggcag
ctcctggcgcccgggaacactcacggctccttcctcatccgggagagcgagagcaccgcg
ggatcgttttcactgtcggtccgggacttcgaccagaaccagggagaggtggtgaaacat
tacaagatccgtaatctggacaacggtggcttctacatctcccctcgaatcacttttccc
ggcctgcatgaactggtccgccattacaccaatgcttcagatgggctgtgcacacggttg
agccgcccctgccagacccagaagccccagaagccgtggtgggaggacgagtgggaggtt
cccagggagacgctgaagctggtggagcggctgggggctggacagttcggggaggtgtgg
atggggtactacaacgggcacacgaaggtggcggtgaagagcctgaagcagggcagcatg
tccccggacgccttcctggccgaggccaacctcatgaagcagctgcaacaccagcggctg
gttcggctctacgctgtggtcacccaggagcccatctacatcatcactgaatacatggag
aatgggagtctagtggattttctcaagaccccttcaggcatcaagttgaccatcaacaaa
ctcctggacatggcagcccaaattgcagaaggcatggcattcattgaagagcggaattat
attcatcgtgaccttcgggctgccaacattctggtgtctgacaccctgagctgcaagatt
gcagactttggcctagcacgcctcattgaggacaacgagtacacagccagggagggggcc
aagtttcccattaagtggacagcgccagaagccattaactacgggacattcaccatcaag
tcagatgtgtggtcttttgggatcctgctgacggaaattgtcacccacggccgcatccct
tacccagggatgaccaacccggaggtgattcagaacctggagcgaggctaccgcatggtg
cgccctgacaactgtccagaggagctgtaccaactcatgaggctgtgctggaaggagcgc
ccagaggaccggcccacctttgactacctgcgcagtgtgctggaggacttcttcacggcc
acagagggccagtaccagcctcagccttga |