KEGG   Homo sapiens (human): 3990
Entry
3990              CDS       T01001                                 
Symbol
LIPC, HDLCQ12, HL, HTGL, LIPH
Name
(RefSeq) lipase C, hepatic type
  KO
K22283  hepatic triacylglycerol lipase [EC:3.1.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00561  Glycerolipid metabolism
hsa01100  Metabolic pathways
hsa04979  Cholesterol metabolism
Module
hsa_M00098  Acylglycerol degradation
Disease
H02329  Hepatic lipase deficiency
Drug target
Dextran (DG00180): D02047 D03343
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    3990 (LIPC)
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    3990 (LIPC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.3  triacylglycerol lipase
     3990 (LIPC)
SSDB
Motif
Pfam: Lipase PLAT DUF7013 Abhydrolase_6
Other DBs
NCBI-GeneID: 3990
NCBI-ProteinID: NP_000227
OMIM: 151670
HGNC: 6619
Ensembl: ENSG00000166035
UniProt: P11150 A6H8L5
Position
15:58431991..58569844
AA seq 499 aa
MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQ
GCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLV
DWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSS
IGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGH
YDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAY
PCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQF
INQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKW
ENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQ
EKIFVKCEIKSKTSKRKIR
NT seq 1500 nt   +upstreamnt  +downstreamnt
atggacacaagtcccctgtgtttctccattctgttggttttatgcatctttatccaatca
agtgcccttggacaaagcctgaaaccagagccatttggaagaagagctcaagctgttgaa
acaaacaaaacgctgcatgagatgaagaccagattcctgctctttggagaaaccaatcag
ggctgtcagattcgaatcaatcatccggacacgttacaggagtgcggcttcaactcctcc
ctgcctctggtgatgataatccacgggtggtcggtggacggcgtgctagaaaactggatc
tggcagatggtggccgcgctgaagtctcagccggcccagccagtgaacgtggggctggtg
gactggatcaccctggcccacgaccactacaccatcgccgtccgcaacacccgccttgtg
ggcaaggaggtcgcggctcttctccggtggctggaggaatctgtgcaactctctcgaagc
catgttcacctaattgggtacagcctgggtgcacacgtgtcaggatttgccggcagttcc
atcggtggaacgcacaagattgggagaatcacagggctggatgccgcgggacctttgttt
gagggaagtgcccccagcaatcgtctttctccagatgatgccaattttgtggatgccatt
catacctttacccgggagcacatgggcctgagcgtgggcatcaaacagcccataggacac
tatgacttctatcccaacgggggctccttccagcctggctgccacttcctagagctctac
agacatattgcccagcacggcttcaatgccatcacccagaccataaaatgctcccacgag
cgatcggtgcaccttttcatcgactccttgctgcacgccggcacgcagagcatggcctac
ccgtgtggtgacatgaacagcttcagccagggcctgtgcctgagctgcaagaagggccgc
tgcaacacgctgggctaccacgtccgccaggagccgcggagcaagagcaagaggctcttc
ctcgtaacgcgagcccagtcccccttcaaagtttatcattaccagttcaagatccagttc
atcaaccaaactgagacaccaatacaaacaacttttaccatgtcactactcggaacaaaa
gagaaaatgcagaaaattcccatcactctgggcaaaggaattgctagtaataaaacgtat
tcctttcttatcacgctggatgtggatatcggcgagctgatcatgatcaagttcaagtgg
gaaaacagtgcagtgtgggccaatgtctgggacacggtccagaccatcatcccatggagc
acagggccgcgccactcaggcctcgttctgaagacgatcagagtcaaagcaggagaaacc
cagcaaagaatgacattttgttcagaaaacacagatgacctactacttcgcccaacccag
gaaaaaatcttcgtgaaatgtgaaataaagtctaaaacatcaaagcgaaagatcagatga

  All links  
Disease (4)   
   OMIM (4)   
Gene (11)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (29)   
   RefSeq(nuc) (1)   
   GenBank (14)   
   EMBL (14)   
Protein domain (4)   
   Pfam (4)   
All databases (52)   

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