KEGG   Homo sapiens (human): 4296
Entry
4296              CDS       T01001                                 

Gene name
MAP3K11, MEKK11, MLK-3, MLK3, PTK1, SPRK
Definition
(RefSeq) mitogen-activated protein kinase kinase kinase 11
  KO
K04419  mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4296 (MAP3K11)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    4296 (MAP3K11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4296 (MAP3K11)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     4296 (MAP3K11)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   4296 (MAP3K11)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH3_9 SH3_1 SH3_2 Pkinase_fungal Abi_alpha
Other DBs
NCBI-GeneID: 4296
NCBI-ProteinID: NP_002410
OMIM: 600050
HGNC: 6850
Ensembl: ENSG00000173327
Vega: OTTHUMG00000166529
Pharos: Q16584(Tchem)
UniProt: Q16584 A0A024R5E6
Structure
PDB: 
5K26 6AQB 5K28 6CQ7

Position
11q13.1
AA seq 847 aa
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL
ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE
EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK
AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR
DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS
KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA
QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR
EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR
SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP
GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL
GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD
LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV
GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS
FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP
WVPEAGP
NT seq 2544 nt   +upstreamnt  +downstreamnt
atggagcccttgaagagcctcttcctcaagagccctctagggtcatggaatggcagtggc
agcgggggtggtgggggcggtggaggaggccggcctgaggggtctccaaaggcagcgggt
tatgccaacccggtgtggacagccctgttcgactacgagcccagtgggcaggatgagctg
gccctgaggaagggtgaccgtgtggaggtgctgtcccgggacgcagccatctcaggagac
gagggctggtgggcgggccaggtgggtggccaggtgggcatcttcccgtccaactatgtg
tctcggggtggcggcccgcccccctgcgaggtggccagcttccaggagctgcggctggag
gaggtgatcggcattggaggctttggcaaggtgtacaggggcagctggcgaggtgagctg
gtggctgtgaaggcagctcgccaggaccccgatgaggacatcagtgtgacagccgagagc
gttcgccaggaggcccggctcttcgccatgctggcacaccccaacatcattgccctcaag
gctgtgtgcctggaggagcccaacctgtgcctggtgatggagtatgcagccggtgggccc
ctcagccgagctctggccgggcggcgcgtgcctccccatgtgctggtcaactgggctgtg
cagattgcccgtgggatgcactacctgcactgcgaggccctggtgcccgtcatccaccgt
gatctcaagtccaacaacattttgctgctgcagcccattgagagtgacgacatggagcac
aagaccctgaagatcaccgactttggcctggcccgagagtggcacaaaaccacacaaatg
agtgccgcgggcacctacgcctggatggctcctgaggttatcaaggcctccaccttctct
aagggcagtgacgtctggagttttggggtgctgctgtgggaactgctgaccggggaggtg
ccataccgtggcattgactgccttgctgtggcctatggcgtagctgttaacaagctcaca
ctgcccatcccatccacctgccccgagcccttcgcacagcttatggccgactgctgggcg
caggacccccaccgcaggcccgacttcgcctccatcctgcagcagttggaggcgctggag
gcacaggtcctacgggaaatgccgcgggactccttccattccatgcaggaaggctggaag
cgcgagatccagggtctcttcgacgagctgcgagccaaggaaaaggaactactgagccgc
gaggaggagctgacgcgagcggcgcgcgagcagcggtcacaggcggagcagctgcggcgg
cgcgagcacctgctggcccagtgggagctagaggtgttcgagcgcgagctgacgctgctg
ctgcagcaggtggaccgcgagcgaccgcacgtgcgccgccgccgcgggacattcaagcgc
agcaagctccgggcgcgcgacggcggcgagcgtatcagcatgccactcgacttcaagcac
cgcatcaccgtgcaggcctcacccggccttgaccggaggagaaacgtcttcgaggtcggg
cctggggattcgcccacctttccccggttccgagccatccagttggagcctgcagagcca
ggccaggcatggggccgccagtccccccgacgtctggaggactcaagcaatggagagcgg
cgagcatgctgggcttggggtcccagttcccccaagcctggggaagcccagaatgggagg
agaaggtcccgcatggacgaagccacatggtacctggattcagatgactcatccccctta
ggatctccttccacacccccagcactcaatggtaaccccccgcggcctagcctggagccc
gaggagcccaagaggcctgtccccgcagagcgcggtagcagctctgggacgcccaagctg
atccagcgggcgctgctgcgcggcaccgccctgctcgcctcgctgggccttggccgcgac
ctgcagccgccgggaggcccaggacgcgagcgcggggagtccccgacaacaccccccacg
ccaacgcccgcgccctgcccgaccgagccgcccccttccccgctcatctgcttctcgctc
aagacgcccgactccccgcccactcctgcacccctgttgctggacctgggtatccctgtg
ggccagcggtcagccaagagcccccgacgtgaggaggagccccgcggaggcactgtctca
cccccaccggggacatcacgctctgctcctggcaccccaggcaccccacgttcaccaccc
ctgggcctcatcagccgacctcggccctcgccccttcgcagccgcattgatccctggagc
tttgtgtcagctgggccacggccttctcccctgccatcaccacagcctgcaccccgccga
gcaccctggaccttgttcccggactcagaccccttctgggactccccacctgccaacccc
ttccaggggggcccccaggactgcagggcacagaccaaagacatgggtgcccaggccccg
tgggtgccggaagcggggccttga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (48)   
   KEGG ORTHOLOGY (1)   
   RefGene (36)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (28)   
   RefSeq(nuc) (2)   
   GenBank (13)   
   EMBL (13)   
Protein domain (7)   
   Pfam (7)   
All databases (95)   

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