KEGG   Homo sapiens (human): 477Help
Entry
477               CDS       T01001                                 

Gene name
ATP1A2, FHM2, MHP2
Definition
(RefSeq) ATPase Na+/K+ transporting subunit alpha 2
  KO
K01539  sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04911  Insulin secretion
hsa04918  Thyroid hormone synthesis
hsa04919  Thyroid hormone signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa04964  Proximal tubule bicarbonate reclamation
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04973  Carbohydrate digestion and absorption
hsa04974  Protein digestion and absorption
hsa04976  Bile secretion
hsa04978  Mineral absorption
Disease
H00775  Familial or sporadic hemiplegic migraine
H00998  Alternating hemiplegia of childhood
Drug target
Acetyldigitoxin: D06881
Acetyldigoxin: D07555
Bepridil (DG00333): D00631 D07520
Bretylium tosilate: D00645
Deslanoside: D01240
Digitoxin: D00297
Digoxin: D00298
G-strophanthin: D00112
Gitoformate: D07147
Lanatoside C: D01972
Metildigoxin (DG00191): D02587 D09847
Proscillaridin: D01379
beta-Acetyldigoxin: D07556
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    477 (ATP1A2)
   04022 cGMP - PKG signaling pathway
    477 (ATP1A2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    477 (ATP1A2)
   04918 Thyroid hormone synthesis
    477 (ATP1A2)
   04919 Thyroid hormone signaling pathway
    477 (ATP1A2)
   04925 Aldosterone synthesis and secretion
    477 (ATP1A2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    477 (ATP1A2)
   04261 Adrenergic signaling in cardiomyocytes
    477 (ATP1A2)
  09154 Digestive system
   04970 Salivary secretion
    477 (ATP1A2)
   04971 Gastric acid secretion
    477 (ATP1A2)
   04972 Pancreatic secretion
    477 (ATP1A2)
   04976 Bile secretion
    477 (ATP1A2)
   04973 Carbohydrate digestion and absorption
    477 (ATP1A2)
   04974 Protein digestion and absorption
    477 (ATP1A2)
   04978 Mineral absorption
    477 (ATP1A2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    477 (ATP1A2)
   04961 Endocrine and other factor-regulated calcium reabsorption
    477 (ATP1A2)
   04964 Proximal tubule bicarbonate reclamation
    477 (ATP1A2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    477 (ATP1A2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.9  Na+/K+-exchanging ATPase
     477 (ATP1A2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   477 (ATP1A2)
  Exosomal proteins of other body fluids (saliva and urine)
   477 (ATP1A2)
  Exosomal proteins of colorectal cancer cells
   477 (ATP1A2)
  Exosomal proteins of bladder cancer cells
   477 (ATP1A2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: E1-E2_ATPase Cation_ATPase_C Cation_ATPase Hydrolase Cation_ATPase_N Hydrolase_3 Sigma70_r4
Motif
Other DBs
NCBI-GeneID: 477
NCBI-ProteinID: NP_000693
OMIM: 182340
HGNC: 800
Ensembl: ENSG00000018625
Vega: OTTHUMG00000024080
Pharos: P50993(Tclin)
UniProt: P50993 A0A0S2Z3W6
Position
1q23.2
AA seq 1020 aa AA seqDB search
MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKG
LTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAME
DEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINA
EEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNI
CFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFL
GVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS
RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPF
NSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYM
ELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAV
GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKAC
VVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSP
ALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN
IPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK
LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYG
QEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETA
LAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY
NT seq 3063 nt NT seq  +upstreamnt  +downstreamnt
atgggccgtggggctggccgtgagtactcacctgccgccaccacggcagagaatgggggc
ggcaagaagaaacagaaggagaaggaactggatgagctgaagaaggaggtggcaatggat
gaccacaagctgtccttggatgagctgggccgcaaataccaagtggacctgtccaagggc
ctcaccaaccagcgggctcaggacgttctggctcgagatgggcccaacgccctcacacca
cctcccacaacccctgagtgggtcaagttctgccgtcagcttttcggggggttctccatc
ctgctgtggattggggctatcctctgcttcctggcctacggcatccaggctgccatggag
gatgaaccatccaacgacaatctatatctgggtgtggtgctggcagctgtggtcattgtc
actggctgcttctcctactaccaggaggccaagagctccaagatcatggattccttcaag
aacatggtacctcagcaagcccttgtgatccgggagggagagaagatgcagatcaacgca
gaggaagtggtggtgggagacctggtggaggtgaagggtggagaccgcgtccctgctgac
ctccggatcatctcttctcatggctgtaaggtggataactcatccttaacaggagagtcg
gagccccagacccgctcccccgagttcacccatgagaaccccctggagacccgcaatatc
tgtttcttctccaccaactgtgttgaaggcactgccaggggcattgtgattgccacagga
gaccggacggtgatgggccgcatagctactctcgcctcaggcctggaggttgggcggaca
cccatagcaatggagattgaacacttcatccagctgatcacaggggtcgctgtattcctg
ggggtctccttcttcgtgctctccctcatcctgggctacagctggctggaggcagtcatc
ttcctcatcggcatcatagtggccaacgtgcctgaggggcttctggccactgtcactgtg
tgcctgaccctgacagccaagcgcatggcacggaagaactgcctggtgaagaacctggag
gcggtggagacgctgggctccacgtccaccatctgctcggacaagacgggcaccctcacc
cagaaccgcatgaccgtcgcccacatgtggttcgacaaccaaatccatgaggctgacacc
accgaagatcagtctggggccacttttgacaaacgatcccctacgtggacggccctgtct
cgaattgctggtctctgcaaccgcgccgtcttcaaggcaggacaggagaacatctccgtg
tctaagcgggacacagctggtgatgcctctgagtcagctctgctcaagtgcattgagctc
tcctgtggctcagtgaggaaaatgagagacagaaaccccaaggtggcagagattcctttc
aactctaccaacaagtaccagctgtctatccacgagcgagaagacagcccccagagccac
gtgctggtgatgaagggggccccagagcgcattctggaccggtgctccaccatcctggtg
cagggcaaggagatcccgctcgacaaggagatgcaagatgcctttcaaaatgcctacatg
gagctggggggacttggggagcgtgtgctgggattctgtcaactgaatctgccatctgga
aagtttcctcggggcttcaaattcgacacggatgagctgaactttcccacggagaagctt
tgctttgtggggctcatgtctatgattgaccctccccgggctgctgtgccagatgctgtg
ggcaagtgccgaagcgcaggcatcaaggtgatcatggtaaccggggatcaccctatcaca
gccaaggccattgccaaaggcgtgggcatcatatcagagggtaacgagactgtggaggac
attgcagcccggctcaacattcccatgagtcaagtcaaccccagagaagccaaggcatgc
gtggtgcacggctctgacctgaaggacatgacatcggagcagctcgatgagatcctcaag
aaccacacagagatcgtctttgctcgaacgtctccccagcagaagctcatcattgtggag
ggatgtcagaggcagggagccattgtggccgtgacgggtgacggggtgaacgactcccct
gcattgaagaaggctgacattggcattgccatgggcatctctggctctgacgtctctaag
caggcagccgacatgatcctgctggatgacaactttgcctccatcgtcacgggggtggag
gagggccgcctgatctttgacaacttgaagaaatccatcgcctacaccctgaccagcaac
atccccgagatcacccccttcctgctgttcatcattgccaacatccccctacctctgggc
actgtgaccatcctttgcattgacctgggcacagatatggtccctgccatctccttggcc
tatgaggcagctgagagtgatatcatgaagcggcagccacgaaactcccagacggacaag
ctggtgaatgagaggctcatcagcatggcctacggacagatcgggatgatccaggcactg
ggtggcttcttcacctactttgtgatcctggcagagaacggtttcctgccatcacggcta
ctgggaatccgcctcgactgggatgaccggaccatgaatgatctggaggacagctatgga
caggagtggacctatgagcagcggaaggtggtggagttcacgtgccacacggcattcttt
gccagcatcgtggtggtgcagtgggctgacctcatcatctgcaagacccgccgcaactca
gtcttccagcagggcatgaagaacaagatcctgatttttgggctcctggaggagacggcg
ttggctgcctttctctcttactgcccaggcatgggtgtagccctccgcatgtacccgctc
aaagtcacctggtggttctgcgccttcccctacagcctcctcatcttcatctatgatgag
gtccgaaagctcatcctgcggcggtatcctggtggctgggtggagaaggagacatactac
tga

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