KEGG   Homo sapiens (human): 4791
Entry
4791              CDS       T01001                                 
Symbol
NFKB2, CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52
Name
(RefSeq) nuclear factor kappa B subunit 2
  KO
K04469  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04380  Osteoclast differentiation
hsa04625  C-type lectin receptor signaling pathway
hsa05134  Legionellosis
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05224  Breast cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06223  TNF signaling
nt06516  TNF signaling
  Element
N00505  CD40-NFKB signaling pathway
N00506  HTLV-1 Tax to CD40-NFKB signaling pathway
Disease
H00088  Common variable immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4791 (NFKB2)
   04064 NF-kappa B signaling pathway
    4791 (NFKB2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    4791 (NFKB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    4791 (NFKB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4791 (NFKB2)
   05203 Viral carcinogenesis
    4791 (NFKB2)
  09162 Cancer: specific types
   05224 Breast cancer
    4791 (NFKB2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    4791 (NFKB2)
   05169 Epstein-Barr virus infection
    4791 (NFKB2)
  09171 Infectious disease: bacterial
   05134 Legionellosis
    4791 (NFKB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    4791 (NFKB2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    4791 (NFKB2)
SSDB
Motif
Pfam: RHD_DNA_bind RHD_dimer Ank_2 Ank Ank_3 Ank_5 Ank_4 Death
Other DBs
NCBI-GeneID: 4791
NCBI-ProteinID: NP_001070962
OMIM: 164012
HGNC: 7795
Ensembl: ENSG00000077150
Pharos: Q00653(Tchem)
UniProt: Q00653
Structure
Position
10:102394110..102402529
AA seq 900 aa
MESCYNPGLDGIIEYDDFKLNSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGP
SHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGIC
AVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKE
LKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSV
RGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIE
RPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGS
GGAAGGYGGAGGGGSLGFFPSSLAYSPYQSGAGPMGCYPGGGGGAQMAATVPSRDSGEEA
AEPSAPSRTPQCEPQAPEMLQRAREYNARLFGLAQRSARALLDYGVTADARALLAGQRHL
LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT
SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEG
LYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRAN
VNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGP
EKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQNTMEPPLTPPSPAGPGLSLGDTALQNLEQ
LLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGL
EEGVRLLRGPETRDKLPSTAEVKEDSAYGSQSVEQEAEKLGPPPEPPGGLCHGHPQPQVH
NT seq 2703 nt   +upstreamnt  +downstreamnt
atggagagttgctacaacccaggtctggatggtattattgaatatgatgatttcaaattg
aactcctccattgtggaacccaaggagccagccccagaaacagctgatggcccctacctg
gtgatcgtggaacagcctaagcagagaggcttccgatttcgatatggctgtgaaggcccc
tcccatggaggactgcccggtgcctccagtgagaagggccgaaagacctatcccactgtc
aagatctgtaactacgagggaccagccaagatcgaggtggacctggtaacacacagtgac
ccacctcgtgctcatgcccacagtctggtgggcaagcaatgctcggagctggggatctgc
gccgtttctgtggggcccaaggacatgactgcccaatttaacaacctgggtgtcctgcat
gtgactaagaagaacatgatggggactatgatacaaaaacttcagaggcagcggctccgc
tctaggccccagggccttacggaggccgagcagcgggagctggagcaagaggccaaagaa
ctgaagaaggtgatggatctgagtatagtgcggctgcgcttctctgccttccttagagcc
agtgatggctccttctccctgcccctgaagccagtcatctcccagcccatccatgacagc
aaatctccgggggcatcaaacctgaagatttctcgaatggacaagacagcaggctctgtg
cggggtggagatgaagtttatctgctttgtgacaaggtgcagaaagatgacattgaggtt
cggttctatgaggatgatgagaatggatggcaggcctttggggacttctctcccacagat
gtgcataaacagtatgccattgtgttccggacacccccctatcacaagatgaagattgag
cggcctgtaacagtgtttctgcaactgaaacgcaagcgaggaggggacgtgtctgattcc
aaacagttcacctattaccctctggtggaagacaaggaagaggtgcagcggaagcggagg
aaggccttgcccaccttctcccagcccttcgggggtggctcccacatgggtggaggctct
gggggtgcagccgggggctacggaggagctggaggaggtggcagcctcggtttcttcccc
tcctccctggcctacagcccctaccagtccggcgcgggccccatgggctgctacccggga
ggcgggggcggggcgcagatggccgccacggtgcccagcagggactccggggaggaagcc
gcggagccgagcgccccctccaggaccccccagtgcgagccgcaggccccggagatgctg
cagcgagctcgagagtacaacgcgcgcctgttcggcctggcgcagcgcagcgcccgagcc
ctactcgactacggcgtcaccgcggacgcgcgcgcgctgctggcgggacagcgccacctg
ctgacggcgcaggacgagaacggagacacaccactgcacctagccatcatccacgggcag
accagtgtcattgagcagatagtctatgtcatccaccacgcccaggacctcggcgttgtc
aacctcaccaaccacctgcaccagacgcccctgcacctggcggtgatcacggggcagacg
agtgtggtgagctttctgctgcgggtaggtgcagacccagctctgctggatcggcatgga
gactcagccatgcatctggcgctgcgggcaggcgctggtgctcctgagctgctgcgtgca
ctgcttcagagtggagctcctgctgtgccccagctgttgcatatgcctgactttgaggga
ctgtatccagtacacctggcggtccgagcccgaagccctgagtgcctggatctgctggtg
gacagtggggctgaagtggaggccacagagcggcaggggggacgaacagccttgcatcta
gccacagagatggaggagctggggttggtcacccatctggtcaccaagctccgggccaac
gtgaacgctcgcacctttgcgggaaacacacccctgcacctggcagctggactggggtac
ccgaccctcacccgcctccttctgaaggctggtgctgacatccatgctgaaaacgaggag
cccctgtgcccactgccttcaccccctacctctgatagcgactcggactctgaagggcct
gagaaggacacccgaagcagcttccggggccacacgcctcttgacctcacttgcagcacc
aaggtgaagaccttgctgctaaatgctgctcagaacaccatggagccacccctgaccccg
cccagcccagcagggccgggactgtcacttggtgatacagctctgcagaacctggagcag
ctgctagacgggccagaagcccagggcagctgggcagagctggcagagcgtctggggctg
cgcagcctggtagacacgtaccgacagacaacctcacccagtggcagcctcctgcgcagc
tacgagctggctggcggggacctggcaggtctactggaggccctgtctgacatgggccta
gaggagggagtgaggctgctgaggggtccagaaacccgagacaagctgcccagcacagca
gaggtgaaggaagacagtgcgtacgggagccagtcagtggagcaggaggcagagaagctg
ggcccaccccctgagccaccaggagggctctgccacgggcacccccagcctcaggtgcac
tga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
   PHAROS (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (34)   
   RefSeq(nuc) (6)   
   GenBank (14)   
   EMBL (14)   
3D Structure (9)   
   PDB (9)   
Protein domain (8)   
   Pfam (8)   
All databases (104)   

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