KEGG   Homo sapiens (human): 54904
Entry
54904             CDS       T01001                                 

Gene name
NSD3, KMT3F, KMT3G, WHISTLE, WHSC1L1, pp14328
Definition
(RefSeq) nuclear receptor binding SET domain protein 3
  KO
K11425  [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase [EC:2.1.1.370 2.1.1.371]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00310  Lysine degradation
hsa01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    54904 (NSD3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    54904 (NSD3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.370  [histone H3]-lysine4 N-dimethyltransferase
     54904 (NSD3)
    2.1.1.371  [histone H3]-lysine27 N-dimethyltransferase
     54904 (NSD3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     54904 (NSD3)
SSDB
Motif
Pfam: PWWP C5HCH SET AWS PHD zf-HC5HC2H_2 zf-HC5HC2H
Other DBs
NCBI-GeneID: 54904
NCBI-ProteinID: NP_075447
OMIM: 607083
HGNC: 12767
Ensembl: ENSG00000147548
Vega: OTTHUMG00000165115
Pharos: Q9BZ95(Tbio)
UniProt: Q9BZ95
Structure
PDB: 

Position
8p11.23
AA seq 1437 aa
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYP
ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR
PHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPRE
EPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI
NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR
RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLP
ASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIK
KEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSD
LQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVR
KFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLV
SSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAE
LMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHY
KQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYV
EGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANK
VIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFT
KRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFY
MLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFN
YNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMH
EDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEF
CPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE
NT seq 4314 nt   +upstreamnt  +downstreamnt
atggatttctctttctctttcatgcaagggatcatgggaaacacaattcagcaaccacct
caactcattgactccgccaacatccgtcaggaggatgcctttgataacaacagtgacatt
gctgaagatggtggccagacaccatatgaagctactttgcagcaaggctttcagtaccca
gctacaacagaagatcttcctccactcacaaatgggtatccatcatcaatcagtgtgtat
gaaactcaaaccaaataccagtcatataatcagtatcctaatgggtcagccaatggcttt
ggtgcagttagaaactttagccccactgactattatcattcagaaattccaaacacaaga
ccacatgaaattctggaaaaaccttcccctccacagccaccacctcctccttcggtacca
caaactgtgattccaaagaagactggctcacctgaaattaaactaaaaataaccaaaact
atccagaatggcagggaattgtttgagtcttccctttgtggagaccttttaaatgaagta
caggcaagtgagcacacgaaatcaaagcatgaaagcagaaaagaaaagaggaaaaaaagc
aacaagcatgactcatcaagatctgaagagcgcaagtcacacaaaatccccaaattagaa
ccagaggaacaaaatagaccaaatgagagggttgacactgtatcagaaaaaccaagggaa
gaaccagtactaaaagaggaagccccagttcagccaatactatcttctgttccaacaacg
gaagtgtccactggtgttaagtttcaggttggcgatcttgtgtggtccaaggtgggaacc
tatccttggtggccttgtatggtttcaagtgatccccagcttgaggttcatactaaaatt
aacacaagaggtgcccgagaatatcatgtccagttttttagcaaccagccagagagggcg
tgggttcatgaaaaacgggtacgagagtataaaggtcataaacagtatgaagaattactg
gctgaggcaaccaaacaagccagcaatcactctgagaaacaaaagattcggaaaccccga
cctcagagagaacgtgctcagtgggatattggcattgcccatgcagagaaagcattgaaa
atgactcgagaagaaagaatagaacagtatacttttatttacattgataaacagcctgaa
gaggctttatcccaagcaaaaaagagtgttgcctccaaaaccgaagttaaaaaaacccga
cgaccaagatctgtgctgaatactcagccagaacagaccaatgcaggggaggtggcctcc
tcactctcaagtactgaaattcggagacatagccagaggcggcacacaagtgcggaagag
gaagagccaccgcctgttaaaatagcctggaaaactgcggcagcaaggaaatccttacca
gcttccattacgatgcacaaagggagcctggatttgcagaagtgtaacatgtctccagtt
gtgaaaattgaacaagtgtttgctcttcagaatgctacaggggatgggaaatttatcgat
caatttgtttattcaacaaagggaattggtaacaaaacagaaataagtgtcagggggcaa
gacaggcttataatttctacaccaaaccagagaaatgaaaagccaacgcagagtgtatca
tctcctgaagcaacatctggttctacaggctcagtagaaaagaagcaacagagaagatca
attagaactcgttctgaatcagagaaatccactgaggttgtgccaaagaagaagatcaaa
aaggagcaggttgaaacagttcctcaggctacagtgaagactggattacagaaaggtgcc
agcgagatttcagattcctgtaaacctctaaagaaaaggagtcgcgcctcaactgatgta
gaaatgactagttcagcatacagagacacatctgactccgattctagaggactgagtgac
ctgcaggtaggctttggaaagcaagtagatagcccttcagctactgcagatgcagacgtt
tctgatgtgcagtccatggattcaagtttgtcgagaagaggcactggaatgagtaagaag
gacactgtatgtcagatttgtgaaagctctggtgactctctgattccttgtgagggagag
tgctgcaaacactttcacctggagtgcctgggattggcatcacttcctgatagcaagttc
atctgcatggaatgtaaaactgggcagcacccatgtttttcgtgtaaagtgtctggtaaa
gatgtgaagcgttgttctgttggtgcttgtgggaaattttatcatgaagcctgtgtccgc
aaattccccactgccatctttgaatcaaaaggattccgctgtcctcagcactgctgctct
gcctgctctatggagaaagatatccacaaagcaagtaaaggccgcatgatgagatgttta
agatgtccagttgcctatcactctggagatgcttgcattgcggccggaagcatgttagta
tcctcctacattctcatctgtagtaatcattccaaacggagcagtaattcttctgctgta
aatgtaggcttttgtttcgtttgtgccagagggctgatagttcaggaccattcagacccc
atgttcagttcatatgcctataagtcccactacctactgaatgaatcaaatcgtgctgag
ttgatgaaattacctatgattccttcttcgtcagcttccaaaaagaaatgtgagaaaggt
ggaagattgctctgctgtgaatcgtgcccagcttccttccacccggaatgcctaagcata
gaaatgccagaaggctgctggaattgtaatgactgtaaagctggcaagaaactacattac
aagcagattgtttgggtcaaattgggaaattacagatggtggccagcagagatctgcaac
cccaggtctgtgccactgaacatccagggccttaaacatgacttgggggacttccctgta
ttcttctttggttctcatgactactactgggtacaccagggcagagtgttcccttatgtt
gaaggagacaaaagctttgctgaagggcagactagtattaacaagaccttcaaaaaggca
ctggaagaagctgcaaaacgtttccaggaattgaaagcacaaagagaaagtaaagaagcc
ctagagattgaaaaaaactcaagaaaaccccctccctacaaacacatcaaagctaacaaa
gtaataggaaaggtgcagatccaggttgctgacctgtcagagattccccgctgtaactgc
aagccagctgatgaaaacccttgtggcttggaatcggagtgcctgaacagaatgttgcag
tatgaatgccacccgcaggtgtgcccagctggagatcgttgtcagaaccagtgctttaca
aagagactataccctgatgcagagatcatcaaaacggagcggagaggctggggcctcagg
accaaaaggagcattaagaagggtgaatttgtaaatgaatacgtcggtgaattaattgat
gaagaagaatgcagattgcgaatcaagcgagcccacgagaacagtgtaactaatttttat
atgttaactgttaccaaggaccgtataattgatgccggcccaaaaggaaattattctcgc
ttcatgaaccacagttgtaatcccaactgtgaaacacaaaagtggacagtgaatggagat
gttcgagtgggactatttgctctctgtgatattcctgcagggatggagttaacatttaat
tataacctagattgtctgggcaacggcagaacggagtgccactgtggagcagataactgc
agtggttttctaggagtgcggccaaagtcggcatgtgcgtcaacaaatgaagagaaggca
aaaaatgctaagttaaaacagaagagacgaaagatcaaaacagaaccaaagcagatgcat
gaagattactgttttcaatgtggagatggtggagagctggtcatgtgtgacaaaaaagac
tgtcccaaagcataccacctcctatgccttaacctgactcagccaccatatggaaagtgg
gagtgtccgtggcatcagtgcgatgagtgcagcagtgcagctgtttccttctgtgaattc
tgtccacattcattttgtaaagatcatgaaaagggggccctggttccctctgcactggaa
ggccgcctctgctgctcggaacatgaccccatggctcctgtgtcaccagaatactggagc
aagataaaatgtaaatgggaatcacaagatcatggagaagaagtaaaagaataa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (52)   
   RefSeq(nuc) (2)   
   GenBank (25)   
   EMBL (25)   
Protein domain (7)   
   Pfam (7)   
All databases (108)   

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