KEGG   Homo sapiens (human): 5579Help
Entry
5579              CDS       T01001                                 

Gene name
PRKCB, PKC-beta, PKCB, PKCI(2), PKCbeta, PRKCB1, PRKCB2
Definition
(RefSeq) protein kinase C beta
  KO
K19662  classical protein kinase C beta type [EC:2.7.11.13]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04062  Chemokine signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04150  mTOR signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04310  Wnt signaling pathway
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion
hsa04540  Gap junction
hsa04650  Natural killer cell mediated cytotoxicity
hsa04662  B cell receptor signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04670  Leukocyte transendothelial migration
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04730  Long-term depression
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04973  Carbohydrate digestion and absorption
hsa05031  Amphetamine addiction
hsa05032  Morphine addiction
hsa05140  Leishmaniasis
hsa05143  African trypanosomiasis
hsa05146  Amoebiasis
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05214  Glioma
hsa05223  Non-small cell lung cancer
hsa05225  Hepatocellular carcinoma
hsa05231  Choline metabolism in cancer
Network
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00227  TGFA-EGFR-PLCG-PKC signaling pathway
N00228  TGFA-overexpression to PLCG-PKC signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00414  HCMV US27 to CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
Drug target
Enzastaurin hydrochloride: D04014
Midostaurin: D05029
Safingol: D05784
Safingol hydrochloride: D05785
Tigilanol tiglate: D11191
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    5579 (PRKCB)
   04015 Rap1 signaling pathway
    5579 (PRKCB)
   04010 MAPK signaling pathway
    5579 (PRKCB)
   04012 ErbB signaling pathway
    5579 (PRKCB)
   04310 Wnt signaling pathway
    5579 (PRKCB)
   04370 VEGF signaling pathway
    5579 (PRKCB)
   04064 NF-kappa B signaling pathway
    5579 (PRKCB)
   04066 HIF-1 signaling pathway
    5579 (PRKCB)
   04020 Calcium signaling pathway
    5579 (PRKCB)
   04070 Phosphatidylinositol signaling system
    5579 (PRKCB)
   04071 Sphingolipid signaling pathway
    5579 (PRKCB)
   04150 mTOR signaling pathway
    5579 (PRKCB)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5579 (PRKCB)
   04540 Gap junction
    5579 (PRKCB)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    5579 (PRKCB)
   04662 B cell receptor signaling pathway
    5579 (PRKCB)
   04666 Fc gamma R-mediated phagocytosis
    5579 (PRKCB)
   04670 Leukocyte transendothelial migration
    5579 (PRKCB)
   04062 Chemokine signaling pathway
    5579 (PRKCB)
  09152 Endocrine system
   04911 Insulin secretion
    5579 (PRKCB)
   04912 GnRH signaling pathway
    5579 (PRKCB)
   04921 Oxytocin signaling pathway
    5579 (PRKCB)
   04918 Thyroid hormone synthesis
    5579 (PRKCB)
   04919 Thyroid hormone signaling pathway
    5579 (PRKCB)
   04928 Parathyroid hormone synthesis, secretion and action
    5579 (PRKCB)
   04916 Melanogenesis
    5579 (PRKCB)
   04925 Aldosterone synthesis and secretion
    5579 (PRKCB)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    5579 (PRKCB)
  09154 Digestive system
   04970 Salivary secretion
    5579 (PRKCB)
   04971 Gastric acid secretion
    5579 (PRKCB)
   04972 Pancreatic secretion
    5579 (PRKCB)
   04973 Carbohydrate digestion and absorption
    5579 (PRKCB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5579 (PRKCB)
   04961 Endocrine and other factor-regulated calcium reabsorption
    5579 (PRKCB)
  09156 Nervous system
   04724 Glutamatergic synapse
    5579 (PRKCB)
   04727 GABAergic synapse
    5579 (PRKCB)
   04725 Cholinergic synapse
    5579 (PRKCB)
   04728 Dopaminergic synapse
    5579 (PRKCB)
   04726 Serotonergic synapse
    5579 (PRKCB)
   04720 Long-term potentiation
    5579 (PRKCB)
   04730 Long-term depression
    5579 (PRKCB)
   04723 Retrograde endocannabinoid signaling
    5579 (PRKCB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5579 (PRKCB)
  09159 Environmental adaptation
   04713 Circadian entrainment
    5579 (PRKCB)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    5579 (PRKCB)
   05231 Choline metabolism in cancer
    5579 (PRKCB)
   05206 MicroRNAs in cancer
    5579 (PRKCB)
   05205 Proteoglycans in cancer
    5579 (PRKCB)
  09162 Cancers: Specific types
   05225 Hepatocellular carcinoma
    5579 (PRKCB)
   05214 Glioma
    5579 (PRKCB)
   05223 Non-small cell lung cancer
    5579 (PRKCB)
  09165 Substance dependence
   05031 Amphetamine addiction
    5579 (PRKCB)
   05032 Morphine addiction
    5579 (PRKCB)
  09167 Endocrine and metabolic diseases
   04931 Insulin resistance
    5579 (PRKCB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5579 (PRKCB)
  09172 Infectious diseases: Viral
   05170 Human immunodeficiency virus 1 infection
    5579 (PRKCB)
   05164 Influenza A
    5579 (PRKCB)
   05161 Hepatitis B
    5579 (PRKCB)
   05163 Human cytomegalovirus infection
    5579 (PRKCB)
  09174 Infectious diseases: Parasitic
   05146 Amoebiasis
    5579 (PRKCB)
   05140 Leishmaniasis
    5579 (PRKCB)
   05143 African trypanosomiasis
    5579 (PRKCB)
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5579 (PRKCB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5579 (PRKCB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     5579 (PRKCB)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   5579 (PRKCB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr C1_1 C2 Pkinase_C C1_2 Kinase-like Haspin_kinase CEP76-C2 APH
Motif
Other DBs
NCBI-GeneID: 5579
NCBI-ProteinID: NP_997700
OMIM: 176970
HGNC: 9395
Ensembl: ENSG00000166501
Vega: OTTHUMG00000131615
Pharos: P05771(Tchem)
UniProt: P05771
Structure
PDB: 

Position
16p12.2-p12.1
AA seq 671 aa AA seqDB search
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
NT seq 2016 nt NT seq  +upstreamnt  +downstreamnt
atggctgacccggctgcggggccgccgccgagcgagggcgaggagagcaccgtgcgcttc
gcccgcaaaggcgccctccggcagaagaacgtgcatgaggtcaagaaccacaaattcacc
gcccgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctggggcttc
gggaagcagggattccagtgccaagtttgctgctttgtggtgcacaagcggtgccatgaa
tttgtcacattctcctgccctggcgctgacaagggtccagcctccgatgacccccgcagc
aaacacaagtttaagatccacacgtactccagccccacgttttgtgaccactgtgggtca
ctgctgtatggactcatccaccaggggatgaaatgtgacacctgcatgatgaatgtgcac
aagcgctgcgtgatgaatgttcccagcctgtgtggcacggaccacacggagcgccgcggc
cgcatctacatccaggcccacatcgacagggacgtcctcattgtcctcgtaagagatgct
aaaaaccttgtacctatggaccccaatggcctgtcagatccctacgtaaaactgaaactg
attcccgatcccaaaagtgagagcaaacagaagaccaaaaccatcaaatgctccctcaac
cctgagtggaatgagacatttagatttcagctgaaagaatcggacaaagacagaagactg
tcagtagagatttgggattgggatttgaccagcaggaatgacttcatgggatctttgtcc
tttgggatttctgaacttcagaaagccagtgttgatggctggtttaagttactgagccag
gaggaaggcgagtacttcaatgtgcctgtgccaccagaaggaagtgaggccaatgaagaa
ctgcggcagaaatttgagagggccaagatcagtcagggaaccaaggtcccggaagaaaag
acgaccaacactgtctccaaatttgacaacaatggcaacagagaccggatgaaactgacc
gattttaacttcctaatggtgctggggaaaggcagctttggcaaggtcatgctttcagaa
cgaaaaggcacagatgagctctatgctgtgaagatcctgaagaaggacgttgtgatccaa
gatgatgacgtggagtgcactatggtggagaagcgggtgttggccctgcctgggaagccg
cccttcctgacccagctccactcctgcttccagaccatggaccgcctgtactttgtgatg
gagtacgtgaatgggggcgacctcatgtatcacatccagcaagtcggccggttcaaggag
ccccatgctgtattttacgctgcagaaattgccatcggtctgttcttcttacagagtaag
ggcatcatttaccgtgacctaaaacttgacaacgtgatgctcgattctgagggacacatc
aagattgccgattttggcatgtgtaaggaaaacatctgggatggggtgacaaccaagaca
ttctgtggcactccagactacatcgcccccgagataattgcttatcagccctatgggaag
tccgtggattggtgggcatttggagtcctgctgtatgaaatgttggctgggcaggcaccc
tttgaaggggaggatgaagatgaactcttccaatccatcatggaacacaacgtagcctat
cccaagtctatgtccaaggaagctgtggccatctgcaaagggctgatgaccaaacaccca
ggcaaacgtctgggttgtggacctgaaggcgaacgtgatatcaaagagcatgcatttttc
cggtatattgattgggagaaacttgaacgcaaagagatccagcccccttataagccaaaa
gctagagacaagagagacacctccaacttcgacaaagagttcaccagacagcctgtggaa
ctgacccccactgataaactcttcatcatgaacttggaccaaaatgaatttgctggcttc
tcttatactaacccagagtttgtcattaatgtgtag

DBGET integrated database retrieval system