KEGG   ORTHOLOGY: K19662
Entry
K19662                      KO                                     

Symbol
PRKCB
Name
classical protein kinase C beta type [EC:2.7.11.13]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04070  Phosphatidylinositol signaling system
map04071  Sphingolipid signaling pathway
map04150  mTOR signaling pathway
map04270  Vascular smooth muscle contraction
map04310  Wnt signaling pathway
map04370  VEGF signaling pathway
map04510  Focal adhesion
map04540  Gap junction
map04613  Neutrophil extracellular trap formation
map04650  Natural killer cell mediated cytotoxicity
map04662  B cell receptor signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04670  Leukocyte transendothelial migration
map04713  Circadian entrainment
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04730  Long-term depression
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04919  Thyroid hormone signaling pathway
map04921  Oxytocin signaling pathway
map04925  Aldosterone synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04929  GnRH secretion
map04931  Insulin resistance
map04933  AGE-RAGE signaling pathway in diabetic complications
map04935  Growth hormone synthesis, secretion and action
map04960  Aldosterone-regulated sodium reabsorption
map04961  Endocrine and other factor-regulated calcium reabsorption
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04973  Carbohydrate digestion and absorption
map05017  Spinocerebellar ataxia
map05022  Pathways of neurodegeneration - multiple diseases
map05031  Amphetamine addiction
map05032  Morphine addiction
map05140  Leishmaniasis
map05143  African trypanosomiasis
map05146  Amoebiasis
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05214  Glioma
map05223  Non-small cell lung cancer
map05225  Hepatocellular carcinoma
map05231  Choline metabolism in cancer
map05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04012 ErbB signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04014 Ras signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04015 Rap1 signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04310 Wnt signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04370 VEGF signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04064 NF-kappa B signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04066 HIF-1 signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04020 Calcium signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04070 Phosphatidylinositol signaling system
    K19662  PRKCB; classical protein kinase C beta type
   04071 Sphingolipid signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04150 mTOR signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K19662  PRKCB; classical protein kinase C beta type
   04540 Gap junction
    K19662  PRKCB; classical protein kinase C beta type
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K19662  PRKCB; classical protein kinase C beta type
   04650 Natural killer cell mediated cytotoxicity
    K19662  PRKCB; classical protein kinase C beta type
   04662 B cell receptor signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04666 Fc gamma R-mediated phagocytosis
    K19662  PRKCB; classical protein kinase C beta type
   04670 Leukocyte transendothelial migration
    K19662  PRKCB; classical protein kinase C beta type
   04062 Chemokine signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
  09152 Endocrine system
   04911 Insulin secretion
    K19662  PRKCB; classical protein kinase C beta type
   04929 GnRH secretion
    K19662  PRKCB; classical protein kinase C beta type
   04912 GnRH signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04921 Oxytocin signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04935 Growth hormone synthesis, secretion and action
    K19662  PRKCB; classical protein kinase C beta type
   04918 Thyroid hormone synthesis
    K19662  PRKCB; classical protein kinase C beta type
   04919 Thyroid hormone signaling pathway
    K19662  PRKCB; classical protein kinase C beta type
   04928 Parathyroid hormone synthesis, secretion and action
    K19662  PRKCB; classical protein kinase C beta type
   04916 Melanogenesis
    K19662  PRKCB; classical protein kinase C beta type
   04925 Aldosterone synthesis and secretion
    K19662  PRKCB; classical protein kinase C beta type
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K19662  PRKCB; classical protein kinase C beta type
  09154 Digestive system
   04970 Salivary secretion
    K19662  PRKCB; classical protein kinase C beta type
   04971 Gastric acid secretion
    K19662  PRKCB; classical protein kinase C beta type
   04972 Pancreatic secretion
    K19662  PRKCB; classical protein kinase C beta type
   04973 Carbohydrate digestion and absorption
    K19662  PRKCB; classical protein kinase C beta type
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K19662  PRKCB; classical protein kinase C beta type
   04961 Endocrine and other factor-regulated calcium reabsorption
    K19662  PRKCB; classical protein kinase C beta type
  09156 Nervous system
   04724 Glutamatergic synapse
    K19662  PRKCB; classical protein kinase C beta type
   04727 GABAergic synapse
    K19662  PRKCB; classical protein kinase C beta type
   04725 Cholinergic synapse
    K19662  PRKCB; classical protein kinase C beta type
   04728 Dopaminergic synapse
    K19662  PRKCB; classical protein kinase C beta type
   04726 Serotonergic synapse
    K19662  PRKCB; classical protein kinase C beta type
   04720 Long-term potentiation
    K19662  PRKCB; classical protein kinase C beta type
   04730 Long-term depression
    K19662  PRKCB; classical protein kinase C beta type
   04723 Retrograde endocannabinoid signaling
    K19662  PRKCB; classical protein kinase C beta type
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K19662  PRKCB; classical protein kinase C beta type
  09159 Environmental adaptation
   04713 Circadian entrainment
    K19662  PRKCB; classical protein kinase C beta type
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K19662  PRKCB; classical protein kinase C beta type
   05206 MicroRNAs in cancer
    K19662  PRKCB; classical protein kinase C beta type
   05205 Proteoglycans in cancer
    K19662  PRKCB; classical protein kinase C beta type
   05207 Chemical carcinogenesis - receptor activation
    K19662  PRKCB; classical protein kinase C beta type
   05231 Choline metabolism in cancer
    K19662  PRKCB; classical protein kinase C beta type
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K19662  PRKCB; classical protein kinase C beta type
   05214 Glioma
    K19662  PRKCB; classical protein kinase C beta type
   05223 Non-small cell lung cancer
    K19662  PRKCB; classical protein kinase C beta type
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K19662  PRKCB; classical protein kinase C beta type
   05161 Hepatitis B
    K19662  PRKCB; classical protein kinase C beta type
   05171 Coronavirus disease - COVID-19
    K19662  PRKCB; classical protein kinase C beta type
   05164 Influenza A
    K19662  PRKCB; classical protein kinase C beta type
   05163 Human cytomegalovirus infection
    K19662  PRKCB; classical protein kinase C beta type
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K19662  PRKCB; classical protein kinase C beta type
   05140 Leishmaniasis
    K19662  PRKCB; classical protein kinase C beta type
   05143 African trypanosomiasis
    K19662  PRKCB; classical protein kinase C beta type
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    K19662  PRKCB; classical protein kinase C beta type
   05022 Pathways of neurodegeneration - multiple diseases
    K19662  PRKCB; classical protein kinase C beta type
  09165 Substance dependence
   05031 Amphetamine addiction
    K19662  PRKCB; classical protein kinase C beta type
   05032 Morphine addiction
    K19662  PRKCB; classical protein kinase C beta type
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K19662  PRKCB; classical protein kinase C beta type
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K19662  PRKCB; classical protein kinase C beta type
   04933 AGE-RAGE signaling pathway in diabetic complications
    K19662  PRKCB; classical protein kinase C beta type
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K19662  PRKCB; classical protein kinase C beta type
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K19662  PRKCB; classical protein kinase C beta type
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     K19662  PRKCB; classical protein kinase C beta type
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   K19662  PRKCB; classical protein kinase C beta type
Other DBs
GO: 0004697
Genes
HSA: 5579(PRKCB)
PTR: 453993(PRKCB)
PPS: 100970296(PRKCB)
GGO: 101150691(PRKCB)
PON: 100439900(PRKCB)
NLE: 100590939(PRKCB)
MCC: 701195(PRKCB)
MCF: 102116992(PRKCB)
CSAB: 103229829(PRKCB)
CATY: 105586076(PRKCB)
PANU: 101009865(PRKCB)
RRO: 104665907(PRKCB)
RBB: 108538857(PRKCB)
TFN: 117087485(PRKCB)
PTEH: 111524197(PRKCB)
CJC: 100410136(PRKCB)
SBQ: 101039384(PRKCB)
MMUR: 105879718(PRKCB)
MMU: 18751(Prkcb)
MCAL: 110297826(Prkcb)
MPAH: 110320075(Prkcb)
RNO: 25023(Prkcb)
MCOC: 116102917(Prkcb)
MUN: 110559612(Prkcb)
CGE: 100760922(Prkcb)
PLEU: 114692203(Prkcb)
NGI: 103746928(Prkcb)
HGL: 101722702(Prkcb)
CCAN: 109683738(Prkcb)
OCU: 100037719(PRKCB)
TUP: 102469271(PRKCB)
CFA: 489968(PRKCB)
VVP: 112908300(PRKCB)
VLG: 121487652(PRKCB)
AML: 100478007(PRKCB)
UMR: 103668895(PRKCB)
UAH: 113267584(PRKCB)
ORO: 101380879(PRKCB)
ELK: 111162208
MPUF: 101680372(PRKCB)
MLX: 117999123(PRKCB)
FCA: 101088970(PRKCB)
PYU: 121019369(PRKCB)
PBG: 122471545(PRKCB)
PTG: 102952814(PRKCB)
PPAD: 109255537(PRKCB)
AJU: 106970449(PRKCB)
HHV: 120233260(PRKCB)
BTA: 282325(PRKCB)
BOM: 102274116(PRKCB)
BIU: 109578560(PRKCB)
BBUB: 102407189(PRKCB)
CHX: 102172114(PRKCB)
OAS: 101118410(PRKCB)
ODA: 120876193(PRKCB)
CCAD: 122433081(PRKCB)
SSC: 100522792(PRKCB)
CFR: 102511859(PRKCB)
CBAI: 105073669(PRKCB)
CDK: 105094833(PRKCB)
BACU: 103012542(PRKCB)
LVE: 103090549(PRKCB)
OOR: 101277002(PRKCB)
DLE: 111182232(PRKCB)
PCAD: 102974383(PRKCB)
ECB: 100069215(PRKCB)
EPZ: 103558165(PRKCB)
EAI: 106823831(PRKCB)
MYB: 102243136(PRKCB)
MYD: 102757004(PRKCB)
MMYO: 118655815(PRKCB)
MNA: 107544745(PRKCB)
HAI: 109386578(PRKCB)
DRO: 112304830(PRKCB)
SHON: 119004000(PRKCB)
AJM: 119043241(PRKCB)
MMF: 118641370(PRKCB)
PALE: 102880663(PRKCB)
PGIG: 120584534(PRKCB)
RAY: 107516091(PRKCB)
MJV: 108385666(PRKCB)
TOD: 119241818(PRKCB)
LAV: 100672078(PRKCB)
TMU: 101356454
MDO: 100013346(PRKCB)
SHR: 100924022(PRKCB)
PCW: 110214622(PRKCB)
OAA: 100074181(PRKCB)
GGA: 416567(PRKCB)
PCOC: 116237359(PRKCB)
MGP: 100538953(PRKCB)
CJO: 107320755(PRKCB)
NMEL: 110405777(PRKCB)
APLA: 101799551(PRKCB)
ACYG: 106046027(PRKCB)
TGU: 100227442(PRKCB)
LSR: 110479547(PRKCB)
SCAN: 103817801(PRKCB)
PMOA: 120513152(PRKCB)
GFR: 102041922(PRKCB)
FAB: 101820883(PRKCB)
PHI: 102104824(PRKCB)
PMAJ: 107211235(PRKCB)
CCAE: 111936199(PRKCB)
CCW: 104684988(PRKCB)
ETL: 114064309(PRKCB)
FPG: 101912011(PRKCB)
FCH: 102047370(PRKCB)
CLV: 102090291(PRKCB)
EGZ: 104134542(PRKCB)
NNI: 104015276(PRKCB)
ACUN: 113485934(PRKCB)
PADL: 103921911(PRKCB)
AAM: 106486190(PRKCB)
AROW: 112975652(PRKCB)
NPD: 112959897(PRKCB)
DNE: 112985376(PRKCB)
ASN: 102368878(PRKCB)
AMJ: 102572486(PRKCB)
CPOO: 109314792(PRKCB)
GGN: 109294289(PRKCB)
PSS: 102449325(PRKCB)
CMY: 102942074(PRKCB)
CPIC: 101951581(PRKCB)
TST: 117884391(PRKCB)
CABI: 116818245(PRKCB)
PVT: 110085019(PRKCB)
PMUR: 107285104(PRKCB)
TSR: 106544999
PGUT: 117667323(PRKCB)
PMUA: 114583925(PRKCB)
ZVI: 118092573(PRKCB)
GJA: 107106337
XTR: 100038043(prkcb)
NPR: 108791355(PRKCB)
DRE: 100006675(prkcba) 393953(prkcbb)
AMEX: 103025973 103036012(prkcb)
TRU: 101065234 101079815(prkcb)
LCO: 104917655(prkcb) 104929965
NCC: 104965314 104967427(prkcb)
CGOB: 115012036(prkcb) 115017865
PLEP: 121941709 121957205(prkcbb)
PFLV: 114566211 114569627(prkcb)
MSAM: 119885905(prkcbb) 119898769
MZE: 101465488(prkcb) 101478005
ONL: 100703205 100710878(prkcb)
OAU: 116311412(prkcbb) 116312377
OLA: 101161464 105353642(prkcb)
XMA: 102228928 102235758(prkcb)
XCO: 114145501 114159895(prkcb)
XHE: 116719433 116735978(prkcb)
PRET: 103462977 103468586(prkcb)
CVG: 107086424 107093530(prkcb)
CTUL: 119780330(prkcbb) 119783658
NFU: 107376405(prkcb) 107388621
KMR: 108230652 108236219(prkcbb)
CSEM: 103383625 103393234(prkcb)
LCF: 108881079(prkcb) 108888464
SDU: 111216674 111230195(prkcb)
XGL: 120788166(prkcbb) 120799866
BPEC: 110153511 110155785(prkcb)
MALB: 109958847(prkcb) 109968203
SNH: 120042471
ELS: 105009402 105030718(prkcb)
LOC: 102689943(prkcb)
LCM: 102364971(PRKCB)
CMK: 103186617(prkcb)
RTP: 109913788
SKO: 100370447
DSI: Dsimw501_GD11232(Dsim_GD11232)
DSR: 110179095
DPE: 6590351
DWI: 6640135
DHE: 111592669
MDE: 101894312
LCQ: 111684370
CBR: CBG21094
GAE: 121380057
EGL: EGR_03545
NVE: 5516896
 » show all
Reference
  Authors
Saijo K, Mecklenbrauker I, Santana A, Leitger M, Schmedt C, Tarakhovsky A
  Title
Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha.
  Journal
J Exp Med 195:1647-52 (2002)
DOI:10.1084/jem.20020408
  Sequence
[hsa:5579]
Reference
PMID:3666134
  Authors
Kubo K, Ohno S, Suzuki K
  Title
Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences.
  Journal
FEBS Lett 223:138-42 (1987)
DOI:10.1016/0014-5793(87)80524-0
Reference
PMID:3755548
  Authors
Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A
  Title
Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.
  Journal
Science 233:859-66 (1986)
DOI:10.1126/science.3755548
  Sequence
[hsa:5579]

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