KEGG   Homo sapiens (human): 558
Entry
558               CDS       T01001                                 
Symbol
AXL, ARK, JTK11, Tyro7, UFO
Name
(RefSeq) AXL receptor tyrosine kinase
  KO
K05115  AXL receptor tyrosine kinase [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
Drug target
Amuvatinib (DG01916): D09864 D09865
Batiraxcept: D12271
Bemcentinib: D11438
Cabozantinib (DG01670): D10062 D10095<JP/US>
Dubermatinib (DG03093): D11732 D11733
Mecbotamab: D12219
Mecbotamab vedotin: D12220
Merestinib: D11763
Mipasetamab: D12279
Mipasetamab uzoptirine: D12280
Sitravatinib (DG03045): D11140 D11541
Zanzalintinib: D12650
Zanzalintinib fumarate: D12651
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    558 (AXL)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    558 (AXL)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     558 (AXL)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  AXL family
   558 (AXL)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase fn3 Ig_3 Ig_2 I-set ig V-set C2-set_2 Pkinase_fungal C1-set APH DUF2627 DUF4381
Other DBs
NCBI-GeneID: 558
NCBI-ProteinID: NP_068713
OMIM: 109135
HGNC: 905
Ensembl: ENSG00000167601
UniProt: P30530
Structure
Position
19:41219223..41261766
AA seq 894 aa
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
NT seq 2685 nt   +upstreamnt  +downstreamnt
atggcgtggcggtgccccaggatgggcagggtcccgctggcctggtgcttggcgctgtgc
ggctgggcgtgcatggcccccaggggcacgcaggctgaagaaagtcccttcgtgggcaac
ccagggaatatcacaggtgcccggggactcacgggcacccttcggtgtcagctccaggtt
cagggagagccccccgaggtacattggcttcgggatggacagatcctggagctcgcggac
agcacccagacccaggtgcccctgggtgaggatgaacaggatgactggatagtggtcagc
cagctcagaatcacctccctgcagctttccgacacgggacagtaccagtgtttggtgttt
ctgggacatcagaccttcgtgtcccagcctggctatgttgggctggagggcttgccttac
ttcctggaggagcccgaagacaggactgtggccgccaacacccccttcaacctgagctgc
caagctcagggacccccagagcccgtggacctactctggctccaggatgctgtccccctg
gccacggctccaggtcacggcccccagcgcagcctgcatgttccagggctgaacaagaca
tcctctttctcctgcgaagcccataacgccaagggggtcaccacatcccgcacagccacc
atcacagtgctcccccagcagccccgtaacctccacctggtctcccgccaacccacggag
ctggaggtggcttggactccaggcctgagcggcatctaccccctgacccactgcaccctg
caggctgtgctgtcagacgatgggatgggcatccaggcgggagaaccagaccccccagag
gagcccctcacctcgcaagcatccgtgcccccccatcagcttcggctaggcagcctccat
cctcacaccccttatcacatccgcgtggcatgcaccagcagccagggcccctcatcctgg
acccactggcttcctgtggagacgccggagggagtgcccctgggcccccctgagaacatt
agtgctacgcggaatgggagccaggccttcgtgcattggcaagagccccgggcgcccctg
cagggtaccctgttagggtaccggctggcgtatcaaggccaggacaccccagaggtgcta
atggacatagggctaaggcaagaggtgaccctggagctgcagggggacgggtctgtgtcc
aatctgacagtgtgtgtggcagcctacactgctgctggggatggaccctggagcctccca
gtacccctggaggcctggcgcccagggcaagcacagccagtccaccagctggtgaaggaa
ccttcaactcctgccttctcgtggccctggtggtatgtactgctaggagcagtcgtggcc
gctgcctgtgtcctcatcttggctctcttccttgtccaccggcgaaagaaggagacccgt
tatggagaagtgtttgaaccaacagtggaaagaggtgaactggtagtcaggtaccgcgtg
cgcaagtcctacagtcgtcggaccactgaagctaccttgaacagcctgggcatcagtgaa
gagctgaaggagaagctgcgggatgtgatggtggaccggcacaaggtggccctggggaag
actctgggagagggagagtttggagctgtgatggaaggccagctcaaccaggacgactcc
atcctcaaggtggctgtgaagacgatgaagattgccatctgcacgaggtcagagctggag
gatttcctgagtgaagcggtctgcatgaaggaatttgaccatcccaacgtcatgaggctc
atcggtgtctgtttccagggttctgaacgagagagcttcccagcacctgtggtcatctta
cctttcatgaaacatggagacctacacagcttcctcctctattcccggctcggggaccag
ccagtgtacctgcccactcagatgctagtgaagttcatggcagacatcgccagtggcatg
gagtatctgagtaccaagagattcatacaccgggacctggcggccaggaactgcatgctg
aatgagaacatgtccgtgtgtgtggcggacttcgggctctccaagaagatctacaatggg
gactactaccgccagggacgtatcgccaagatgccagtcaagtggattgccattgagagt
ctagctgaccgtgtctacaccagcaagagcgatgtgtggtccttcggggtgacaatgtgg
gagattgccacaagaggccaaaccccatatccgggcgtggagaacagcgagatttatgac
tatctgcgccagggaaatcgcctgaagcagcctgcggactgtctggatggactgtatgcc
ttgatgtcgcggtgctgggagctaaatccccaggaccggccaagttttacagagctgcgg
gaagatttggagaacacactgaaggccttgcctcctgcccaggagcctgacgaaatcctc
tatgtcaacatggatgagggtggaggttatcctgaaccccctggagctgcaggaggagct
gaccccccaacccagccagaccctaaggattcctgtagctgcctcactgcggctgaggtc
catcctgctggacgctatgtcctctgcccttccacaacccctagccccgctcagcctgct
gataggggctccccagcagccccagggcaggaggatggtgcctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   OMIM (2)   
Drug (17)   
   KEGG DRUG (17)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (39)   
   RefSeq(nuc) (3)   
   GenBank (18)   
   EMBL (18)   
3D Structure (4)   
   PDB (4)   
Protein domain (14)   
   Pfam (14)   
All databases (116)   

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