KEGG   Homo sapiens (human): 5788
Entry
5788              CDS       T01001                                 

Gene name
PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Definition
(RefSeq) protein tyrosine phosphatase receptor type C
  KO
K06478  receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa05132  Salmonella infection
hsa05340  Primary immunodeficiency
Disease
H00091  T-B+Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    5788 (PTPRC)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    5788 (PTPRC)
   04666 Fc gamma R-mediated phagocytosis
    5788 (PTPRC)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    5788 (PTPRC)
  09163 Immune disease
   05340 Primary immunodeficiency
    5788 (PTPRC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5788 (PTPRC)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    5788 (PTPRC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     5788 (PTPRC)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Receptor PTPs
    5788 (PTPRC)
CD molecules [BR:hsa04090]
 Proteins
  5788 (PTPRC)
SSDB
Motif
Pfam: Y_phosphatase CD45 PTP_N fn3 Y_phosphatase3 PTPlike_phytase DSPc GnsAB_toxin TM231
Other DBs
NCBI-GeneID: 5788
NCBI-ProteinID: NP_002829
OMIM: 151460
HGNC: 9666
Ensembl: ENSG00000081237
Vega: OTTHUMG00000035702
Pharos: P08575(Tchem)
UniProt: P08575
Structure
PDB: 
5FN7 5FMV 1YGR 1YGU 5FN6

Position
1q31.3-q32.1
AA seq 1306 aa
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPA
STFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSA
GTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAAL
PARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYL
YNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVP
PGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLE
PEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFH
NFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT
KSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFR
VKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYK
IYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSI
PRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPR
KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVV
VKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEA
QYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ
HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA
SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK
QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISM
IQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQV
VKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDAN
CVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
NT seq 3921 nt   +upstreamnt  +downstreamnt
atgaccatgtatttgtggcttaaactcttggcatttggctttgcctttctggacacagaa
gtatttgtgacagggcaaagcccaacaccttcccccactggattgactacagcaaagatg
cccagtgttccactttcaagtgaccccttacctactcacaccactgcattctcacccgca
agcacctttgaaagagaaaatgacttctcagagaccacaacttctcttagtccagacaat
acttccacccaagtatccccggactctttggataatgctagtgcttttaataccacaggt
gtttcatcagtacagacgcctcaccttcccacgcacgcagactcgcagacgccctctgct
ggaactgacacgcagacattcagcggctccgccgccaatgcaaaactcaaccctacccca
ggcagcaatgctatctcagatgtcccaggagagaggagtacagccagcacctttcctaca
gacccagtttccccattgacaaccaccctcagccttgcacaccacagctctgctgcctta
cctgcacgcacctccaacaccaccatcacagcgaacacctcagatgcctaccttaatgcc
tctgaaacaaccactctgagcccttctggaagcgctgtcatttcaaccacaacaatagct
actactccatctaagccaacatgtgatgaaaaatatgcaaacatcactgtggattactta
tataacaaggaaactaaattatttacagcaaagctaaatgttaatgagaatgtggaatgt
ggaaacaatacttgcacaaacaatgaggtgcataaccttacagaatgtaaaaatgcgtct
gtttccatatctcataattcatgtactgctcctgataagacattaatattagatgtgcca
ccaggggttgaaaagtttcagttacatgattgtacacaagttgaaaaagcagatactact
atttgtttaaaatggaaaaatattgaaacctttacttgtgatacacagaatattacctac
agatttcagtgtggtaatatgatatttgataataaagaaattaaattagaaaaccttgaa
cccgaacatgagtataagtgtgactcagaaatactctataataaccacaagtttactaac
gcaagtaaaattattaaaacagattttgggagtccaggagagcctcagattattttttgt
agaagtgaagctgcacatcaaggagtaattacctggaatccccctcaaagatcatttcat
aattttaccctctgttatataaaagagacagaaaaagattgcctcaatctggataaaaac
ctgatcaaatatgatttgcaaaatttaaaaccttatacgaaatatgttttatcattacat
gcctacatcattgcaaaagtgcaacgtaatggaagtgctgcaatgtgtcatttcacaact
aaaagtgctcctccaagccaggtctggaacatgactgtctccatgacatcagataatagt
atgcatgtcaagtgtaggcctcccagggaccgtaatggcccccatgaacgttaccatttg
gaagttgaagctggaaatactctggttagaaatgagtcgcataagaattgcgatttccgt
gtaaaagatcttcaatattcaacagactacacttttaaggcctattttcacaatggagac
tatcctggagaaccctttattttacatcattcaacatcttataattctaaggcactgata
gcatttctggcatttctgattattgtgacatcaatagccctgcttgttgttctctacaaa
atctatgatctacataagaaaagatcctgcaatttagatgaacagcaggagcttgttgaa
agggatgatgaaaaacaactgatgaatgtggagccaatccatgcagatattttgttggaa
acttataagaggaagattgctgatgaaggaagactttttctggctgaatttcagagcatc
ccgcgggtgttcagcaagtttcctataaaggaagctcgaaagccctttaaccagaataaa
aaccgttatgttgacattcttccttatgattataaccgtgttgaactctctgagataaac
ggagatgcagggtcaaactacataaatgccagctatattgatggtttcaaagaacccagg
aaatacattgctgcacaaggtcccagggatgaaactgttgatgatttctggaggatgatt
tgggaacagaaagccacagttattgtcatggtcactcgatgtgaagaaggaaacaggaac
aagtgtgcagaatactggccgtcaatggaagagggcactcgggcttttggagatgttgtt
gtaaagatcaaccagcacaaaagatgtccagattacatcattcagaaattgaacattgta
aataaaaaagaaaaagcaactggaagagaggtgactcacattcagttcaccagctggcca
gaccacggggtgcctgaggatcctcacttgctcctcaaactgagaaggagagtgaatgcc
ttcagcaatttcttcagtggtcccattgtggtgcactgcagtgctggtgttgggcgcaca
ggaacctatatcggaattgatgccatgctagaaggcctggaagccgagaacaaagtggat
gtttatggttatgttgtcaagctaaggcgacagagatgcctgatggttcaagtagaggcc
cagtacatcttgatccatcaggctttggtggaatacaatcagtttggagaaacagaagtg
aatttgtctgaattacatccatatctacataacatgaagaaaagggatccacccagtgag
ccgtctccactagaggctgaattccagagacttccttcatataggagctggaggacacag
cacattggaaatcaagaagaaaataaaagtaaaaacaggaattctaatgtcatcccatat
gactataacagagtgccacttaaacatgagctggaaatgagtaaagagagtgagcatgat
tcagatgaatcctctgatgatgacagtgattcagaggaaccaagcaaatacatcaatgca
tcttttataatgagctactggaaacctgaagtgatgattgctgctcagggaccactgaag
gagaccattggtgacttttggcagatgatcttccaaagaaaagtcaaagttattgttatg
ctgacagaactgaaacatggagaccaggaaatctgtgctcagtactggggagaaggaaag
caaacatatggagatattgaagttgacctgaaagacacagacaaatcttcaacttatacc
cttcgtgtctttgaactgagacattccaagaggaaagactctcgaactgtgtaccagtac
caatatacaaactggagtgtggagcagcttcctgcagaacccaaggaattaatctctatg
attcaggtcgtcaaacaaaaacttccccagaagaattcctctgaagggaacaagcatcac
aagagtacacctctactcattcactgcagggatggatctcagcaaacgggaatattttgt
gctttgttaaatctcttagaaagtgcggaaacagaagaggtagtggatatttttcaagtg
gtaaaagctctacgcaaagctaggccaggcatggtttccacattcgagcaatatcaattc
ctatatgacgtcattgccagcacctaccctgctcagaatggacaagtaaagaaaaacaac
catcaagaagataaaattgaatttgataatgaagtggacaaagtaaagcaggatgctaat
tgtgttaatccacttggtgccccagaaaagctccctgaagcaaaggaacaggctgaaggt
tctgaacccacgagtggcactgaggggccagaacattctgtcaatggtcctgcaagtcca
gctttaaatcaaggttcatag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (47)   
   KEGG ORTHOLOGY (1)   
   RefGene (33)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (60)   
   RefSeq(nuc) (8)   
   GenBank (26)   
   EMBL (26)   
Protein domain (9)   
   Pfam (9)   
All databases (139)   

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