KEGG   Homo sapiens (human): 6041
Entry
6041              CDS       T01001                                 

Gene name
RNASEL, PRCA1, RNS4
Definition
(RefSeq) ribonuclease L
  KO
K01165  ribonuclease L
Organism
hsa  Homo sapiens (human)
Pathway
hsa04621  NOD-like receptor signaling pathway
hsa05160  Hepatitis C
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
Network
nt06137  OAS/RNase L pathway (viruses)
nt06163  Hepatitis C virus (HCV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06263  Hepatocellular carcinoma
  Element
N00515  Oligoadenylate synthetase (OAS)/RNase L pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    6041 (RNASEL)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    6041 (RNASEL)
   05160 Hepatitis C
    6041 (RNASEL)
   05168 Herpes simplex virus 1 infection
    6041 (RNASEL)
SSDB
Motif
Pfam: Ank_2 Ank_4 Ank_5 Ank Ank_3 Ribonuc_2-5A Pkinase PK_Tyr_Ser-Thr Kdo RIO1 Pkinase_fungal Endonuc-EcoRV Choline_kinase
Other DBs
NCBI-GeneID: 6041
NCBI-ProteinID: NP_066956
OMIM: 180435
HGNC: 10050
Ensembl: ENSG00000135828
Vega: OTTHUMG00000035213
Pharos: Q05823(Tchem)
UniProt: Q05823
Structure
PDB: 
1WDY 4OAV 4G8K 4OAU 4G8L

Position
1q25.3
AA seq 741 aa
MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW
TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE
CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH
VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK
TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD
CGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGK
LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF
YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG
YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE
DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG
NESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVG
DLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTH
SPNKPQCDGAGGASGLASPGC
NT seq 2226 nt   +upstreamnt  +downstreamnt
atggagagcagggatcataacaacccccaggagggacccacgtcctccagcggtagaagg
gctgcagtggaagacaatcacttgctgattaaagctgttcaaaacgaagatgttgacctg
gtccagcaattgctggaaggtggagccaatgttaatttccaggaagaggaagggggctgg
acacctctgcataacgcagtacaaatgagcagggaggacattgtggaacttctgcttcgt
catggtgctgaccctgttctgaggaagaagaatggggccacgccttttatcctcgcagcg
attgcggggagcgtgaagctgctgaaacttttcctttctaaaggagcagatgtcaatgag
tgtgatttttatggcttcacagccttcatggaagccgctgtgtatggtaaggtcaaagcc
ctaaaattcctttataagagaggagcaaatgtgaatttgaggcgaaagacaaaggaggat
caagagcggctgaggaaaggaggggccacagctctcatggacgctgctgaaaaaggacac
gtagaggtcttgaagattctccttgatgagatgggggcagatgtaaacgcctgtgacaat
atgggcagaaatgccttgatccatgctctcctgagctctgacgatagtgatgtggaggct
attacgcatctgctgctggaccatggggctgatgtcaatgtgaggggagaaagagggaag
actcccctgatcctggcagtggagaagaagcacttgggtttggtgcagaggcttctggag
caagagcacatagagattaatgacacagacagtgatggcaaaacagcactgctgcttgct
gttgaactcaaactgaagaaaatcgccgagttgctgtgcaaacgtggagccagtacagat
tgtggggatcttgttatgacagcgaggcggaattatgaccattcccttgtgaaggttctt
ctctctcatggagccaaagaagattttcaccctcctgctgaagactggaagcctcagagc
tcacactggggggcagccctgaaggatctccacagaatataccgccctatgattggcaaa
ctcaagttctttattgatgaaaaatacaaaattgctgatacttcagaaggaggcatctac
ctggggttctatgagaagcaagaagtagctgtgaagacgttctgtgagggcagcccacgt
gcacagcgggaagtctcttgtctgcaaagcagccgagagaacagtcacttggtgacattc
tatgggagtgagagccacaggggccacttgtttgtgtgtgtcaccctctgtgagcagact
ctggaagcgtgtttggatgtgcacagaggggaagatgtggaaaatgaggaagatgaattt
gcccgaaatgtcctgtcatctatatttaaggctgttcaagaactacacttgtcctgtgga
tacacccaccaggatctgcaaccacaaaacatcttaatagattctaagaaagctgctcac
ctggcagattttgataagagcatcaagtgggctggagatccacaggaagtcaagagagat
ctagaggaccttggacggctggtcctctatgtggtaaagaagggaagcatctcatttgag
gatctgaaagctcaaagtaatgaagaggtggttcaactttctccagatgaggaaactaag
gacctcattcatcgtctcttccatcctggggaacatgtgagggactgtctgagtgacctg
ctgggtcatcccttcttttggacttgggagagccgctataggacgcttcggaatgtggga
aatgaatccgacatcaaaacacgaaaatctgaaagtgagatcctcagactactgcaacct
gggccttctgaacattccaaaagttttgacaagtggacgactaagattaatgaatgtgtt
atgaaaaaaatgaataagttttatgaaaaaagaggcaatttctaccagaacactgtgggt
gatctgctaaagttcatccggaatttgggagaacacattgatgaagaaaagcataaaaag
atgaaattaaaaattggagacccttccctgtattttcagaagacatttccagatctggtg
atctatgtctacacaaaactacagaacacagaatatagaaagcatttcccccaaacccac
agtccaaacaagcctcagtgtgatggagctggtggggccagtgggttggccagccctggg
tgctga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (1)   
   KEGG NETWORK (1)   
Disease (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (29)   
   RefSeq(nuc) (3)   
   GenBank (13)   
   EMBL (13)   
Protein domain (13)   
   Pfam (13)   
All databases (81)   

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